Jena Hamadani, Fahmida Tofail, Barbro Nermell, Renee M. Gardner et al.
BACKGROUND: Exposure to arsenic through drinking water has been associated with impaired cognitive function in school-aged children in a few cross-sectional studies; however, there is little information on critical windows of exposur METHODS: We conducted a population-based longitudinal study in r...
Sultan Ahmed, Sultana Mahabbat-e Khoda, Rokeya Sultana Rekha, Renee M. Gardner et al.
BACKGROUND: Arsenic (As) exposure during pregnancy induces oxidative stress and increases the risk of fetal loss and low birth weight. OBJECTIVES: In this study we aimed to elucidate the effects of As exposure on immune markers in the placenta and cord blood, and the involvement of oxidative stress....
Afruna Rahman, Marie Vahter, Allan H. Smith, Barbro Nermell et al.
The authors evaluated the association of prenatal arsenic exposure with size at birth (birth weight, birth length, head and chest circumferences). This prospective cohort study, based on 1,578 mother-infant pairs, was conducted in Matlab, Bangladesh, in 2002-2003. Arsenic exposure was assessed by an...
Anna‐Lena Lindberg, Eva-Charlotte Ekström, Barbro Nermell, Mahfuzar Rahman et al.
Although genetic polymorphisms have been shown to explain some of the large variation observed in the metabolism of inorganic arsenic there may be several other factors playing an important role, e.g. nutrition. The objective of this study was to elucidate the influence of various factors on current...
Afruna Rahman, Marie Vahter, Eva‐Charlotte Ekström, Md Mijanur Rahman et al.
The authors evaluated the effect of arsenic exposure on fetal and infant survival in a cohort of 29,134 pregnancies identified by the health and demographic surveillance system in Matlab, Bangladesh, in 1991-2000. Arsenic exposure, reflected by drinking water history and analysis of arsenic concentr...
Maria Kippler, Fahmida Tofail, Jena Hamadani, Renee M. Gardner et al.
BACKGROUND: Cadmium is a commonly occurring toxic food contaminant, but health consequences of early-life exposure are poorly understood. OBJECTIVES: We evaluated the associations between cadmium exposure and neurobehavioral development in preschool children. METHODS: In our population-based mother-...
Maria Kippler, Fahmida Tofail, Renee M. Gardner, Anisur Rahman et al.
BACKGROUND: Cadmium (Cd) is an embryotoxic and teratogenic metal in a variety of animal species, but data from humans are limited. OBJECTIVES: The aim of the present study was to assess the effects of maternal Cd exposure in pregnancy on size at birth. METHODS: This prospective cohort study was nest...
Maria Kippler, A.M. Waheedul Hoque, Rubhana Raqib, Helena Öhrvik et al.
Cadmium (Cd) is a widespread, highly toxic environmental pollutant known to accumulate in human placenta. The aim of the present study was to elucidate to what extent the accumulation of Cd in human placenta interacts with the transport of micronutrients to the fetus. Cd and micronutrients were meas...
Barbro Nermell, Anna‐Lena Lindberg, Mahfuzar Rahman, Marika Berglund et al.
This study aims at evaluating the suitability of adjusting urinary concentrations of arsenic, or any other urinary biomarker, for variations in urine dilution by creatinine and specific gravity in a malnourished population. We measured the concentrations of metabolites of inorganic arsenic, creatini...
Rubhana Raqib, Sultan Ahmed, Rokeya Sultana, Yukiko Wagatsuma et al.
Chronic exposure to arsenic, a potent carcinogen and toxicant, via drinking water is a worldwide public health problem. Because little is known about early-life effects of arsenic on immunity, we evaluated the impact of in utero exposure on infant immune parameters and morbidity in a pilot study. Pr...
Maria Kippler, Karin Engström, Simona Jurković Mlakar, Matteo Bottai et al.
Dietary cadmium exposure was recently found to alter DNA methylation in adults, but data on effects early in life are lacking. Our objective was to evaluate associations between prenatal cadmium exposure, DNA methylation and birth weight. In total 127 mother-child pairs from rural Bangladesh were st...
Anisur Rahman, Marie Vahter, Eva‐Charlotte Ekström, Lars Åke Persson
BACKGROUND: Previous studies have reported associations between prenatal arsenic exposure and increased risk of infant mortality. An increase in infectious diseases has been proposed as the underlying cause of these associations, but there is no epidemiologic research to support the hypothesis. OBJE...
Anisur Rahman, Lars Åke Persson, Barbro Nermell, Shams El Arifeen et al.
BACKGROUND: Millions of people worldwide are drinking water with elevated arsenic concentrations. Epidemiologic studies, mainly cross-sectional in design, have suggested that arsenic in drinking water may affect pregnancy outcome and infant health. We assessed the association of arsenic exposure wit...
Karin Engström, Marie Vahter, Simona Jurković Mlakar, Gabriela Concha et al.
BACKGROUND: Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in humans, and the methylation pattern demonstrates large interindividual differences. The fraction of urinary MMA is a marker for susceptibility to As-related diseases. OBJECTIVES: We evaluated the impact...
Renee M. Gardner, Maria Kippler, Fahmida Tofail, Matteo Bottai et al.
In this prospective cohort study, based on 1,505 mother-infant pairs in rural Bangladesh, we evaluated the associations between early-life exposure to arsenic, cadmium, and lead, assessed via concentrations in maternal and child urine, and children's weights and heights up to age 5 years, during the...