Yu Chen, Faruque Parvez, Mary V. Gamble, Tariqul Islam et al.
The contamination of groundwater by arsenic in Bangladesh is a major public health concern affecting 35-75 million people. Although it is evident that high levels (>300 microg/L) of arsenic exposure from drinking water are related to adverse health outcomes, health effects of arsenic exposure at low...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Chronic exposure to arsenic is occurring throughout South and East Asia due to groundwater contamination of well water. Variability in susceptibility to arsenic toxicity may be related to nutritional status. Arsenic is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via one...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Background Populations in South and East Asia and many other regions of the world are chronically exposed to arsenic-contaminated drinking water. To various degrees, ingested inorganic arsenic (InAs) is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via folate-dependent on...
Habibul Ahsan, Yu Chen, Muhammad G. Kibriya, Vesna Slavkovich et al.
We conducted a case-control study to investigate interindividual variability in susceptibility to health effects of inorganic arsenic due to arsenic metabolism efficiency, genetic factors, and their interaction. A total of 594 cases of arsenic-induced skin lesions and 1,041 controls was selected fro...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
Background Studies in cell culture and animal models indicate that arsenic exposure induces modifications in DNA methylation, including genome-wide DNA hypomethylation. It is not known whether arsenic exposure influences genomic DNA methylation in human populations chronically exposed to arsenic-con...
Brandon L. Pierce, Muhammad G. Kibriya, Tong Lin, Farzana Jasmine et al.
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer. There is inter-individual variation in arsenic metabolism efficiency and susceptibility to arsenic toxicity; however, the basis of this variation ...
Marni Hall, Mary V. Gamble, Vesna Slavkovich, Xinhua Liu et al.
BACKGROUND: In Bangladesh, tens of millions of people have been consuming waterborne arsenic for decades. The extent to which As is transported to the fetus during pregnancy has not been well characterized. OBJECTIVES: We therefore conducted a study of 101 pregnant women who gave birth in Matlab, Ba...
J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
BACKGROUND: An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown. OBJECTIVE: The objective of this study was to investigate the influence of prenat...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
BACKGROUND: Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility. OBJECTIVE: A...
Julia E. Heck, Mary V. Gamble, Yu Chen, Joseph H. Graziano et al.
Background Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser ...
Yana Chervona, Megan N. Hall, Adriana Arita, Fen Wu et al.
BACKGROUND: Exposure to arsenic (As) is associated with an increased risk of several cancers as well as cardiovascular disease, and childhood neuro-developmental deficits. Arsenic compounds are weakly mutagenic, alter gene expression and posttranslational histone modifications (PTHMs) in vitro. METH...
Mary V. Gamble, Habibul Ahsan, Xinhua Liu, Pam Factor‐Litvak et al.
Background Indian Asian men residing in the United Kingdom have a higher prevalence of hyperhomocysteinemia than do their European counterparts. This has been largely attributed to dietary deficiencies in cobalamin associated with vegetarianism among these Indian Asians. Objective We aimed to ascert...
Brandilyn A. Peters, Megan N. Hall, Xinhua Liu, Faruque Parvez et al.
BACKGROUND: The World Health Organization estimates that > 140 million people worldwide are exposed to arsenic (As)-contaminated drinking water. As undergoes biologic methylation, which facilitates renal As elimination. In folate-deficient individuals, this process is augmented by folic acid (FA) su...
Megan N. Hall, Xinhua Liu, Vesna Slavkovich, Vesna Ilievski et al.
BACKGROUND: Approximately 35 million people in Bangladesh are chronically exposed to inorganic arsenic (InAs) in drinking water. Methylation of InAs to monomethylarsonic (MMA) and dimethylarsinic acids (DMA) relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic (uAs) elimi...
J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Habibul Ahsan et al.
BACKGROUND: Global hypomethylation of DNA is thought to constitute an early event in some cancers and occurs in response to arsenic (As) exposure and/or selenium (Se) deficiency in both in vitro and animal models. In addition, antagonism between As and Se, whereby each reduces toxicity of the other,...