Dianna M. Blau, J Patrick Caneer, Rebecca Philipsborn, Shabir A. Madhi et al.
Mortality surveillance and cause of death data are instrumental in improving health, identifying diseases and conditions that cause a high burden of preventable deaths, and allocating resources to prevent these deaths. The Child Health and Mortality Prevention Surveillance (CHAMPS) network uses a st...
Zachary J. Madewell, Cynthia G. Whitney, Sithembiso Velaphi, Portia Mutevedzi et al.
Importance: Although child mortality trends have decreased worldwide, deaths among children younger than 5 years of age remain high and disproportionately circumscribed to sub-Saharan Africa and Southern Asia. Tailored and innovative approaches are needed to increase access, coverage, and quality of...
Sana Mahtab, Shabir A. Madhi, Vicky L. Baillie, Toyah Els et al.
Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 a...
Dianna M. Blau, Vicky L. Baillie, Toyah Els, Sana Mahtab et al.
BACKGROUND: Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in ch...
Sana Mahtab, Dianna M. Blau, Zachary J. Madewell, Ikechukwu U. Ogbuanu et al.
BACKGROUND: The Child Health and Mortality Prevention Surveillance (CHAMPS) Network programme undertakes post-mortem minimally invasive tissue sampling (MITS), together with collection of ante-mortem clinical information, to investigate causes of childhood deaths across multiple countries. We aimed ...
Elisa Garcia Gomez, Kitiezo Aggrey Igunza, Zachary J. Madewell, Victor Akelo et al.
Delays in illness recognition, healthcare seeking, and in the provision of appropriate clinical care are common in resource-limited settings. Our objective was to determine the frequency of delays in the "Three Delays-in-Healthcare", and factors associated with delays, among deceased infants and chi...
Sana Mahtab, Zachary J. Madewell, Shabir A. Madhi, Amy Wise et al.
Abstract Background Invasive Group B Streptococcus (GBS) is a common cause of early-onset neonatal sepsis and is also associated with stillbirth. This study aimed to determine the proportion of stillborn infants and infants who died between 0 and 90 days attributable to GBS using postmortem minimall...
Chris A. Rees, Kitiezo Aggrey Igunza, Zachary J. Madewell, Victor Akelo et al.
Background: Most childhood deaths globally are considered preventable through high-quality clinical care, which includes adherence to clinical care recommendations. Our objective was to describe adherence to World Health Organization recommendations for the management of leading causes of death amon...
Sana Mahtab, Zachary J. Madewell, Vicky L. Baillie, Ziyaad Dangor et al.
BACKGROUND: The role of meningitis in causing deaths and in children under 5 is unclear, especially since widespread use of vaccines to prevent common causes of meningitis. Child Health and Mortality Prevention Surveillance (CHAMPS) uses post-mortem minimally invasive tissue sampling (MITS) and ante...
Sara Ajanovic, Zachary J. Madewell, Shams El Arifeen, Emily S. Gurley et al.
Importance: The emergence of acute neurological symptoms in children necessitates immediate intervention. Although low- and middle-income countries (LMICs) bear the highest burden of neurological diseases, there is a scarcity of diagnostic and therapeutic resources. Therefore, current understanding ...
Haleluya Leulseged, Christine Bethencourt, Kitiezo Aggrey Igunza, Victor Akelo et al.
INTRODUCTION: Determining aetiology of severe illness can be difficult, especially in settings with limited diagnostic resources, yet critical for providing life-saving care. Our objective was to describe the accuracy of antemortem clinical diagnoses in young children in high-mortality settings, com...
Afruna Rahman, Meghna Ray, Zachary J. Madewell, Kitiezo Aggrey Igunza et al.
Importance: Most of the 2.3 million annual neonatal deaths occur in sub-Saharan Africa and South Asia, with perinatal asphyxia and neonatal sepsis being the leading causes of neonatal mortality. Most neonatal deaths are considered preventable through high-quality clinical care, which includes adhere...
Elizabeth Quincer, Rebecca Philipsborn, Diane Morof, Navit T. Salzberg et al.
INTRODUCTION: The high burden of stillbirths and neonatal deaths is driving global initiatives to improve birth outcomes. Discerning stillbirths from neonatal deaths can be difficult in some settings, yet this distinction is critical for understanding causes of perinatal deaths and improving resusci...
Inácio Mandomando, Zachary J. Madewell, Portia C Mutevedzi, Kitiezo Aggrey Igunza et al.
BACKGROUND Despite widespread implementation of vertical transmission prevention and paediatric HIV programmes, HIV remains a leading cause of child mortality. We analysed HIV-attributed deaths in the Child Health and Mortality Prevention Surveillance (CHAMPS) network, focusing on comorbidities, co-...
Kitiezo Aggrey Igunza, Namrata Ramakrishna, Zachary J. Madewell, Victor Akelo et al.
Abstract An estimated 1.9 million stillbirths and 2.3 million neonatal deaths occurred globally in 2023, disproportionately clustered in sub-Saharan Africa and South Asia. We aimed to determine the frequency of delays in illness recognition, healthcare seeking, and healthcare receipt among cases of ...
Rosauro Varo, Kaitlin Cole, Zachary J. Madewell, Jaime Fanjul Iglesias et al.
OBJECTIVES: To describe (1) the proportion of deaths that were in recently hospitalised children and (2) causes of mortality among deceased children aged 0-59 months with preceding hospitalisations who enrolled in a mortality surveillance programme. DESIGN: Descriptive study using prospectively coll...
Kephas Otieno, Lorraine Vitek, Zachary J. Madewell, Kitiezo Aggrey Igunza et al.
Abstract Background: In sub-Saharan Africa as much as 60% of children with sickle cell disease (SCD) die before the age of five. Despite high mortality rates among children with SCD in sub-Saharan Africa, there is little understanding of specific causes of death in these children. Prior studies asse...
Afruna Rahman, Kyu Han Lee, Shams El Arifeen, Mohammad Zahid Hossain et al.
Sara Ajanovic, Zachary J. Madewell, Shams El Arifeen, Emily S. Gurley et al.