Rapeephan R. Maude, Md. Amir Hossain, Mahtab Uddin Hassan, Sophie Osbourne et al.
INTRODUCTION: Measurement of optic nerve sheath diameter (ONSD) by ultrasound is increasingly used as a marker to detect raised intracranial pressure (ICP). ONSD varies with age and there is no clear consensus between studies for an upper limit of normal. Knowledge of normal ONSD in a healthy popula...
Josh Hanson, Sue J. Lee, Md Amir Hossain, Nicholas M. Anstey et al.
BACKGROUND: Microvascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease's pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe falcip...
Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy et al.
persists in the circulation of artesunate-treated malaria patients in Bangladesh and in French travelers who became infected with malaria in Africa. HRP2 persisted in whole blood (not plasma) of artesunate-treated patients with malaria at higher levels compared to quinine-treated patients. Using an ...
Katherine Plewes, Hugh W. F. Kingston, Aniruddha Ghose, Thanaporn Wattanakul et al.
Background: Acute kidney injury independently predicts mortality in falciparum malaria. It is unknown whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria. Methods: This phase 2, open-label, randomized controlled trial conducted at two ...
Richard J. Maude, Frederik Barkhof, Mahtab Uddin Hassan, Aniruddha Ghose et al.
BACKGROUND: Magnetic resonance imaging (MRI) allows detailed study of structural and functional changes in the brain in patients with cerebral malaria. METHODS: In a prospective observational study in adult Bangladeshi patients with severe falciparum malaria, MRI findings in the brain were correlate...
Richard J. Maude, Kamolrat Silamut, Katherine Plewes, Prakaykaew Charunwatthana et al.
BACKGROUND: Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated f...
Josh Hanson, Amir Hossain, Prakaykaew Charunwatthana, Mahtab Uddin Hassan et al.
Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established. Clinical and biochemical data were prospectively collected from 171 consecutive Bangladeshi adults with severe malaria. On admission, 57% of...
Josh Hanson, Amir Hossain, Prakaykaew Charunwatthana, Mahtab Uddin Hassan et al.
Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established. Clinical and biochemical data were prospectively collected from 171 consecutive Bangladeshi adults with severe malaria. On admission, 57% of...
Rapeephan R. Maude, Aniruddha Ghose, Rasheda Samad, Hanna K de Jong et al.
BACKGROUND: Fever is a common cause of hospital admission in Bangladesh but causative agents, other than malaria, are not routinely investigated. Enteric fever is thought to be common. METHODS: Adults and children admitted to Chittagong Medical College Hospital with a temperature of ≥38.0 °C were in...
Md. Golam Rabiul Alam, Tanjim Mushtari Suma, Sk Mahtab Uddin, Md. Bony Amin Khan Siam et al.
Traffic congestion is increasing in over populated urban areas, our traditional traffic management system can no longer solve this problem. However, this problem can be solved by converting our road networks into queueing networks. This paper proposes, the use of an open Jackson Queueing Model which...
Michael Herdman, Natthida Sriboonvorakul, Stije J. Leopold, Sam Douthwaite et al.
INTRODUCTION: Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. METHODS: In this prospective study, we characterised organic acids in adults with s...
Vinayak Joshi, Richard J. Maude, Joseph M. Reinhardt, Li Tang et al.
PURPOSE: To develop an automated method for the detection of retinal hemorrhages on color fundus images to characterize malarial retinopathy, which may help in the assessment of patients with cerebral malaria. METHODS: A fundus image dataset from 14 patients (200 fundus images, with an average of 14...
Natthida Sriboonvorakul, Aniruddha Ghose, Md Mahtab Uddin Hassan, Md Amir Hossain et al.
BACKGROUND: In severe falciparum malaria metabolic acidosis and acute kidney injury (AKI) are independent predictors of a fatal outcome in all age groups. The relationship between plasma acids, urine acids and renal function was investigated in adult patients with acute falciparum malaria. METHODS: ...
Rajat Sanker Roy Biswas, Sujat Paul, Md Ridwanur Rahaman, Md. Abu Sayeed et al.
Background: Chronic Obstructive Pulmonary Disease (COPD) is of public health importance. Indoor biomass (wood, cowdung etc) smoke exposure from cooking is associated with respiratory conditions and may predispose to COPD. The objective of this study was to evaluate the risk of biomass smoke exposure...
Richard J. Maude, Mahtab Uddin Hassan, Nicholas A. V. Beare
A composite digital photograph of the right retina of a 24-year-old Bangladeshi man with non-fatal cerebral malaria was taken on admission to hospital (Figure 1). He presented with 1 day of unconsciousness, pulmonary edema, and blackwater fever. Peripheral blood parasitemia was 79 Plasmodium falcipa...