Elizabeth A. Ashley, Mehul Dhorda, Rick M. Fairhurst, Chanaki Amaratunga et al.
BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and Apri...
Nicholas J. White, Sasithon Pukrittayakamee, Tran Tinh Hien, M. Abul Faiz et al.
Although global morbidity and mortality have decreased substantially, malaria, a parasite infection of red blood cells, still kills roughly 2000 people per day, most of whom are children in Africa. Two factors largely account for these decreases; increased deployment of insecticide-treated bednets a...
Md Mahbub Hossain, Samia Tasnim, Abida Sultana, Farah Faizah et al.
The novel coronavirus disease 2019 (COVID-19) has become a pandemic affecting health and wellbeing globally. In addition to the physical health, economic, and social implications, the psychological impacts of this pandemic are increasingly being reported in the scientific literature. This narrative ...
Olivo Miotto, Roberto Amato, Elizabeth A. Ashley, Bronwyn MacInnis et al.
We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, ...
Jason Corburn, David Vlahov, Blessing Mberu, Lee W. Riley et al.
The informal settlements of the Global South are the least prepared for the pandemic of COVID-19 since basic needs such as water, toilets, sewers, drainage, waste collection, and secure and adequate housing are already in short supply or non-existent. Further, space constraints, violence, and overcr...
Sachel Mok, Elizabeth A. Ashley, Pedro Eduardo Ferreira, Lei Zhu et al.
Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of...
Kyaw Myo Tun, Mallika Imwong, Khin Maung Lwin, Aye Aye Win et al.
BACKGROUND: Emergence of artemisinin resistance in southeast Asia poses a serious threat to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has transformed approaches to the monitoring of artemisinin resistance, allowing introduction of molecular surveillance in remo...
M. Jahangir Hossain, Emily S. Gurley, Joel M. Montgomery, Michael Bell et al.
BACKGROUND: In Bangladesh, 4 outbreaks of Nipah virus infection were identified during the period 2001-2004. METHODS: We characterized the clinical features of Nipah virus-infected individuals affected by these outbreaks. We classified patients as having confirmed cases of Nipah virus infection if t...
Arjen M. Dondorp, Sue J. Lee, M A Faiz, Saroj K. Mishra et al.
BACKGROUND: The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain. METHODS: In a large, multicenter treatment trial conducted in Asia, the presenting manifestations and outcome of severe malaria were analyzed in relation ...
Rob W. van der Pluijm, Rupam Tripura, Richard M. Hoglund, Aung Pyae Phyo et al.
BACKGROUND: Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide eff...
A T M Faiz Ahmed, Md Zahidul Islam, Md Sultan Mahmud, Md Emdad Sarker et al.
L. (hemp) has received a lot of attention because of its multipurpose usability, short production cycle, low capital demand in cultivation, possibility of carbon-negative transformation and easy carbon sequestering material. This paper reviews hemp as a very promising renewable resource including it...
Arjen M. Dondorp, Can İnce, Prakaykaew Charunwatthana, Josh Hanson et al.
BACKGROUND: This study sought to describe and quantify microcirculatory changes in the mucosal surfaces of patients with severe malaria, by direct in vivo observation using orthogonal polarization spectral (OPS) imaging. METHODS: The microcirculation in the rectal mucosa of adult patients with sever...
Jeffrey V. Lazarus, Diana Romero, Christopher J. Kopka, Salim S. Abdool Karim et al.
Abstract Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic 1,2 . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governme...
Kristina E. Rudd, Christopher Seymour, Adam R. Aluisio, Marc E. Augustin et al.
Importance: The quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score has not been well-evaluated in low- and middle-income countries (LMICs). Objective: To assess the association of qSOFA with excess hospital death among patients with suspected infection in LMICs and to compare q...
MF Gomes, MA Faiz, John O. Gyapong, Marian Warsame et al.
Background Most malaria deaths occur in rural areas. Rapid progression from illness to death can be interrupted by prompt, effective medication. Antimalarial treatment cannot rescue terminally ill patients but could be effective if given earlier. If patients who cannot be treated orally are several ...
Muhammad Awais, Najeeb Ullah, Javaid Ahmad, Faizan Sikandar et al.
Nanofluid is considered to be a new generation heat transfer medium which has attracted significant attention from the research community for the past two decades due to its reported high effectiveness in various heat transfer applications. Dispersed solid nanoparticles with enhanced thermal conduct...
Mohammad Main Uddin, Mohamed Cassim Mohamed Zakeel, Junaida Shezmin Zavahir, Faiz Marikar et al.
Aquatic ecosystems are contaminated with heavy metals by natural and anthropogenic sources. Whilst some heavy metals are necessary for plants as micronutrients, others can be toxic to plants and humans even in trace concentrations. Among heavy metals, cadmium (Cd), arsenic (As), chromium (Cr), lead ...
Sumit Kane, Maryse Kok, Hermen Ormel, Lilian Otiso et al.
BACKGROUND: In LMICs, Community Health Workers (CHW) increasingly play health promotion related roles involving 'Empowerment of communities'. To be able to empower the communities they serve, we argue, it is essential that CHWs themselves be, and feel, empowered. We present here a critique of how di...
Ridwanur Rahman, Maryam Faiz, Shahjada Selim, Bayzidur Rahman et al.
BACKGROUND: Snake bite is a neglected public health problem in the world and one of the major causes of mortality and morbidity in many areas, particularly in the rural tropics. It also poses substantial economic burdens on the snake bite victims due to treatment related expenditure and loss of prod...
Aiman Awaiz, Faiz Ur Rahman, M. Belal Hossain, Rossita Mohamad Yunus et al.
Context The utility of laparoscopic repair in the treatment of incisional hernia repair is still contentious. Objectives The aim was to conduct a meta-analysis of RCTs investigating the surgical and postsurgical outcomes of elective incisional hernia by open versus laparoscopic method. Data sources ...