Yusha Araf, F. Akter, Yan‐Dong Tang, Rabeya Fatemi et al.
Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide as an Omicron variant. This variant is a heavily mutated virus and designated as a variant of concern by the World Health Organization (WHO). WHO cautioned that the Omicron variant of SARS-CoV-2 held a very ...
Md Sorwer Alam Parvez, Md. Adnan Karim, Mahmudul Hasan, Jomana Jaman et al.
The pandemic prevalence of COVID-19 has become a very serious global health issue. Scientists all over the world have been seriously attempting in the discovery of a drug to combat SARS-CoV-2. It has been found that RNA-dependent RNA polymerase (RdRp) plays a crucial role in SARS-CoV-2 replication, ...
Yusha Araf, Abu Tayab Moin, В. И. Тимофеев, Nairita Ahsan Faruqui et al.
Mucormycosis is a potentially fatal illness that arises in immunocompromised people due to diabetic ketoacidosis, neutropenia, organ transplantation, and elevated serum levels of accessible iron. The sudden spread of mucormycosis in COVID-19 patients engendered massive concern worldwide. Comorbiditi...
Md Sorwer Alam Parvez, Gen Ohtsuki
The cerebellum governs motor coordination and motor learning. Infection with external microorganisms, such as viruses, bacteria, and fungi, induces the release and production of inflammatory mediators, which drive acute cerebellar inflammation. The clinical observation of acute cerebellitis is assoc...
Mahmudul Hasan, Md Sorwer Alam Parvez, Kazi Faizul Azim, Md. Abdus Shukur Imran et al.
Here, drug repurposing and molecular docking were employed to screen approved MPP inhibitors and their derivatives to suggest a specific therapeutic agent for the treatment of COVID-19. The approved MPP inhibitors against HIV and HCV were prioritized, while RNA dependent RNA Polymerase (RdRp) inhibi...
Rahatul Islam, Md Sorwer Alam Parvez, Saeed Anwar, Mohammad Jakir Hosen
Dengue is one of the most common life-threatening neglected tropical diseases of the world, therapeutics for whose treatment and prevention still remains undeveloped. Despite having been licensed, the existing vaccine (Dengvaxia) is rather inefficacious due to the presence of multiple serovars of th...
Mahmudul Hasan, Kazi Faizul Azim, Md. Abdus Shukur Imran, Ishtiak Malique Chowdhury et al.
Multidrug-resistant Vibrio parahaemolyticus has become a significant public health concern. The development of effective drugs and vaccines against Vibrio parahaemolyticus is the current research priority. Thus, we aimed to find out effective drug and vaccine targets using a comprehensive genome-bas...
Md Sorwer Alam Parvez, Mohammad Mahfujur Rahman, Md. Niaz Morshed, Dolilur Rahman et al.
As the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), rages across the world, killing hundreds of thousands and infecting millions, researchers are racing against time to elucidate the viral genome. Some Bangladeshi institutes are als...
Md. Firose Hossain, Mu’tasim Billah, Md Roushan Ali, Md Sorwer Alam Parvez et al.
Ralstonia solanacearum is a harmful pathogen that causes severe wilt disease in several vegetables. In the present study, we identified R. solanacearum from wilt of papaya by 16S rRNA PCR amplification. Virulence ability of R. solanacearum was determined by amplification of approximately 1500 bp cle...
Md Sorwer Alam Parvez, Dolilur Rahman
In order for a successful infection and creating a satisfactory environment inside the host, strains of uropathogenic Escherichia coli (UPEC) need some special features that are achieved by expressing particular genes, called virulence factors. Two of the most important surface virulence factors of ...
Nazma Shaheen, Afiatul Azam, Amlan Ganguly, Saeed Anwar et al.
Abstract Background Black cumin ( Nigella sativa ) is a widely used ingredient of traditional medicine for its broad-spectrum pharmacological actions, including analgesic, bronchial asthma, anti-inflammatory properties, and others. We sought to evaluate BC extracts' efficacy for the anti-inflammator...
Md Sorwer Alam Parvez, Manash Kumar Saha, Md. Ibrahim, Yusha Araf et al.
INTRODUCTION: Prominently accountable for the upsurge of COVID-19 cases as the world attempts to recover from the previous two waves, Omicron has further threatened the conventional therapeutic approaches. The lack of extensive research regarding Omicron has raised the need to establish correlations...
Syeda Farjana Hoque, Md. Nazmul Islam Bappy, Anjum Taiebah Chowdhury, Md Sorwer Alam Parvez et al.
Abstract Monkeypox is a zoonotic disease caused by monkeypox virus with noteworthy mortality and morbidity. Several recent outbreaks and the need of dependable reconnaissance have raised the level of concern for this developing zoonosis. In the present study, a reverse vaccinology strategy was devel...
Md. Niaz Morshed, Md Sorwer Alam Parvez, Rakibul Islam Akanda, Manash Kumar Saha et al.
The development of more efficient and durable multi-targeted therapeutic drug against hepatocellular carcinoma (HCC) has recently been of growing interest to tackle chemoresistance. Several studies indicate that increased expression of methyltransferase-like (METTL) proteins, including METTL1, METTL...
Md Sorwer Alam Parvez, Mohammad Mahfujur Rahman, Md. Niaz Morshed, Dolilur Rahman et al.
Abstract As the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), rages across the world, killing hundreds of thousands and infecting millions, researchers are racing against time to elucidate the viral genome. Some Bangladeshi institute...
Mahmudul Hasan, Kazi Faizul Azim, Abdus Shukur Imran, Ishtiak Malique Chowdhury et al.
Abstract Multidrug-resistant Vibrio parahaemolyticus has become a significant threat to human health as well as aquaculture, prioritizing the development of effective drug and vaccine candidates. Hence, the study was designed to identify novel therapeutics using a comprehensive genome-based analysis...
Mahmudul Hasan, Md Sorwer Alam Parvez, Kazi Faizul Azim, Md. Abdus Shukur Imran et al.
<div>The world is facing an unprecedented global pandemic caused by the novel SARS-CoV-2. In the absence</div><div>of a specific therapeutic agent to treat COVID-19 patients, the present study aimed to virtually screen out</div><div>the effective drug candidates from th...
Rahatul Islam, Md Sorwer Alam Parvez, Saeed Anwar, Mohammad Jakir Hosen
Dengue is one of the most common life-threatening neglected tropical diseases of the world, therapeutics for whose treatment and prevention still remains undeveloped. Despite having been licensed, the existing vaccine (Dengvaxia) is rather inefficacious due to the presence of multiple serovars of th...
Md Sorwer Alam Parvez, Mohammad Mahfujur Rahman, Md. Niaz Morshed, Dolilur Rahman et al.
Abstract Transmembrane anterior-posterior transformation protein 1 (TAPT1), encoded by the TAPT1 gene expressed in the basal ciliary body, plays a crucial role in cilia formation as well as axial skeletal patterning. Mutations in this gene have been reported to cause several ciliopathies and osteo-r...
Mahmudul Hasan, Md Sorwer Alam Parvez, Kazi Faizul Azim, Md. Abdus Shukur Imran et al.
The world is facing an unprecedented global pandemic caused by the novel SARS-CoV-2. In the absence of a specific therapeutic agent to treat COVID-19 patients, the present study aimed to virtually screen out the effective drug candidates from the approved main protease protein (MPP) inhibitors and t...