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Results for “"LifeLines Cohort Study"”

3 results

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

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Norihiro Kato, CARDIo GRAMplusCD, LifeLines Cohort Study, Marie Loh et al.

Journal: Nature GeneticsYear: 2015Citations: 375

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). ...

Life SciencesBiochemistry, Genetics and Molecular BiologyGeneticsOpen Access
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Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data

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Carol Barahona Ponce, Dominique Scherer, Felix Boekstegers, Valentina Gárate‐Calderón et al.

Journal: International Journal of CancerYear: 2019Citations: 17

Dear editor, An inverse association between arsenic in serum and the risk of gallbladder cancer (GBC) was recently reported in a cross-sectional study conducted by Lee et al. in Shanghai, China.1 This result was surprising, because arsenic has been classified as a human carcinogen and arsenic-contam...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Genome-wide analyses of quantitative generalised anxiety symptom severity

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Megan Skelton, Brittany L. Mitchell, Elham Assary, Danyang Li et al.

Journal: medRxivYear: 2025Citations: 1

We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of which were novel for anxiety. SNP-based heritability was 5.9% ...

Social SciencesPsychologyClinical PsychologyOpen Access
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