J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
BACKGROUND: An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknow OBJECTIVE: The objective of this study was to investigate the influence of prenat...
Yana Chervona, Megan N. Hall, Adriana Arita, Fen Wu et al.
BACKGROUND: Exposure to arsenic (As) is associated with an increased risk of several cancers as well as cardiovascular disease, and childhood neuro-developmental deficits. Arsenic compounds are weakly mutagenic, alter gene expression and posttranslational histone modifications (PTHMs) in vitro. METH...
Brandilyn A. Peters, Megan N. Hall, Xinhua Liu, Faruque Parvez et al.
BACKGROUND: The World Health Organization estimates that > 140 million people worldwide are exposed to arsenic (As)-contaminated drinking water. As undergoes biologic methylation, which facilitates renal As elimination. In folate-deficient individuals, this process is augmented by folic acid (FA) su...
Megan N. Hall, Xinhua Liu, Vesna Slavkovich, Vesna Ilievski et al.
BACKGROUND: Approximately 35 million people in Bangladesh are chronically exposed to inorganic arsenic (InAs) in drinking water. Methylation of InAs to monomethylarsonic (MMA) and dimethylarsinic acids (DMA) relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic (uAs) elimi...
J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Habibul Ahsan et al.
BACKGROUND: Global hypomethylation of DNA is thought to constitute an early event in some cancers and occurs in response to arsenic (As) exposure and/or selenium (Se) deficiency in both in vitro and animal models. In addition, antagonism between As and Se, whereby each reduces toxicity of the other,...
Megan N. Hall, Megan M. Niedzwiecki, Xinhua Liu, Kristin N. Harper et al.
BACKGROUND: In vitro and rodent studies have shown that arsenic (As) exposure can deplete glutathione (GSH) and induce oxidative stress. GSH is the primary intracellular antioxidant; it donates an electron to reactive oxygen species, thus producing glutathione disulfide (GSSG). Cysteine (Cys) and cy...
Megan M. Niedzwiecki, Megan N. Hall, Xinhua Liu, Julie Oka et al.
Background: Several studies employing cell culture and animal models have suggested that arsenic (As) exposure induces global DNA hypomethylation. However, As has been associated with global DNA hypermethylation in human study populations. We hypothesized that this discrepancy may reflect a nonlinea...
Caitlin G. Howe, Megan M. Niedzwiecki, Megan N. Hall, Xinhua Liu et al.
Chronic exposure to inorganic arsenic (InAs) through drinking water is a major problem worldwide. InAs undergoes hepatic methylation to form mono- and dimethyl arsenical species (MMA and DMA, respectively), facilitating arsenic elimination. Both reactions are catalyzed by arsenic (+3 oxidation state...
Stephanie C. Melkonian, Maria Argos, Megan N. Hall, Yu Chen et al.
BACKGROUND: We utilized data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh, to evaluate the association of steamed rice consumption with urinary total arsenic concentration and arsenical skin lesions in the overall study cohort (N=18,470) and in a subset with...
Anne K. Bozack, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
Background Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion. Arsenic methylation is dependent on one-carbon metabolism, which is influenced ...
Brandilyn A. Peters, Megan N. Hall, Xinhua Liu, Y. Dana Neugut et al.
Kidney disease is emerging as an arsenic (As)-linked disease outcome, however further evidence of this association is warranted. Our first objective for this paper was to examine the potential renal toxicity of As exposure in Bangladesh. Our second objective relates to examining whether the previous...
Megan M. Niedzwiecki, Xinhua Liu, Megan N. Hall, Tiffany Thomas et al.
BACKGROUND: Depletion of global 5-hydroxymethylcytosine (5-hmC) is observed in human cancers and is strongly implicated in skin cancer development. Although arsenic (As)-a class I human carcinogen linked to skin lesion and cancer risk-is known to be associated with changes in global %5-methylcytosin...
Caitlin G. Howe, Xinhua Liu, Megan N. Hall, Vesna Slavkovich et al.
BACKGROUND: Exposure to inorganic arsenic is associated with numerous adverse health outcomes, with susceptibility differing by sex. Although evidence from in vitro studies suggests that arsenic alters post-translational histone modifications (PTHMs), evidence in humans is limited. OBJECTIVES: The o...
Brandilyn A. Peters, Megan N. Hall, Xinhua Liu, Vesna Slavkovich et al.
Background Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators o...
F. Abate, Amanda Adu-Amankwah, KA Ae-Ngibise, Francis Agbokey et al.
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nu...