Md. Shimul Bhuia, Md. Mizanur Rahaman, Tawhida Islam, Mehedi Hasan Bappi et al.
Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databa...
Md. Shimul Bhuia, Hossam Kamli, Tawhida Islam, Fatema Akter Sonia et al.
Current study was conducted to assess the effectiveness of the polyphenol trans-ferulic acid (TFA) as an antiemetic agent using in vivo and in silico methods. To evaluate this, we induced emesis in 3-day-old chicks through the oral administration of copper sulfate (CuSO4·5H2O) at a dose of 50 mg/kg....
Md. Shimul Bhuia, Polrat Wilairatana, Jannatul Ferdous, Raihan Chowdhury et al.
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases and ailments. These food items are prominent sources of phytochemicals that exhibit chemopreventive and therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occ...
Md. Shahazul Islam, Rajib Hossain, Taukir Ahmed, Md. Mizanur Rahaman et al.
Scientific evidence suggests that quercetin (QUR) has anxiolytic-like effects in experimental animals. However, the mechanism of action responsible for its anxiolytic-like effects is yet to be discovered. The goal of this research is to assess QUR's anxiolytic effects in mouse models to explicate th...
Mehedi Hasan Bappi, Md. Nayem Mia, Siddique Akber Ansari, Irfan Aamer Ansari et al.
Abstract Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables demonstrating versatile health‐promoting effects. This study aimed to examine the effects of quercetin (QR) and sclareol (SCL) on the thiopental sodium (TS)‐induced sleeping and forced swimming test (FST) m...
Mehedi Hasan Bappi, Abdullah Al Shamsh Prottay, Hossam Kamli, Fatema Akter Sonia et al.
Sedatives promote calmness or sleepiness during surgery or severely stressful events. In addition, depression is a mental health issue that negatively affects emotional well-being. A group of drugs called anti-depressants is used to treat major depressive illnesses. The aim of the present work was t...
Md. Shimul Bhuia, Md. Sajjad Hossain Siam, Md. Riat Ahamed, Uttam Kumar Roy et al.
Frequent use of various food processing chemical agents sometimes causes damage to our bodies by inducing cytotoxicity, genotoxicity, and mutagenesis. In Bangladesh, among various chemical agents, formalin, saccharin, and urea are vastly used for processing foodstuffs by industry and local people. T...
Abdullah Al Shamsh Prottay, Mehedi Hasan Bappi, Md. Showkoth Akbor, Afia Ibnath Asha et al.
Chronic and severe inflammation results in many diseases and disorders in humans. Currently, available conventional anti-inflammatory drugs have numerous mild-to-severe side effects. Thus, there is a need for safe, effective, affordable, and alternative anti-inflammatory drugs. This study aimed to e...
Muhammad Torequl Islam, Mehedi Hasan Bappi, Md. Shimul Bhuia, Siddique Akber Ansari et al.
Thymol (THY), as the natural monoterpene phenol, acts against oxidative stress and inflammatory processes. This study aimed to evaluate the anti-inflammatory effects and possible molecular mechanisms of THY via formalin-induced mouse and egg albumin-induced chick models alongside molecular docking a...
Muhammad Torequl Islam, Raihan Chowdhury, Md. Sakib Al Hasan, Salehin Sheikh et al.
The diterpenoid phytol is evidently acting against anemia in experimental animals. However, the molecular mechanisms behind this issue are yet to be discovered. This study aimed to evaluate phytol's effect on methotrexate-induced folate-deficient animals through in vivo and in silico studies. For th...
M. Azizul Islam, Abdullah Al Shamsh Prottay, Irin Sultana, Abdullah Al Faruq et al.
Muhammad Torequl Islam, Md. Shimul Bhuia, Salehin Sheikh, Rubel Hasan et al.
The soy isoflavone daidzin (DZN) has been considered a hopeful bioactive compound having diverse biological activities, including anxiolytic, memory-enhancing, and antiepileptic effects, in experimental animals. However, its sedative and hypnotic effects are yet to be discovered. This study aimed to...
Md. Nayem Mia, Shanita Zaman Smrity, Mehedi Hasan Bappi, Hossam Kamli et al.
Mst. Farjanamul Haque, Heba A. S. El‐Nashar, Md. Showkoth Akbor, Mohammed Alfaifi et al.
Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in a chick model. Additionally, in silico studies were performed to evaluate the mo...
Sm Hafiz Hassan, Heba A S El-Nashar, Md. Anisur Rahman, Jannatul Islam Polash et al.
Sclareol (SCL), a labdane diterpene compound found in Salvia sclarea L., exhibited therapeutic effects. This study investigated the potential interaction between SCL and diazepam (DZP) in modulating sedation in the thiopental sodium-induced sleeping animal model, supported by in-silico molecular doc...