Shiv Kumar Sarin, Manoj Kumar, George Lau, Zaigham Abbas et al.
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available ...
Shiv Kumar Sarin, Chandan Kumar Kedarisetty, Zaigham Abbas, Deepak Amarapurkar et al.
The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. Due to the rapid advancements in the knowledge and available information, a consortium of members from co...
Shiv Kumar Sarin, Ashok Choudhury, Manoj K. Sharma, Rakhi Maiwall et al.
The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the “APASL ACLF Research Consortium (AARC)” was formed in...
Shiv Kumar Sarin, Ashok Choudhury, George Lau, Ming‐Hua Zheng et al.
Background and aims COVID-19 is a dominant pulmonary disease, with multisystem involvement, depending upon comorbidities. Its profile in patients with pre-existing chronic liver disease (CLD) is largely unknown. We studied the liver injury patterns of SARS-Cov-2 in CLD patients, with or without cirr...
Gamal Shiha, Alaa Ibrahim, Ahmed Helmy, Shiv Kumar Sarin et al.
Hepatic fibrosis is a common pathway leading to liver cirrhosis, which is the end result of any injury to the liver. Accurate assessment of the degree of fibrosis is important clinically, especially when treatments aimed at reversing fibrosis are being evolved. Despite the fact that liver biopsy (LB...
Masao Omata, Tatsuo Kanda, Lai Wei, Ming‐Lung Yu et al.
The Asian-Pacific Association for the Study of the Liver (APASL) convened an international working party on the "APASL consensus statements and recommendation on management of hepatitis C" in March, 2015, in order to revise "APASL consensus statements and management algorithms for hepatitis C virus ...
Prabhakar Semwal, Sakshi Painuli, Tareq Abu‐Izneid, Abdur Rauf et al.
contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation...
Tatsuo Kanda, George Lau, Lai Wei, Mitsuhiko Moriyama et al.
In the direct-acting antiviral (DAA) era for hepatitis C virus (HCV) infection, sustained virological response (SVR) is very high, but close attention must be paid to the possible occurrence of hepatocellular carcinoma (HCC) and reactivation of hepatitis B virus (HBV) in patients with co-infection w...
Masao Omata, Tatsuo Kanda, Lai Wei, Ming‐Lung Yu et al.
The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on "APASL consensus statements and recommendations for management of hepatitis C" in March 2015 to revise the "APASL consensus statements and management algorithms for hepatitis C virus infection...
Ashok Choudhury, Manoj Kumar, Barjesh Chander Sharma, Rakhi Maiwall et al.
BACKGROUND AND AIM: Systemic inflammatory response syndrome (SIRS) is an early marker of sepsis and ongoing inflammation and has been reported in large proportion of acute-on-chronic liver failure (ACLF) patients. Whether sepsis is the cause or the result of liver failure is unclear and is vital to ...
Harshad Devarbhavi, Ashok Choudhury, Manoj Kumar Sharma, Rakhi Maiwall et al.
OBJECTIVES: Acute insults from viruses, infections, or alcohol are established causes of decompensation leading to acute-on-chronic liver failure (ACLF). Information regarding drugs as triggers of ACLF is lacking. We examined data regarding drugs producing ACLF and analyzed clinical features, labora...
Lovkesh Anand, Ashok Choudhury, Chhagan Bihari, Barjesh Chander Sharma et al.
Autoimmune hepatitis (AIH) is considered less common in the Asia Pacific region. Due to this, AIH flare as a cause of acute on chronic liver failure (ACLF) is often overlooked and treatment delayed. We aimed at the defining clinical and histopathological spectrum and role of steroid therapy in AIH-A...
Sandeep Kumar, Surendra Kumar Sharma, Sanjay Kumar Thakral, Krishan Kumar Bhardwaj et al.
Enhancing nutrient use efficiencies (NUEs) is an important factor in achieving the long-term sustainability of a production system. Our two-year experiment was aimed at accessing the NUEs of the integration of macro- and micronutrient fertilization responses of three lentil (Lens culinaris) cultivar...
Mohammad Mahfuz Ali Khan Shawan, Ashish Ranjan Sharma, Manojit Bhattacharya, Bidyut Mallik et al.
The devastating outbreak of COVID-19 has spread all over the world and has become a global health concern. There is no specific therapeutics to encounter the COVID-19. Small interfering RNA (siRNA)-based therapy is an efficient strategy to control human viral infections employing post-transcriptiona...
Anmol Gupta, Priya Dubey, Manoj Kumar, Aditi Roy et al.
Arsenic contamination in water and soil is becoming a severe problem. It is toxic to the environment and human health. It is usually found in small quantities in rock, soil, air, and water which increase due to natural and anthropogenic activities. Arsenic exposure leads to several diseases such as ...