Neal Russell, Anna C. Seale, Megan O’Driscoll, Catherine O’Sullivan et al.
BACKGROUND: Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This artic, the third of 11, estimates the incidence of maternal GBS disease worldwide. METHODS: We conducted systematic literature reviews (PubMed/Medline,...
Anna C. Seale, Fiorella Bianchi-Jassir, Neal Russell, Maya Kohli-Lynch et al.
BACKGROUND: We aimed to provide the first comprehensive estimates of the burden of group B Streptococcus (GBS), including invasive disease in pregnant and postpartum women, fetal infection/stillbirth, and infants. Intrapartum antibiotic prophylaxis is the current mainstay of prevention, reducing ear...
Lola Madrid, Anna C. Seale, Maya Kohli-Lynch, Karen Edmond et al.
BACKGROUND: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasiv...
Fiorella Bianchi-Jassir, Anna C. Seale, Maya Kohli-Lynch, Joy E Lawn et al.
BACKGROUND: Preterm birth complications are the leading cause of deaths among children <5 years of age. Studies have suggested that group B Streptococcus (GBS) maternal rectovaginal colonization during pregnancy may be a risk factor for preterm delivery. This article is the fifth of 11 in a series. ...
Maya Kohli-Lynch, Neal Russell, Anna C. Seale, Ziyaad Dangor et al.
BACKGROUND: Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopmental impairment (NDI), a burden not previously systematically quantified. This is the 10th of 11 articles estimating the burden of GBS disease. Here we aimed to estimate NDI in survivors of infant GBS di...
Kirsty Le Doaré, Megan O’Driscoll, Kim Turner, Farah Seedat et al.
BACKGROUND: Intrapartum antibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease. However, there is no description of how IAP is used around the world. This article is the sixth in a series estimating the burden of GBS disease. Here we aimed to review GBS scree...
Neal Russell, Anna C. Seale, Catherine O’Sullivan, Kirsty Le Doaré et al.
BACKGROUND: Early-onset group B streptococcal disease (EOGBS) occurs in neonates (days 0-6) born to pregnant women who are rectovaginally colonized with group B Streptococcus (GBS), but the risk of EOGBS from vertical transmission has not been systematically reviewed. This article, the seventh in a ...
Anna C. Seale, Hannah Blencowe, Fiorella Bianchi-Jassir, Nicholas D. Embleton et al.
BACKGROUND: There are an estimated 2.6 million stillbirths each year, many of which are due to infections, especially in low- and middle-income contexts. This paper, the eighth in a series on the burden of group B streptococcal (GBS) disease, aims to estimate the percentage of stillbirths associated...
Jennifer Hall, Nadine Hack Adams, Linda Bartlett, Anna C. Seale et al.
Background. Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide.
Joy E Lawn, Fiorella Bianchi-Jassir, Neal Russell, Maya Kohli-Lynch et al.
Improving maternal, newborn, and child health is central to Sustainable Development Goal targets for 2030, requiring acceleration especially to prevent 5.6 million deaths around the time of birth. Infections contribute to this burden, but etiological data are limited. Group B Streptococcus (GBS) is ...
Clara Calvert, Meredith Brockway, Helga Zoëga, Jessica E. Miller et al.
Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from -90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this variation reflects real differences in lockdown impac...
Johan Vekemans, Vasee Moorthy, Martin Friede, Mark R. Alderson et al.
Group B streptococcus, found in the vagina or lower gastrointestinal tract of about 10-40% of women of reproductive age, is a leading cause of early life invasive bacterial disease, potentially amenable to prevention through maternal immunization during pregnancy. Following a consultation process wi...
Cally J Tann, Kathryn A. Martinello, Samantha Sadoo, Joy E Lawn et al.
BACKGROUND: Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairment. Infection can sensitize the newborn brain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed. This paper is the ninth in an 11-article series estimating t...
Johan Vekemans, Jonathan Crofts, Carol J. Baker, David Goldblatt et al.
The development of a group B Streptococcus (GBS) vaccine for maternal immunization constitutes a global public health priority, to prevent GBS-associated early life invasive disease, stillbirth, premature birth, maternal sepsis, adverse neurodevelopmental consequences, and to reduce perinatal antibi...
Anna C. Seale, Michael Head, Elizabeth Fitchett, Stefania Vergnano et al.
Further progress in decreasing child mortality depends on reducing the 2·9 million neonatal deaths each year, around a quarter of which are directly due to infection.1Lawn JE Blencowe H Oza S et al.Every Newborn: progress, priorities, and potential beyond survival.Lancet. 2014; 384: 189-205Summary F...