Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang, Matthew C. Hibberd et al.
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutr...
Md. Milon Islam, Md. Rezwanul Haque, Hasib Iqbal, Md. Munirul Hasan et al.
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHOD...
Margaret Kosek, Tahmeed Ahmed, Zulfiqar A Bhutta, Laura E. Caulfield et al.
BACKGROUND: Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populati...
ASG Faruque, AM Shamsir Ahmed, Tahmeed Ahmed, M Munirul Islam et al.
Recent data from the World Health Organization showed that about 60% of all deaths, occurring among children aged less than five years (under-five children) in developing countries, could be attributed to malnutrition. It has been estimated that nearly 50.6 million under-five children are malnourish...
Michael J. Barratt, Sharika Nuzhat, Kazi Ahsan, Steven A. Frese et al.
Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. Bifidobacterium longum subspecies infantis is a prominent early colonizer of the infant gut that consumes human milk oligosaccharides (HMOs). We found that the absolute abundance of Bifidobacterium infanti...
Baitun Nahar, Muttaquina Hossain, Mustafa Mahfuz, M Munirul Islam et al.
Information on the association between stunting and child development is limited from low-income settings including Bangladesh where 36% of children under- 5 are stunted. This study aimed to explore differences in early childhood development (ECD) between stunted (length-for-age z-score [LAZ] < -2) ...
James A Platts-Mills, Mami Taniuchi, Md. Jashim Uddin, Shihab U. Sobuz et al.
Background: Early exposure to enteropathogens has been associated with malnutrition in children in low-resource settings. However, the contribution of individual enteropathogens remains poorly defined. Molecular diagnostics offer an increase in sensitivity for detecting enteropathogens but have not ...
Tahmeed Ahmed, Mustafa Mahfuz, Md Munirul Islam, Dinesh Mondal et al.
The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study site in Bangladesh is located in the capital city of Dhaka in an urban slum that has one of the highest population densities in the world. The site ...
Luisa F. Angeles, Shamim Islam, Jared Aldstadt, Kazi Nazmus Saqeeb et al.
Densely populated countries in Asia, such as Bangladesh, are considered to be major contributors to the increased occurrence of global antimicrobial resistance (AMR). Several factors make low-and middle-income countries vulnerable to increased emergence and spread of AMR in the environment including...
Munirul Alam, Atiqul Islam, NurulA. Bhuiyan, Md Niaz Rahim et al.
Vibrio cholerae is an estuarine bacterium associated with a single peak of cholera (March-May) in coastal villages of Bangladesh. For an unknown reason, however, cholera occurs in a unique dual peak (March-May and September-November) pattern in the city of Dhaka that is bordered by a heavily pollute...
Daniel Roth, Alison D. Gernand, Shaun K. Morris, Brendon Pezzack et al.
BACKGROUND: Vitamin D regulates bone mineral metabolism and skeletal development. Some observational studies have suggested that prenatal vitamin D deficiency increases the risk of adverse pregnancy and/or birth outcomes; however, there is scant evidence from controlled trials, leading the World Hea...
M Munirul Islam, Makhduma Khatun, Janet M Peerson, Tahmeed Ahmed et al.
Background Information is needed on the minimum energy density and feeding frequency of complementary foods that can provide adequate energy intakes (EIs) for healthy breastfed children. Objectives The objectives of the study were to evaluate the effects of various energy densities and feeding frequ...
Fatema-Tuz Johura, Rozina Parveen, Atiqul Islam, Abdus Sadique et al.
Shiga-toxin producing Escherichia coli (STEC) and enterotoxigenic E. coli (ETEC) are important causes of diarrhea in humans and animals worldwide. Although ruminant animals are the main source of STEC, diarrhea due to this pathotype is very low in Bangladesh where ETEC remains the predominant group ...
Md Mamun Monir, Mohammad Tarequl Islam, Razib Mazumder, Dinesh Mondal et al.
Abstract In 2022, one of its worst cholera outbreaks began in Bangladesh and the icddr,b Dhaka hospital treated more than 1300 patients and ca. 42,000 diarrheal cases from March-1 to April-10, 2022 1 . Here, we present genomic attributes of V. cholerae O1 responsible for the 2022 Dhaka outbreak and ...