Yogesh Hooda, Mohammad Saiful Islam Sajib, Hafizur Rahman, Stephen P. Luby et al.
BACKGROUND: With the rise in fluoroquinolone-resistant Salmonella Typhi and the recent emergence of ceftriaxone resistance, azithromycin is one of the last oral drugs available against typhoid for which resistance is uncommon. Its increasing use, specifically in light of the ongoing outbreak of exte...
Megan E. Carey, Zoe A. Dyson, Danielle J. Ingle, Afreenish Amir et al.
Background: serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000). Methods: This is a meta-analysis of global genotype and anti...
Késia Esther da Silva, Arif Mohammad Tanmoy, Agila Kumari Pragasam, Junaid Iqbal et al.
BACKGROUND: The emergence of increasingly antimicrobial-resistant Salmonella enterica serovar Typhi (S Typhi) threatens to undermine effective treatment and control. Understanding where antimicrobial resistance in S Typhi is emerging and spreading is crucial towards formulating effective control str...
Senjuti Saha, Akshaya Ramesh, Katrina Kalantar, Roly Malaker et al.
Globally, there are an estimated 10.6 million cases of meningitis and 288,000 deaths every year, with the vast majority occurring in low- and middle-income countries. In addition, many survivors suffer from long-term neurological sequelae. Most laboratories assay only for common bacterial etiologies...
Mohammad Saiful Islam Sajib, Arif Mohammad Tanmoy, Yogesh Hooda, Hafizur Rahman et al.
In the early 1900s, with mortality of ∼30%, typhoid and paratyphoid (caused by Salmonella Typhi and Paratyphi A) ravaged parts of the world; with improved water, sanitation, and hygiene in resource-rich countries and the advent of antimicrobials, mortality dwindled to <1%. Today, the burden rests...
Arif Mohammad Tanmoy, Emilie Westeel, Katrien De Bruyne, Johan Goris et al.
Typhoid fever, caused by Salmonella enterica serovar Typhi, is responsible for an estimated burden of approximately 17 million new episodes per year worldwide. Adequate and timely antimicrobial treatment invariably cures typhoid fever. The increasing antimicrobial resistance (AMR) of S . Typhi sever...
Kristen Aiemjoy, Jessica C. Seidman, Senjuti Saha, Sira Jam Munira et al.
BACKGROUND: The incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae (Salmonella enterica serovars Typhi and Paratyphi), is largely unknown in regions without blood culture surveillance. The aim of this study was to evaluate whether new diagnostic serological m...
Senjuti Saha, Arif Mohammad Tanmoy, Jason R. Andrews, Mohammad Saiful Islam Sajib et al.
With prequalification of a typhoid conjugate vaccine by the World Health Organization, countries are deciding whether and at what geographic scale to provide the vaccine. Optimal local data to clarify typhoid risk are expensive and often unavailable. To determine whether quantitative polymerase chai...
Senjuti Saha, Arif Mohammad Tanmoy, Yogesh Hooda, Afroza Akter Tanni et al.
After several decades of debate, it is now widely acknowledged that apoptosis, also known as programmed cell death, is central to homoeostasis and normal development and physiology in all multicellular organisms, including humans. The dysregulation of apoptosis can lead to the destruction of normal ...
Senjuti Saha, Md Shfiqul Islam, Mohammad Saiful Islam Sajib, Shampa Saha et al.
BACKGROUND: Typhoid and paratyphoid remain the most common bloodstream infections in many resource-poor settings. The World Health Organization recommends typhoid conjugate vaccines for country-specific introduction, but questions regarding typhoid and paratyphoid epidemiology persist, especially re...
Senjuti Saha, Roly Malaker, Mohammad Saiful Islam Sajib, Md Hasanuzzaman et al.
The complete genome sequence of a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) isolate obtained from a nasopharyngeal swab from a patient with COVID-19 in Bangladesh is reported.
Bilal Djeghout, Senjuti Saha, Mohammad Saiful Islam Sajib, Arif Mohammad Tanmoy et al.
PURPOSE: Ceftriaxone is the drug of choice for typhoid fever and the emergence of resistant Salmonella Typhi raises major concerns for treatment. There are an increasing number of sporadic reports of ceftriaxone-resistant S. Typhi and limiting the risk of treatment failure in the patient and outbrea...
Nazia Khatun, Sajib Ahmed, Mohammad Sajjad Hossain, Syed Farid Uddin Farhad et al.
In the current study, nanocrystalline CoY0.5xLa0.5xFe2-xO4 (where x = 0.00, 0.02, 0.04, 0.06, 0.08, and 0.10) ferrites have been synthesized via a sol-gel auto combustion process. The synthesized powders were pressed into pellet forms and sintered at 900 °C for 4 h in the air. X-ray diffractometry (...
Arif Mohammad Tanmoy, Yogesh Hooda, Mohammad Saiful Islam Sajib, Kesia E. da Silva et al.
Salmonella Paratyphi A, the primary etiology of paratyphoid, is estimated to cause 3.4 million infections annually, worldwide. With rising antimicrobial resistance and no licensed vaccines, genomic surveillance is key to track and monitor transmission, but there is currently no reliable genotyping f...
Yogesh Hooda, Arif Mohammad Tanmoy, Mohammad Saiful Islam Sajib, Senjuti Saha
► Recent studies have shown that mass administration of azithromycin in some areas can lead to reduction in childhood mortality, which in turn has led to additional large-scale trials in many parts of the world.► We provide evidence for the emergence of novel azithromycin resistance mechanisms in co...
Senjuti Saha, Mohammad Saiful Islam Sajib, Denise O. Garrett, Farah Naz Qamar
With the increasing antibacterial resistance in typhoidal Salmonella and the dearth of novel antimicrobials on the horizon, we risk losing our primary defense against widespread morbidity and mortality from enteric fever. During 26-28 March 2019, researchers from around the world came together in Ha...
Arif Mohammad Tanmoy, Chinmoy Saha, Mohammad Saiful Islam Sajib, Senjuti Saha et al.
Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a global health concern and its treatment is problematic due to the rise in antimicrobial resistance (AMR). Rapid detection of patients infected with AMR positive S. Typhi is, therefore, crucial to prevent further spreading. C...
Arif Mohammad Tanmoy, Yogesh Hooda, Mohammad Saiful Islam Sajib, Hafizur Rahman et al.
BACKGROUND: Rising antimicrobial resistance (AMR) in Salmonella Typhi restricts typhoid treatment options, heightening concerns for pan-oral drug-resistant outbreaks. However, lack of long-term temporal surveillance data on AMR in countries with high burden like Bangladesh is scarce. Our study explo...
Senjuti Saha, ASM Nawshad Uddin Ahmed, Probir Kumar Sarkar, Mohammed Rizwanul Ahsan Bipul et al.
BACKGROUND: The impact of SARS-CoV-2 on neonates remains largely unknown in low- and middle-income countries (LMICs). We provide an epidemiologic and clinical report of SARS-CoV-2 infections in neonates hospitalized in Bangladesh. METHODS: Outborn neonates admitted to Dhaka Shishu Hospital, a tertia...
Mohammad Saiful Islam Sajib, Arif Mohammad Tanmoy, Yogesh Hooda, Hafizur Rahman et al.
BACKGROUND: Typhoid and paratyphoid remain common bloodstream infections in areas with suboptimal water and sanitation infrastructure. Paratyphoid, caused by Salmonella Paratyphi A, is less prevalent than typhoid and its antimicrobial resistance (AMR) trends are less documented. Empirical treatment ...