Salim Yusuf, Philip Joseph, Sumathy Rangarajan, Shofiqul Islam et al.
Background: Global estimates of the impact of common modifiable risk factors on cardiovascular disease (CVD) and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban Rural Epidemiology (PURE) study overcomes these limitations by using simila...
Martin O’Donnell, Andrew Mente, Sumathy Rangarajan, Matthew McQueen et al.
BACKGROUND: The optimal range of sodium intake for cardiovascular health is controversial. METHODS: We obtained morning fasting urine samples from 101,945 persons in 17 countries and estimated 24-hour sodium and potassium excretion (used as a surrogate for intake). We examined the association betwee...
Andrew Mente, Martin O’Donnell, Sumathy Rangarajan, Matthew McQueen et al.
BACKGROUND: Higher levels of sodium intake are reported to be associated with higher blood pressure. Whether this relationship varies according to levels of sodium or potassium intake and in different populations is unknown. METHODS: We studied 102,216 adults from 18 countries. Estimates of 24-hour ...
Andrew Mente, Martin O’Donnell, Sumathy Rangarajan, Gilles R. Dagenais et al.
BACKGROUND Several studies reported a U-shaped association between urinary sodium excretion and cardiovascular disease events and mortality. Whether these associations vary between those individuals with and without hypertension is uncertain. We aimed to explore whether the association between sodiu...
Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang, Matthew C. Hibberd et al.
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutr...
Andrew Mente, Martin O’Donnell, Sumathy Rangarajan, Matthew McQueen et al.
BACKGROUND WHO recommends that populations consume less than 2 g/day sodium as a preventive measure against cardiovascular disease, but this target has not been achieved in any country. This recommendation is primarily based on individual-level data from short-term trials of blood pressure (BP) with...
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Matthew McQueen et al.
Background The relation between dietary nutrients and cardiovascular disease risk markers in many regions worldwide is unknown. In this study, we investigated the effect of dietary nutrients on blood lipids and blood pressure, two of the most important risk factors for cardiovascular disease, in low...
Marjan Walli-Attaei, Rasha Khatib, Martin McKee, Scott A. Lear et al.
BACKGROUND: Hypertension is considered the most important risk factor for cardiovascular diseases, but its control is poor worldwide. We aimed to assess the availability and affordability of blood pressure-lowering medicines, and the association with use of these medicines and blood pressure control...
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Martin O’Donnell et al.
AIMS: To develop a healthy diet score that is associated with health outcomes and is globally applicable using data from the Prospective Urban Rural Epidemiology (PURE) study and replicate it in five independent studies on a total of 245 000 people from 80 countries. METHODS AND RESULTS: A healthy d...
Deepa Mohan, Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan et al.
Importance: Cohort studies report inconsistent associations between fish consumption, a major source of long-chain ω-3 fatty acids, and risk of cardiovascular disease (CVD) and mortality. Whether the associations vary between those with and those without vascular disease is unknown. Objective: To ex...
Martin O’Donnell, Andrew Mente, Sumathy Rangarajan, Matthew McQueen et al.
OBJECTIVE: To evaluate the joint association of sodium and potassium urinary excretion (as surrogate measures of intake) with cardiovascular events and mortality, in the context of current World Health Organization recommendations for daily intake (<2.0 g sodium, >3.5 g potassium) in adults. DESIGN:...
Adrianna Murphy, Benjamin Palafox, Owen O’Donnell, David Stückler et al.
BACKGROUND: There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. METHODS: We assessed use of antiplatelet, cholesterol, and blood-pressure-lowering drugs in 8492 individuals ...
Thirunavukkarasu Sathish, Koon Teo, Philip Britz‐McKibbin, Biban Gill et al.
BACKGROUND: Separate studies suggest that the risks from smoking might vary between high-income (HICs), middle-income (MICs), and low-income (LICs) countries, but this has not yet been systematically examined within a single study using standardised approaches. We examined the variations in risks fr...
Raed A. Joundi, Bo Hu, Sumathy Rangarajan, Darryl P. Leong et al.
BACKGROUND The focus of most epidemiological studies has been mortality or clinical events, with less information on activity limitations related to basic daily functions and their consequences. Standardised data from multiple countries at different economic levels in different regions of the world ...
Darryl P. Leong, Rita Yusuf, Romaina Iqbal, Álvaro Avezum et al.
BACKGROUND: Current strategies to prevent adverse cardiovascular outcomes focus primary prevention in high-risk groups and secondary prevention in people with known cardiovascular disease. We aimed to determine the proportion of events occurring in lower-risk groups globally. METHODS: We included pe...