Julia Webster, Evropi Τheodoratou, Harish Nair, Ang Choon Seong et al.
BACKGROUND: Pneumonia is the leading cause of child mortality worldwide. Streptococcus pneumoniae (SP) or pneumococcus is estimated to cause 821,000 child deaths each year. It has over 90 serotypes, of which 7 to 13 serotypes are included in current formulations of pneumococcal conjugate vaccines th...
Harish Nair, Vasundhara Verma, Evropi Τheodoratou, Lina Zgaga et al.
BACKGROUND: Respiratory Syncytial Virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in children. It is estimated to cause approximately 33.8 million new episodes of ALRI in children annually, 96% of these occurring in developing countries. It is also estimated to result i...
Daisy Higginson, Evropi Τheodoratou, Harish Nair, Tanvir Huda et al.
BACKGROUND: Measles was responsible for an estimated 100,000 deaths worldwide in 2008. Despite being a vaccine-preventable disease, measles remains a major cause of morbidity and mortality in young children. Although a safe and effective injectable measles vaccine has been available for over 50 year...
Harish Nair, Eva Yi Hung Lau, William Brooks, Ang Choon Seong et al.
BACKGROUND: Influenza is an under-appreciated cause of acute lower respiratory infections (ALRI) in children. It is estimated to cause approximately 20 million new episodes of ALRI in children annually, 97% of these occurring in developing countries. It is also estimated to result in 28000 to 112000...
Alastair G Catto, Lina Zgaga, Evropi Τheodoratou, Tanvir Huda et al.
BACKGROUND: Oxygen therapy is recommended for all of the 1.5 - 2.7 million young children who consult health services with hypoxemic pneumonia each year, and the many more with other serious conditions. However, oxygen supplies are intermittent throughout the developing world. Although oxygen is wel...
Lina Zgaga, Fiona O’Sullivan, Marie M. Cantwell, Liam Murray et al.
Vitamin D has been associated with reduced risk of many cancers, but evidence for esophageal cancer is mixed. To clarify the role of vitamin D, we performed a systematic review and meta-analysis to evaluate the association of vitamin D exposures and esophageal neoplasia, including adenocarcinoma, sq...
Debajeet Choudhuri, Tanvir Huda, Evropi Τheodoratou, Harish Nair et al.
BACKGROUND: Meningococcal meningitis is a major cause of disease worldwide, with frequent epidemics particularly affecting an area of sub-Saharan Africa known as the "meningitis belt". Neisseria meningitidis group A (MenA) is responsible for major epidemics in Africa. Recently W-135 has emerged as a...
Tanvir Huda, Harish Nair, Evropi Τheodoratou, Lina Zgaga et al.
BACKGROUND: Staphylococcus aureus is a commensal of human skin and nares. It is also one of the leading nosocomial pathogens in both developed and developing countries and is responsible for a wide range of life threatening infections, especially in patients who are immunocompromised, post-surgery, ...
Igor Rudan, Evropi Τheodoratou, Lina Zgaga, Harish Nair et al.
A cute lower respiratory infections, which broadly include pneumonia and bronchiolitis, are still the leading cause of childhood mortality.ALRI contributed to 18% of all deaths in children younger than five years of age in 2008 [1], and the main pathogens responsible for high mortality were Streptoc...