Stephanie W. Lo, Kate C. Mellor, Robert Cohen, Alba Redin Alonso et al.
BACKGROUND: Serotype 24F is one of the emerging pneumococcal serotypes after the introduction of pneumococcal conjugate vaccine (PCV). We aimed to identify lineages driving the increase of serotype 24F in France and place these findings into a global context. METHODS: Whole-genome sequencing was per...
Tomoka Nakamura, Adam L. Cohen, Stephanie Schwartz, Jason M. Mwenda et al.
BACKGROUND: The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use. The network was established to strengthen surveillance and laboratory confirmation of meningitis cau...
Joshua C D'Aeth, Mark PG van der Linden, Lesley McGee, Hermı́nia de Lencastre et al.
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A si...
Sophie Belman, Noémie Lefrancq, Susan Nzenze, Sarah Downs et al.
. The extent and mechanisms of spread and vaccine-driven changes in fitness and antimicrobial resistance remain largely unquantified. Here using geolocated genome sequences from South Africa (n = 6,910, collected from 2000 to 2014), we developed models to reconstruct spread, pairing detailed human m...
Stephanie W. Lo, Rebecca A. Gladstone, Andries J. van Tonder, Mignon du Plessis et al.
OBJECTIVES: We reported tet(S/M) in Streptococcus pneumoniae and investigated its temporal spread in relation to nationwide clinical interventions. METHODS: We whole-genome sequenced 12 254 pneumococcal isolates from 29 countries on an Illumina HiSeq sequencer. Serotype, multilocus ST and antibiotic...
Kedibone Ndlangisa, Mignon du Plessis, Stephanie W. Lo, Linda de Gouveia et al.
Pneumococcal serotype 35B is an important non-conjugate vaccine (non-PCV) serotype. Its continued emergence, post-PCV7 in the USA, was associated with expansion of a pre-existing 35B clone (clonal complex [CC] 558) along with post-PCV13 emergence of a non-35B clone previously associated with PCV ser...
Anne von Gottberg, Jackie Kleynhans, Linda de Gouveia, Stefano Tempia et al.
Background: We evaluated the ongoing effects (direct and indirect) of prevention of 13-valent pneumococcal conjugate vaccine (PCV13) serotypes, replacement disease, and effects on antimicrobial resistance, eight years after the introduction of PCV13 in 2011 and before the COVID-19 pandemic. Methods:...
Joshua C D'Aeth, Mark PG van der Linden, Lesley McGee, Hermı́nia de Lencastre et al.
Selection by national-level antibiotic consumption and vaccination trends drives atypical recombinations, frequently resulting in interspecies sequence exchange at many sites across a bacterial species’ chromosome.