Ema Rodrigues, David C. Bellinger, Linda Valeri, Md Omar Sharif Ibne Hasan et al.
BACKGROUND: The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmen...
Lindsay M. Jaacks, Nancy Diao, Antonia M. Calafat, María Ospina et al.
BACKGROUND: Pesticide exposure during pregnancy is thought to adversely affect fetal growth, which in turn may impact child growth, but results have been inconsistent across studies and few have explored these effects in developing countries. OBJECTIVES: To quantify urinary concentrations of pestici...
Kelsey Gleason, James P. Shine, Nadia Shobnam, Lisa B. Rokoff et al.
BACKGROUND: During the conduct of a cohort study intended to study the associations between mixed metal exposures and child health outcomes, we found that 78% of 309 children aged 20-40 months evaluated in the Munshiganj District of Bangladesh had blood lead concentrations ≥5 µg/dL and 27% had conce...
Maitreyi Mazumdar, Md Omar Sharif Ibne Hasan, Rezina Hamid, Linda Valeri et al.
BACKGROUND: Arsenic induces neural tube defects in several animal models, but its potential to cause neural tube defects in humans is unknown. Our objective was to investigate the associations between maternal arsenic exposure, periconceptional folic acid supplementation, and risk of posterior neura...
Kelsey Gleason, Linda Valeri, Anuraj H. Shankar, Md Omar Sharif Ibne Hasan et al.
BACKGROUND: Lead toxicity is of particular public health concern given its near ubiquitous distribution in nature and established neurotoxicant properties. Similar in its ubiquity and ability to inhibit neurodevelopment, early childhood stunting affects an estimated 34 % of children under 5 in low- ...
Vijaya Kancherla, Md Omar Sharif Ibne Hasan, Rezina Hamid, Ligi Paul et al.
Neural tube defects contribute to severe morbidity and mortality in children and adults; however, they are largely preventable through maternal intake of folic acid before and during early pregnancy. We examined the association between maternal prenatal folic acid supplement intake and risk of myelo...
Maitreyi Mazumdar, Linda Valeri, Ema Rodrigues, Md Omar Sharif Ibne Hasan et al.
BACKGROUND Arsenic induces neural tube defects in many animal models. Additionally, studies have shown that mice with specific genetic defects in folate metabolism and transport are more susceptible to arsenic‐induced neural tube defects. We sought to determine whether 14 single‐nucleotide polymorph...
Jannah Tauheed, Marco Sánchez-Guerra, Jane Lee, Ligi Paul et al.
Arsenic exposure may contribute to disease risk in humans through alterations in the epigenome. Previous studies reported that arsenic exposure is associated with changes in plasma histone concentrations. Posttranslational histone modifications have been found to differ between the brain tissue of h...
Barrett M. Welch, Adam J. Branscum, Sharia M. Ahmed, Perry Hystad et al.
BACKGROUND: Arsenic can impair immune function. Timing of exposure can influence potential immunotoxicity of arsenic exposure. We examined the association between drinking water arsenic concentrations (W-As) measured repeatedly during different exposure windows in early life and serum concentrations...
Jane J Lee, Linda Valeri, Kush Kapur, Md Omar Sharif Ibne Hasan et al.
Background: Our previous study demonstrated that prenatal manganese exposure is associated with cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children. This study tested the hypothesis that the adverse effects of manganese are mediated through poor prenatal growth. Methods: Pr...
May Woo, Elisabeth S. Young, Md. Golam Mostofa, Sakila Afroz et al.
Previous evaluations of a birth cohort in the Munshiganj District of Bangladesh had found that over 85% of 397 children aged 2⁻3 years had blood lead concentrations above the United States Centers for Disease Control and Prevention's reference level of 5 μg/dL. Studies in urban areas of Bangladesh h...
Kelsey Gleason, Linda Valeri, Anuraj H. Shankar, John F. Obrycki et al.
BACKGROUND: Many children in Bangladesh experience poor nutritional status and environmental lead exposure, both of which are associated with lower scores on neurodevelopmental assessments. Recent studies have suggested that part of lead's adverse effects on neurodevelopment are caused in part by le...
John F. Obrycki, Jane J. Lee, Kush Kapur, Ligi Paul et al.
OBJECTIVES: Mothers need a nutrient-rich diet for healthy neural tube development. Neural tube defect risk can be reduced through fortifying grain products with folic acid and taking folic acid supplements. Fortification is not required in Bangladesh. Maternal supplement use rates are low, similar t...
Jane J. Lee, Kush Kapur, Ema Rodrigues, Md Omar Sharif Ibne Hasan et al.
Among a cohort of children located in rural areas of Bangladesh affected by high levels of exposure to environmental metals, we investigated the associations between anthropometric measures, growth trajectory, and neurodevelopment at age 20–40 months. Our study population included mothers and their ...
Lilia Bliznashka, Nancy Diao, David Christiani, Antonia M. Calafat et al.
Pesticides are an often-overlooked dietary exposure, especially in low- and middle-income countries (LMICs). Evidence from high-income settings indicates that pesticide exposure during pregnancy can adversely affect early childhood development (ECD). However, evidence from LMICs is limited. Our obje...