Daniel J. Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah, Mahmoud Abdellatif et al.
autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Katia Koelle, Xavier Rodó, Mercedes Pascual, Mohammad Yunus et al.
Outbreaks of many infectious diseases, including cholera, malaria and dengue, vary over characteristic periods longer than 1 year. Evidence that climate variability drives these interannual cycles has been highly controversial, chiefly because it is difficult to isolate the contribution of environme...
Rita R. Colwell, Anwar Huq, M. Sirajul Islam, K. M. A. Aziz et al.
Based on results of ecological studies demonstrating that Vibrio cholerae, the etiological agent of epidemic cholera, is commensal to zooplankton, notably copepods, a simple filtration procedure was developed whereby zooplankton, most phytoplankton, and particulates >20 microm were removed from wate...
JohnD Clemens, Jeffrey R. Harris, M. R. Khan, BradfordA. Kay et al.
The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Survei...
Mohammad Ali, Michael Emch, Lorenz von Seidlein, Mohammad Yunus et al.
Background Decisions about the use of killed oral cholera vaccines, which confer moderate levels of direct protection to vaccinees, can depend on whether the vaccines also provide indirect (herd) protection when high levels of vaccine coverage are attained. We reanalysed data from a field trial in B...
Guillaume Constantin de Magny, Raghu Murtugudde, Mathew R. P. Sapiano, Azhar Nizam et al.
The causative agent of cholera, Vibrio cholerae , has been shown to be autochthonous to riverine, estuarine, and coastal waters along with its host, the copepod, a significant member of the zooplankton community. Temperature, salinity, rainfall and plankton have proven to be important factors in the...
Anwar Huq, R. Bradley Sack, Azhar Nizam, Ira M. Longini et al.
The occurrence of outbreaks of cholera in Africa in 1970 and in Latin America in 1991, mainly in coastal communities, and the appearance of the new serotype Vibrio cholerae O139 in India and subsequently in Bangladesh have stimulated efforts to understand environmental factors influencing the growth...
Robert E. Black, MichaelH. Merson, Atikur Rahman, Mohammad Yunus et al.
Enteric pathogens associated with diarrhea were studied for two years at a diarrhea treatment center in rural Bangladesh. Enterotoxigenic Escherichia coli (ETEC) was the most frequently identified pathogen for patients of all ages. Rotavirus and ETEC were isolated from approximately 50% and approxim...
Abdullah H Baqui, Robert E. Black, Shams El Arifeen, Mohammad Yunus et al.
Abstract Objective: To evaluate the effect on morbidity and mortality of providing daily zinc for 14 days to children with diarrhoea. Design: Cluster randomised comparison. Setting: Matlab field site of International Center for Diarrhoeal Disease Research, Bangladesh. Participants: 8070 children age...
Roger I. Glass, Jan Holmgren, Charles E. Haley, M. R. Khan et al.
At the Matlab Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh, the authors examined the blood groups of patients hospitalized between January and September 1979 for diarrheal disease due to a variety of bacterial and viral agents. A significant association was identi...
Afruna Rahman, Marie Vahter, Allan H. Smith, Barbro Nermell et al.
The authors evaluated the association of prenatal arsenic exposure with size at birth (birth weight, birth length, head and chest circumferences). This prospective cohort study, based on 1,578 mother-infant pairs, was conducted in Matlab, Bangladesh, in 2002-2003. Arsenic exposure was assessed by an...
Robert E. Black, Kenneth H. Brown, Stan Becker, Mohammad Yunus
Longitudinal studies were done in two villages in rural Bangladesh to learn more about the interactions between infectious diseases and the nutritional status of children. An intensive system of surveillance was used to determine the occurrence and frequency of infectious diseases in a cohort of 197...
Afruna Rahman, Marie Vahter, Eva‐Charlotte Ekström, Md Mijanur Rahman et al.
The authors evaluated the effect of arsenic exposure on fetal and infant survival in a cohort of 29,134 pregnancies identified by the health and demographic surveillance system in Matlab, Bangladesh, in 1991-2000. Arsenic exposure, reflected by drinking water history and analysis of arsenic concentr...
W. Abdullah Brooks, Mohammad Yunus, Mathuram Santosham, MA Wahed et al.
Background Pneumonia is a leading cause of morbidity and mortality in young children. Early reversal of severity signs--chest indrawing, hypoxia, and tachypnoea--improves outcome. We postulated that zinc, an acute phase reactant, would shorten duration of severe pneumonia and time in hospital. Metho...
Rubhana Raqib, Sultan Ahmed, Rokeya Sultana, Yukiko Wagatsuma et al.
Chronic exposure to arsenic, a potent carcinogen and toxicant, via drinking water is a worldwide public health problem. Because little is known about early-life effects of arsenic on immunity, we evaluated the impact of in utero exposure on infant immune parameters and morbidity in a pilot study. Pr...