Denise O. Garrett, Ashley T Longley, Kristen Aiemjoy, Mohammad Tahir Yousafzai et al.
BACKGROUND: Precise enteric fever disease burden data are needed to inform prevention and control measures, including the use of newly available typhoid vaccines. We established the Surveillance for Enteric Fever in Asia Project (SEAP) to inform these strategies. METHODS: From September, 2016, to Se...
Kristen Aiemjoy, Jessica C. Seidman, Senjuti Saha, Sira Jam Munira et al.
BACKGROUND: The incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae (Salmonella enterica serovars Typhi and Paratyphi), is largely unknown in regions without blood culture surveillance. The aim of this study was to evaluate whether new diagnostic serological m...
Megan E. Carey, William R MacWright, Justin Im, James Meiring et al.
Building on previous multicountry surveillance studies of typhoid and others salmonelloses such as the Diseases of the Most Impoverished program and the Typhoid Surveillance in Africa Project, several ongoing blood culture surveillance studies are generating important data about incidence, severity,...
Jason R. Andrews, Alexander T. Yu, Senjuti Saha, Jivan Shakya et al.
Abstract Enteric fever remains a major cause of morbidity in developing countries with poor sanitation conditions that enable fecal contamination of water distribution systems. Historical evidence has shown that contamination of water systems used for household consumption or agriculture are key tra...
Jason R. Andrews, Krista Vaidya, Shampa Saha, Mohammad Tahir Yousafzai et al.
BACKGROUND: Characterizing healthcare-seeking patterns for acute febrile illness is critical for generating population-based enteric fever incidence estimates from facility-based surveillance data. METHODS: We used a hybrid model in the Surveillance for Enteric Fever in Asia Project (SEAP) to assess...
Kristen Aiemjoy, Dipesh Tamrakar, Shampa Saha, Shiva Ram Naga et al.
BACKGROUND: Enteric fever, a bacterial infection caused by Salmonella enterica serotypes Typhi and Paratyphi A, frequently presents as a nonlocalizing febrile illness that is difficult to distinguish from other infectious causes of fever. Blood culture is not widely available in endemic settings and...
Dipesh Tamrakar, Krista Vaidya, Alexander T. Yu, Kristen Aiemjoy et al.
BACKGROUND: Typhoid fever is endemic in the urban Kathmandu Valley of Nepal; however, there have been no population-based studies of typhoid outside of this community in the past 3 decades. Whether typhoid immunization should be prioritized in periurban and rural communities has been unclear. METHOD...
Sneha Shrestha, Késia Esther da Silva, Jivan Shakya, Alexander T. Yu et al.
BACKGROUND: Environmental surveillance, using detection of Salmonella Typhi DNA, has emerged as a potentially useful tool to identify typhoid-endemic settings; however, it is relatively costly and requires molecular diagnostic capacity. We sought to determine whether S. Typhi bacteriophages are abun...
Krista Vaidya, Kristen Aiemjoy, Farah Naz Qamar, Samir K. Saha et al.
BACKGROUND: Antibiotic use prior to seeking care at a hospital may reduce the sensitivity of blood culture for enteric fever, with implications for both clinical care and surveillance. The Surveillance for Enteric Fever in Asia Project (SEAP) is a prospective study of enteric fever incidence in Nepa...
Denise O Garrett, Ashley T Longley, Kristen Aiemjoy, Farah Naz Qamar et al.
Background: Precise enteric fever disease burden data are needed to inform prevention and control measures, including the use of newly available typhoid vaccines. To inform these strategies, the Surveillance for Enteric Fever in Asia Project (SEAP) conducted prospective, facility-based surveillance ...
Kristen Aiemjoy, Jessica C. Seidman, Senjuti Saha, Sira Jam Munira et al.
Abstract Background The incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae , is largely unknown in regions lacking blood culture surveillance. New serologic markers have proven accurate in diagnosing enteric fever, but whether they could be used to reliably e...
Peter Teunis, Jessica C. Seidman, Dipesh Tamrakar, Farah Naz Qamar et al.
Enteric fever, a systematic bacterial infection caused by Salmonella Typhi and Paratyphi, continues to impose a significant public health burden in low and middle-income countries, yet our understanding of the serum antibody dynamics following infection remains incomplete. Although previous work has...
Jessica C. Seidman, Kristen Aiemjoy, Mehreen Adnan, Irum Fatima Dehraj et al.
Existing methods to identify patients infected with Salmonella enterica Typhi (S. Typhi) or Paratyphi are inadequately accurate, affordable, and efficient. We evaluated the discriminatory power of antibodies to S. Typhi hemolysin E (HlyE) and lipopolysaccharide (LPS) in Bangladesh, Nepal, and Pakist...
Kristina Lai, Chris Orwa, Jessica C. Seidman, Denise O. Garrett et al.
Motivation: Seroincidence-the rate of new infections in a population-is a key measure for understanding pathogen transmission dynamics and informing public health action. Estimating seroincidence from cross-sectional data is complicated by antibody waning, cross-reactivity, and individual heterogene...
Sneha Shrestha, Késia Esther da Silva, Jivan Shakya, Alexander T. Yu et al.
Abstract Environmental surveillance, using detection of Salmonella Typhi DNA, has emerged as a potentially useful tool to identify typhoid-endemic settings; however, it is relatively costly and requires molecular diagnostic capacity. We sought to determine whether S . Typhi bacteriophages are abunda...