Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang, Matthew C. Hibberd et al.
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutr...
Md. Milon Islam, Md. Rezwanul Haque, Hasib Iqbal, Md. Munirul Hasan et al.
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHOD...
Margaret Kosek, Tahmeed Ahmed, Zulfiqar A Bhutta, Laura E. Caulfield et al.
BACKGROUND: Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populati...
Daniel Roth, Shaun K. Morris, Stanley Zlotkin, Alison D. Gernand et al.
BACKGROUND: It is unclear whether maternal vitamin D supplementation during pregnancy and lactation improves fetal and infant growth in regions where vitamin D deficiency is common. METHODS: We conducted a randomized, double-blind, placebo-controlled trial in Bangladesh to assess the effects of week...
Arjun S. Raman, Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang et al.
Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbi...
Tahmeed Ahmed, Santhia Ireen, A.M. Shamsir Ahmed, Sabuktagin Rahman et al.
Although child and maternal malnutrition has been reduced in Bangladesh, the prevalence of underweight (weight-for-age z-score <-2) among children aged less than five years is still high (41%). Nearly one-third of women are undernourished with body mass index of <18.5 kg/m2. The prevalence of anaemi...
Joanne E Arsenault, Elizabeth Yakes Jimenez, M Munirul Islam, M. Belal Hossain et al.
Documentation of micronutrient intake inadequacies among developing country populations is important for planning interventions to control micronutrient deficiencies. The objective of this study was to quantify micronutrient intakes by young children and their primary female caregivers in rural Bang...
ASG Faruque, AM Shamsir Ahmed, Tahmeed Ahmed, M Munirul Islam et al.
Recent data from the World Health Organization showed that about 60% of all deaths, occurring among children aged less than five years (under-five children) in developing countries, could be attributed to malnutrition. It has been estimated that nearly 50.6 million under-five children are malnourish...
Michael J. Barratt, Sharika Nuzhat, Kazi Ahsan, Steven A. Frese et al.
Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. Bifidobacterium longum subspecies infantis is a prominent early colonizer of the infant gut that consumes human milk oligosaccharides (HMOs). We found that the absolute abundance of Bifidobacterium infanti...
Christine Marie George, Shirajum Monira, David A. Sack, Mahamud‐ur Rashid et al.
The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Interven...
Sabiha Shaik, Amit Ranjan, Sumeet K. Tiwari, Arif Hussain et al.
ABSTRACT Escherichia coli sequence type 131 (ST131), a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC) infections, has been known widely for its contribution to the worldwide dissemination of multidrug resistance. Although other ExPEC-associated and ex...
Baitun Nahar, Muttaquina Hossain, Mustafa Mahfuz, M Munirul Islam et al.
Information on the association between stunting and child development is limited from low-income settings including Bangladesh where 36% of children under- 5 are stunted. This study aimed to explore differences in early childhood development (ECD) between stunted (length-for-age z-score [LAZ] < -2) ...
Crystal L. Patil, Ali Turab, Ramya Ambikapathi, Cebisa Noxolo Nesamvuni et al.
We report the infant feeding experiences in the first month of life for 2,053 infants participating in "Malnutrition and Enteric Infections: Consequences for Child Health and Development" (MAL-ED). Eight sites (in Bangladesh, India, Nepal, Pakistan, Brazil, Peru, South Africa, Tanzania), each follow...
Joanne E Arsenault, Elizabeth Yakes Jimenez, M. Belal Hossain, M. Munirul Islam et al.
Rural Bangladeshi populations have a high risk of zinc deficiency due to their consumption of a predominantly rice-based diet with few animal-source foods. Breeding rice for higher zinc content would offer a sustainable approach to increase the population's zinc intakes. The objectives of the study ...