Gregory A. Roth, Catherine O. Johnson, Kalkidan Hassen Abate, Foad Abd-Allah et al.
Importance: Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produced previously. Objective: To quantify and des...
Mahfuzar Rahman, Martin Tondel, Sk Akhtar Ahmad, Ireen Akhter Chowdhury et al.
-A prevalence comparison of hypertension among subjects with and those without arsenic exposure through drinking water was conducted in Bangladesh to confirm or refute an earlier observation of a relation in this respect. Wells with and without present arsenic contamination were identified, and we i...
Tahera Akter, Fatema Tuz Jhohura, Fahmida Akter, Tridib Roy Chowdhury et al.
BACKGROUND: Public health is at risk due to chemical contaminants in drinking water which may have immediate health consequences. Drinking water sources are susceptible to pollutants depending on geological conditions and agricultural, industrial, and other man-made activities. Ensuring the safety o...
Anna‐Lena Lindberg, Eva-Charlotte Ekström, Barbro Nermell, Mahfuzar Rahman et al.
Although genetic polymorphisms have been shown to explain some of the large variation observed in the metabolism of inorganic arsenic there may be several other factors playing an important role, e.g. nutrition. The objective of this study was to elucidate the influence of various factors on current...
Barbro Nermell, Anna‐Lena Lindberg, Mahfuzar Rahman, Marika Berglund et al.
This study aims at evaluating the suitability of adjusting urinary concentrations of arsenic, or any other urinary biomarker, for variations in urine dilution by creatinine and specific gravity in a malnourished population. We measured the concentrations of metabolites of inorganic arsenic, creatini...
Brandon L. Pierce, Muhammad G. Kibriya, Tong Lin, Farzana Jasmine et al.
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer. There is inter-individual variation in arsenic metabolism efficiency and susceptibility to arsenic toxicity; however, the basis of this variation ...
Nazmul Sohel, Lars Åke Persson, Mahfuzar Rahman, Peter Kim Streatfield et al.
BACKGROUND: Arsenic is a potent human carcinogen and toxicant. Elevated concentration of arsenic in drinking water is a major public-health problem worldwide. We evaluated risks of adult mortality (due to cancer and cardiovascular and infectious diseases) in relation to arsenic exposure through drin...
Marni Hall, Mary V. Gamble, Vesna Slavkovich, Xinhua Liu et al.
BACKGROUND: In Bangladesh, tens of millions of people have been consuming waterborne arsenic for decades. The extent to which As is transported to the fetus during pregnancy has not been well characterized. OBJECTIVES: We therefore conducted a study of 101 pregnant women who gave birth in Matlab, Ba...
Anna‐Lena Lindberg, Mahfuzar Rahman, Lars Åke Persson, Marie Vahter
It is known that a high fraction of methylarsonate (MA) in urine is a risk modifying factor for several arsenic induced health effects, including skin lesions, and that men are more susceptible for developing skin lesions than women. Thus, we aimed at elucidating the interaction between gender and a...
J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
BACKGROUND: An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown. OBJECTIVE: The objective of this study was to investigate the influence of prenat...
Katherine Moon, Shilpi Oberoi, Aaron Barchowsky, Yu Chen et al.
Background: Consistent evidence at high levels of water arsenic (≥100 µg/l), and growing evidence at low-moderate levels (<100 µg/l), support a link with cardiovascular disease (CVD). The shape of the dose-response across low-moderate and high levels of arsenic in drinking water is uncertain and cri...
Abul Hasnat Milton, Mahfuzar Rahman
Arsenic in drinking water causes a widespread concern in Bangladesh, where a major proportion of tube wells is contaminated. Arsenic ingestion causes skin lesions, which is considered as definite exposure. A prevalence comparison study of respiratory effects among subjects with and without arsenic e...
Brandon L. Pierce, Tong Lin, Lin Chen, Ronald Rahaman et al.
A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for human disease. Less is known regarding the effects of genetic variation on expression of distant genes (trans-eQT...
Marie E. Vahter, Li Li, Barbro Nermell, Anisur Rahman et al.
This study assessed the exposure of pregnant women to arsenic in Matlab, Bangladesh, an area with highly-elevated concentrations of arsenic in tubewells, by measuring concentrations of arsenic in urine. In a defined administrative area, all new pregnancies were identified by urine test in gestationa...
Abul Hasnat Milton, Ziaul Hasan, S. M. Shahidullah, Sinthia Sharmin et al.
The role of nutritional factors in arsenic metabolism and toxicity is not clear. Provision of certain low protein diets resulted in decreased excretion of DMA and increased tissue retention of arsenic in experimental studies. This paper reports a prevalence comparison study conducted in Bangladesh t...