Sabeena Ahmed, Mohammad Mahbubul Karim, Allen G. Ross, Mohammad Hossain et al.
Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. A randomized, double-blind, placebo-controlled trial was conducted to determine the rapidity of viral clearance and saf...
Nga Thi Thuy, Huong T L Vu, Chuc T K Nguyen, Sureeporn Punpuing et al.
BACKGROUND: Antimicrobial misuse is common in low-income and middle-income countries (LMICs), and this practice is a driver of antibiotic resistance. We compared community-based antibiotic access and use practices across communities in LMICs to identify contextually specific targets for intervention...
Debasish Saha, Mohammad Mahbubul Karim, Wasif Ali Khan, Sabeena Ahmed et al.
BACKGROUND: Single-dose azithromycin is effective in the treatment of severe cholera in children, but its effectiveness in adults has not been evaluated. METHODS: We conducted a double-blind, randomized trial comparing the equivalence of azithromycin and ciprofloxacin (each given in a single 1-g dos...
M. M. Mahbubul Syeed, Md Shakhawat Hossain, Md. Rajaul Karim, Mohammad Faisal Uddin et al.
Surface water is heavily exposed to contamination as this is the ubiquitous source for most of the water needs. This situation is exaggerated by the excessive population, heavy industrialization, rapid urbanization, and improper sanitation. Comprehensive measurement and knowledge extraction of surfa...
Wasif A. Khan, Kathleen A. Rogers, Mohammad Mahbubul Karim, Sabeena Ahmed et al.
We conducted a prospective case-control study to investigate the epidemiology, clinical features, and systemic antibody responses of cryptosporidiosis in Bangladeshi children. Forty-six children presenting to the International Center for Diarrheal Disease Research, Bangladesh in Dhaka, Bangladesh wi...
Debasish Saha, Wasif Ali Khan, Mohammad Mahbubul Karim, Hafizur Rahman Chowdhury et al.
Background Single-dose ciprofloxacin is effective for the treatment of severe cholera in adults. We assessed whether single-dose ciprofloxacin would be as effective as 3-day, 12-dose erythromycin in achieving clinical cure in children with severe cholera. Methods We did a randomised, open label, con...
Mohammad Abdul Matin, Wasif Ali Khan, Mohammad Mahbubul Karim, Sabeena Ahmed et al.
BACKGROUND: Antibiotic resistance poses a great threat to global health, especially in low- and middle-income countries with a high infectious disease burden and limited resources. In spite of regulations, antibiotics are sold in many settings as non-prescription medicines, resulting in inappropriat...
Genève Allison, Kathleen A. Rogers, Anoli Borad, Sabeena Ahmed et al.
Although Cryptospridium hominis is the dominant Cryptosporidium species infecting humans, immune responses to cognate antigens in C. hominis-infected persons have not been reported. We investigated antibody responses to the immunodominant gp15 antigen from C. hominis and C. parvum, in C. hominis-inf...
Nurun Nahar Rabin, Jannatul Morshed, Hashi Akhter, Md. Saidul Islam et al.
Abstract Surface modification of Zinc oxide nanoparticles (ZnO) with γ-aminopropyltriethoxy silane (APTES) was investigated. Successful surface modification of the nanoparticles was confirmed experimentally by X-ray Photoelectron Spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR)...
David Cheishvili, Chifat Wong, Mohammad Mahbubul Karim, Mohammad Golam Kibria et al.
High-throughput tests for early cancer detection can revolutionize public health and reduce cancer morbidity and mortality. Here we show a DNA methylation signature for hepatocellular carcinoma (HCC) detection in liquid biopsies, distinct from normal tissues and blood profiles. We developed a classi...
Anoli Borad, Genève Allison, David Wang, Sabeena Ahmed et al.
Cryptosporidium is a major cause of diarrhea in children in developing countries. However, there is no vaccine available and little is known about immune responses to protective antigens. We investigated antibody responses to p23, a putative vaccine candidate, in children in Bangladesh with cryptosp...
Kirthi G. Hira, Melanie Mackay, Andrew D. Hempstead, Sabeena Ahmed et al.
The genetic diversity of Cryptosporidium spp. from infected children was characterized for the first time in Bangladesh. Seven C. hominis and C. parvum subtype families (including a new family, IIm) and 15 subtypes (including 2 new subtypes) were identified. The dominance of specific families and su...
Zulkar Nain, Shital K. Barman, Md. Moinuddin Sheam, Shifath Bin Syed et al.
Despite the association of prevalent health conditions with coronavirus disease 2019 (COVID-19) severity, the disease-modifying biomolecules and their pathogenetic mechanisms remain unclear. This study aimed to understand the influences of COVID-19 on different comorbidities and vice versa through n...
Mohammad Shafiqul Islam, Mohammad Mahbubul Karim, Ummul Alam, Khadiza Yesmin
Background:Diabetes distress is a condition distinct from depression that is related to diabetes outcomes.This study intends to identify the predicting risk factors of diabetes distress in Bangladeshi type 2 diabetes mellitus patients. Methods:A cross sectional study was conducted from January to Ju...
Md. Rajaul Karim, M. M. Mahbubul Syeed, Ashifur Rahman, Khondkar Ayaz Rabbani et al.
Assessment and monitoring of surface water quality are essential for food security, public health, and ecosystem protection. Although water quality monitoring is a known phenomenon, little effort has been made to offer a comprehensive and harmonized dataset for surface water at the global scale. Thi...