Annemieke Geluk, Kidist Bobosha, Jolien J. van der Ploeg-van Schip, John S. Spencer et al.
Leprosy is not eradicable with currently available diagnostics or interventions, as evidenced by its stable incidence. Early diagnosis of Mycobacterium leprae infection should therefore be emphasized in leprosy research. It remains challenging to develop tests based on immunological biomarkers that ...
Senjuti Kabir, S. M. Mazidur Rahman, Shakil Ahmed, Md Shamiul Islam et al.
BACKGROUND: The World Health Organization recommends the Xpert MTB/RIF Ultra assay for diagnosing pulmonary tuberculosis (PTB) in children. Though stool is a potential alternative to respiratory specimens among children, the diagnostic performance of Xpert Ultra on stool is unknown. Thus, we assesse...
Sayera Banu, Md. Toufiq Rahman, Mohammad Khaja Mafij Uddin, Razia Khatun et al.
BACKGROUND: The objectives of this study were to assess the tuberculosis (TB) burden and to provide an insight into the type of circulating M. tuberculosis species in urban slums of Bangladesh. We also aimed to test the feasibility of a larger transmission study in this setting. METHODS: This cross-...
Sayera Banu, Arman Hossain, Mohammad Khaja Mafij Uddin, Muhammad Reaj Uddin et al.
BACKGROUND: There are limited data on TB among prison inmates in Bangladesh. The aim of the study was to determine the prevalence of pulmonary tuberculosis (TB), its drug resistance and risk factors in Dhaka Central Jail, the largest prison in Bangladesh. METHODS: Cross sectional survey with, active...
Mohammad Khaja Mafij Uddin, Md. Raihan Chowdhury, Shahriar Ahmed, Md. Toufiq Rahman et al.
BACKGROUND: Sputum smear microscopy is fast and inexpensive technique for detecting tuberculosis (TB) in high incidence areas but has low sensitivity. Physical and chemical sputum processing along with centrifugation have been found to show promise in overcoming this limitation. Our objective was to...
Rómulo Aráoz, Nadine Honoré, Sayera Banu, Caroline Demangel et al.
In addition to multidrug therapy, elimination of leprosy requires improved diagnostic methods. Using a comparative genomics approach, 17 potential protein antigens (MLP) that are restricted to Mycobacterium leprae, or of limited distribution, were produced and tested for antigen-specific immune resp...
Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu et al.
ObjectivesTuberculosis (TB) is the leading infectious cause of death in the world. Cheaper and more accessible TB treatment monitoring methods are needed. Here, we evaluated white blood cell (WBC) absolute counts, lymphocyte, and monocyte proportions during TB treatment, and characterized their asso...
Mohammad Khaja Mafij Uddin, Tahmina Shirin, Mohammad Enayet Hossain, Ahmed Nawsher Alam et al.
As the COVID-19 pandemic erupted, the WHO recommended the use of nasopharyngeal or throat swabs for the detection of SARS-CoV-2 etiology of COVID-19. The collection of NPS causes discomfort because of its invasive collection procedure. There are considerable risks to health care workers during the c...
Sayera Banu, Asif Mahmud, Md. Toufiq Rahman, Arman Hossain et al.
BACKGROUND: This study was set out to investigate the magnitude, patterns and molecular characterization of drug-resistant Mycobacterium tuberculosis strains at a tertiary referral hospital in Bangladesh. METHODS: Pulmonary tuberculosis (TB) patients admitted at National Institute of Diseases of the...
Rim Bayaa, Mame Diarra Ndiaye, Carole Chedid, Eka Kokhreidze et al.
There is a crucial need for non-sputum-based TB tests. Here, we evaluate the performance of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment monitoring. RISK6 performance was also compared to that of two IGRAs: one based on RD1 antigens (QuantiFERON-TB Gold Plus,...
Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu et al.
Background Tuberculosis (TB) is a leading infectious cause of death. To improve treatment efficacy, quicker monitoring methods are needed. The objective of this study was to monitor the response to a heparin-binding hemagglutinin (HBHA) interferon- γ (IFN- γ ) release assay (IGRA) and QuantiFERON-TB...
Mohammad Khaja Mafij Uddin, Arfatur Rahman, Md. Fahim Ather, Tanvir Ahmed et al.
Background: Rifampicin resistance (RR) is a key indicator of multidrug-resistant tuberculosis (MDR-TB) and 95% of the RR is associated with the mutation in the 81-bp rifampicin resistance determining region (RRDR) of the rpoB gene of Mycobacterium tuberculosis complex (MTBC). The Xpert MTB/RIF (Xper...
Sayera Banu, Md. Toufiq Rahman, Mohammad Khaja Mafij Uddin, Razia Khatun et al.
BACKGROUND: Understanding tuberculosis (TB) transmission dynamics is essential for establishing effective TB control strategies in settings where the burden and risk of transmission are high. The objectives of this study were to evaluate the effect of active screening on controlling TB transmission ...
Mohammad Riazul Islam, Razia Khatun, Mohammad Khaja Mafij Uddin, Md. Siddiqur Rahman Khan et al.
BACKGROUND: From long instances, it is debatable whether three sputum specimens are required for the diagnosis of pulmonary tuberculosis (TB) or TB can be diagnosed effectively using two consecutive sputum specimens. This study was set out to evaluate the significance of examining multiple sputum sp...
Senjuti Kabir, Mohammad Khaja Mafij Uddin, Mohammod Jobayer Chisti, Tilka Fannana et al.
OBJECTIVE: Better methods are needed for the accurate detection of child tuberculosis (TB). This study compared different laboratory tests and evaluated IS6110 PCR for the detection of Mycobacterium tuberculosis (MTB) among clinically diagnosed child TB patients. METHODS: A total of 102 paediatric p...