Kathryn E. Lafond, Harish Nair, Mohammad Hafiz Rasooly, Fátima Valente et al.
BACKGROUND: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has be...
Mariafe Calingacion, Alice G. Laborte, Andrew Nelson, Adoracion P. Resurreccion et al.
With the ever-increasing global demand for high quality rice in both local production regions and with Western consumers, we have a strong desire to understand better the importance of the different traits that make up the quality of the rice grain and obtain a full picture of rice quality demograph...
Matthew R. Sydes, Melissa Spears, Malcolm D. Mason, Noel W. Clarke et al.
Background: Adding abiraterone acetate with prednisolone (AAP) or docetaxel with prednisolone (DocP) to standard-of-care (SOC) each improved survival in systemic therapy for advanced or metastatic prostate cancer: evaluation of drug efficacy: a multi-arm multi-stage platform randomised controlled pr...
Qifang Bi, Eva Ferreras, Lorenzo Pezzoli, Dominique Legros et al.
BACKGROUND: Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges...
John Muscedere, Melissa K. Andrew, Sean M. Bagshaw, Carole A. Estabrooks et al.
RÉSUMÉ Avec le vieillissement de la population canadienne, la fragilité – avec son risque accru du déclin fonctionnel, la détérioration de la santé, et le décès – devient de plus en plus répandue. La physiologie de la fragilité reflète son origine parmi organes et systèmes multiples. Environ un quar...
Melissa EK Haines, Francesca E. Hodges, Janet Y. Nale, Jennifer Mahony et al.
Antimicrobial resistance (AMR) is a major problem globally. The main bacterial organisms associated with urinary tract infection (UTI) associated sepsis are E. coli and Klebsiella along with Enterobacter species. These all have AMR strains known as ESBL (Extended Spectrum Beta-Lactamase), which are ...
Gillian Lancaster, Gareth McCray, Patricia Kariger, Tarun Dua et al.
BACKGROUND: Renewed global commitment to the improvement of early child development outcomes, as evidenced by the focus of the United Nations Sustainable Development Goal 4, highlights an increased need for reliable and valid measures to evaluate preventive and interventional efforts designed to aff...
Christine D. Palmer, Ciaran D. Scallan, Lauren D. Kraemer Tardif, Melissa A. Kachura et al.
SARS-CoV-2 has resulted in high levels of morbidity and mortality world-wide, and severe complications can occur in older populations. Humoral immunity induced by authorized vaccines wanes within 6 months, and frequent boosts may only offer transient protection. GRT-R910 is an investigational self-a...
Daniel M. Green, Liang Zhu, Mingjuan Wang, Kirsten K. Ness et al.
RATIONALE: The relationship between treatment-related impairment of pulmonary function in adult survivors of childhood cancer and subsequent physical function has not been studied. OBJECTIVES: In this prospective evaluation of 606 adult survivors of childhood cancer, we sought to determine the risk ...
Junhong Xiao, Aras Bozkurt, Mark Nichols, Angelica Pazurek et al.
Cody T. Ross, Paul L. Hooper, Jennifer E. Smith, Adrian V. Jaeggi et al.
To address claims of human exceptionalism, we determine where humans fit within the greater mammalian distribution of reproductive inequality. We show that humans exhibit lower reproductive skew (i.e., inequality in the number of surviving offspring) among males and smaller sex differences in reprod...
Marjolein J.A. Weerts, Kristina Lanko, Francisco J. Guzmán‐Vega, Adam Jackson et al.
PURPOSE: Pathogenic variants in SETD1B have been associated with a syndromic neurodevelopmental disorder including intellectual disability, language delay, and seizures. To date, clinical features have been described for 11 patients with (likely) pathogenic SETD1B sequence variants. This study aims ...
Paolo Peterlongo, Jenny Chang-Claude, Kirsten B. Moysich, Anja Rudolph et al.
BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In thi...
Rachel L. Byrne, Tom Wingfield, Emily R. Adams, Sayera Banu et al.
Current strategies to promptly, effectively, and equitably screen people with tuberculosis (TB) and link them to diagnosis and care are insufficient; new approaches are required to find the millions of people around the world with TB who are missed each year. Interventions also need to be designed c...
Eric J. Nelson, Ashraful Islam Khan, Adama Mamby Keita, Ben J. Brintz et al.
Importance: Inappropriate use of antibiotics for diarrheal illness can result in adverse effects and increase in antimicrobial resistance. Objective: To determine whether the diarrheal etiology prediction (DEP) algorithm, which uses patient-specific and location-specific features to estimate the pro...