Monika Karmin, Lauri Saag, Mário Vicente, Melissa A. Wilson Sayres et al.
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ...
Luca Pagani, Daniel J. Lawson, Evelyn Jagoda, Alexander Mörseburg et al.
High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for infe...
Simon J. Anthony, Jonathan H. Epstein, Kris A. Murray, Isamara Navarrete‐Macias et al.
UNLABELLED: The majority of emerging zoonoses originate in wildlife, and many are caused by viruses. However, there are no rigorous estimates of total viral diversity (here termed "virodiversity") for any wildlife species, despite the utility of this to future surveillance and control of emerging zo...
Dieter B. Wildenauer, Sibylle G. Schwab, Margot Albus, Joachim Hallmayer et al.
In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403-567 informative pedigrees per marker, and in the Original sample which produced each finding (the Johns Hop...
Maziar Moradi‐Lakeh, Mohammad H. Forouzanfar, Stein Emil Vollset, Charbel El Bcheraoui et al.
Objectives We used findings from the Global Burden of Disease Study 2013 to report the burden of musculoskeletal disorders in the Eastern Mediterranean Region (EMR). Methods The burden of musculoskeletal disorders was calculated for the EMR's 22 countries between 1990 and 2013. A systematic analysis...
Marina Romanello, Maria Walawender, Shih-Che Hsu, Annalyse Moskeland et al.
Claire Palles, Laura Chegwidden, Xinzhong Li, John M. Findlay et al.
BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subse...
Ignacio Blanco, Karoline Kuchenbaecker, Daniel Cuadras, Xianshu Wang et al.
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the...
Maria A. Martin, Emmanuel Amoah Boakye, Emily Boyd, Wendy Broadgate et al.
Non-technical summary We summarize what we assess as the past year's most important findings within climate change research: limits to adaptation, vulnerability hotspots, new threats coming from the climate–health nexus, climate (im)mobility and security, sustainable practices for land use and finan...
Nigel Haggan, Claire Brignall, Louisa J. Wood
This Report documents the presentations given at the World’s first international conference on the management value of the resource knowledge of small scale, indigenous and commercial fishers. The conference was inspired by Dr Robert (Bob) Johannes, whose 1981 Book ‘Words of the Lagoon’, was the fir...
Nicole Fusco, Bradley J. Cosentino, James P. Gibbs, Maximilian L. Allen et al.
Urbanization is a persistent and widespread driver of global environmental change, potentially shaping evolutionary processes due to genetic drift and reduced gene flow in cities induced by habitat fragmentation and small population sizes. We tested this prediction for the eastern grey squirrel (Sci...
Ali Asm, Ashraf, Gaze, Reinhard Doerries et al.
How has the study of intelligence evolved in the global North and why has it stagnated in the global South? This paper offers a South Asian perspective by employing a mixed method strategy. It argues that the academic and professional communities in the global North have contributed to the developme...
Sumana Banerjee, Jean‐Nicolas Beisel, Francisco Bellido-Leiva, Dianne Bentley et al.
GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study, Vinay Nangia, Prof Jost B Jonas et al.
PURPOSE: To estimate the prevalence of vision loss for 2020 in South and Central Asia and analyze trends since 1990. METHODS: In a systematic literature review, we estimated the prevalence of blindness, visual impairment (VI) and presbyopia-related VI in 1990,2000,2010, and 2020. RESULTS: The study ...
Ryan T. Muir, Arunima Kapoor, Megan L. Cayley, Michelle N. Sicard et al.