Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang, Matthew C. Hibberd et al.
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutr...
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHOD...
Arjun S. Raman, Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang et al.
Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbi...
Robert Y. Chen, Vanderlene L. Kung, Subhasish Das, Md. Shabab Hossain et al.
BACKGROUND: Environmental enteric dysfunction (EED) is an enigmatic disorder of the small intestine that is postulated to play a role in childhood undernutrition, a pressing global health problem. Defining the incidence of this disorder, its pathophysiological features, and its contribution to impai...
Michael J. Barratt, Sharika Nuzhat, Kazi Ahsan, Steven A. Frese et al.
Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. Bifidobacterium longum subspecies infantis is a prominent early colonizer of the infant gut that consumes human milk oligosaccharides (HMOs). We found that the absolute abundance of Bifidobacterium infanti...
Carrie A. Cowardin, Philip P. Ahern, Vanderlene L. Kung, Matthew C. Hibberd et al.
Undernutrition in children is a pressing global health problem, manifested in part by impaired linear growth (stunting). Current nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need to obtain better understanding of its underlying causes. Treating Bang...
Matthew C. Hibberd, Daniel M. Webber, Dmitry A. Rodionov, Suzanne Henrissat et al.
Abstract Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition 1–4 . Here we analyse biospecimens from a randomized, controlled trial of a microbiome-directed complementary food (MDCF-2) that produced superior rates of weight gain c...
Hao-Wei Chang, Evan M. Lee, William Yi Wang, Cyrus Zhou et al.
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, improved weight gain in malnourished Bangladeshi children compared to a more calorically dens...
Ishita Mostafa, Matthew C. Hibberd, Steven J. Hartman, Md Hasan Hafizur Rahman et al.
BACKGROUND: Globally, stunting affects ∼150 million children under five, while wasting affects nearly 50 million. Current interventions have had limited effectiveness in ameliorating long-term sequelae of undernutrition including stunting, cognitive deficits and immune dysfunction. Disrupted develop...
Aleksandr A. Arzamasov, Dmitry A. Rodionov, Matthew Charles Hibberd, Janaki L. Guruge et al.
Bifidobacteria are beneficial saccharolytic microbes that are widely used as probiotics or in synbiotic formulations, yet individual responses to supplementation can vary with strain type, microbiota composition, diet and lifestyle, underscoring the need for strain-level insights into glycan metabol...
Steven J. Hartman, Matthew C. Hibberd, Ishita Mostafa, Nurun Nahar Naila et al.
Globally, severe acute malnutrition (SAM), defined as a weight-for-length z -score more than three SDs below a reference mean (WLZ < −3), affects 14 million children under 5 years of age. Complete anthropometric recovery after standard, short-term interventions is rare, with children often left w...
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.
Kali M. Pruss, C.-Y. Kao, Alexandra Byrne, Robert Y. Chen et al.
Environmental enteric dysfunction (EED), a small intestinal disorder found at a high prevalence in stunted children, is associated with gut mucosal barrier disruption and decreased absorptive capacity. To test the hypothesis that intergenerational transmission of a perturbed small intestinal microbi...
Ishita Mostafa, Matthew C. Hibberd, Steven J. Hartman, Md Hasan Hafizur Rahman et al.
SUMMARY Background Globally, stunting affects ∼150 million children under five, while wasting affects nearly 50 million. Current interventions have had limited effectiveness in ameliorating long-term sequelae of undernutrition including stunting, cognitive deficits and immune dysfunction. Disrupted ...
Cyrus Zhou, Matthew Charles Hibberd, Evan M. Lee, Bo Pilgaard et al.
Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation prod...