Jelle Matthijnssens, Max Ciarlet, Erica Heiman, Ingrid Arijs et al.
Group A rotavirus classification is currently based on the molecular properties of the two outer layer proteins, VP7 and VP4, and the middle layer protein, VP6. As reassortment of all the 11 rotavirus gene segments plays a key role in generating rotavirus diversity in nature, a classification system...
Roy Burstein, Nathaniel J Henry, Michael L. Collison, Laurie B. Marczak et al.
Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable child deaths by 2030-we need consistently estimated data at the subnational ...
Joris Deelen, Marian Beekman, Hae‐Won Uh, Linda Broer et al.
The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent...
Maeen Md. Khairul Akter, Upama Nasrin Haq, Md. Mazedul Islam, Mohammad Abbas Uddin
The textiles and apparel manufacturing industry in the upstream fashion supply chain generates substantial materials waste that requires urgent efforts to manage effectively, reduce environmental impact, and foster sustainable practices. A huge research scope lies in materials waste management of up...
Intza Garin, Emma L. Edghill, İldem Akerman, Oscar Rubio‐Cabezas et al.
Heterozygous coding mutations in the INS gene that encodes preproinsulin were recently shown to be an important cause of permanent neonatal diabetes. These dominantly acting mutations prevent normal folding of proinsulin, which leads to beta-cell death through endoplasmic reticulum stress and apopto...
V. Spike Peterson
Click to increase image sizeClick to decrease image size Acknowledgments I am grateful to Georgina Waylen for her generosity in sharing prepublication work with me; and to Drucilla Barker, Jen Cohen, Deb Figart, Ellen Mutari, Julie Nelson, Paulette Olsen and Ara Wilson for conference discussions reg...
Hiroto Miwa, Mae F. Go, Nobuhiro Sato
The actual distribution of Helicobacter pylori infection and its related diseases in various Asian countries is controversial. Only limited information is available regarding this issue. We discuss the etiological role of H. pylori in gastric cancer through the Asian experience. Seroprevalence of H....
Jean Bousquet, Antonio Addis, Ian M. Adcock, Ioana Agache et al.
The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will ad...
José S. Câmara, Rosa Perestrelo, Cristina V. Berenguer, Carolina Andrade et al.
Green extraction techniques (GreETs) emerged in the last decade as greener and sustainable alternatives to classical sample preparation procedures aiming to improve the selectivity and sensitivity of analytical methods, simultaneously reducing the deleterious side effects of classical extraction tec...
Leonor Gama-Norton, Eva Ferrando, Cristina Ruiz‐Herguido, Zhenyi Liu et al.
Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the haemogenic endothelium/HSC on Jag1-mediated Notch1 signalling. How Notch1 dis...
Jean Bousquet, Peter W. Hellings, Ioana Agache, Anna Bedbrook et al.
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidel...
John G. Hardy, Eneko Larrañeta, Ryan F. Donnelly, Niamh McGoldrick et al.
We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol d...
the ARIA Study Group, J. Jean Bousquet, the MASK Study Group, Holger J. Schünemann et al.
BACKGROUND: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizati...
Local Burden of Disease Vaccine Coverage Collaborators, Alyssa N. Sbarra, Sam Rolfe, Jason Q. Nguyen et al.
Abstract The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs) 1–4 . Globally co...
Megan E. Carey, Zoe A. Dyson, Danielle J. Ingle, Afreenish Amir et al.
Background: serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000). Methods: This is a meta-analysis of global genotype and anti...