Maria Argos, Tara Kalra, Paul J. Rathouz, Yu Chen et al.
Background Millions of people worldwide are chronically exposed to arsenic through drinking water, including 35–77 million people in Bangladesh. The association between arsenic exposure and mortality rate has not been prospectively investigated by use of individual-level data. We therefore prospecti...
Yu Chen, J. H. Graziano, F. Parvez, Mengling Liu et al.
OBJECTIVE: To evaluate the association between arsenic exposure and mortality from cardiovascular disease and to assess whether cigarette smoking influences the association. DESIGN: Prospective cohort study with arsenic exposure measured in drinking water from wells and urine. SETTING: General popul...
Brandon L. Pierce, Muhammad G. Kibriya, Tong Lin, Farzana Jasmine et al.
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer. There is inter-individual variation in arsenic metabolism efficiency and susceptibility to arsenic toxicity; however, the basis of this variation ...
Yu Chen, Fen Wu, Mengling Liu, Faruque Parvez et al.
BACKGROUND: Few prospective studies have evaluated the influence of arsenic methylation capacity on cardiovascular disease (CVD) risk. OBJECTIVE: We evaluated the association of arsenic exposure from drinking water and arsenic methylation capacity with CVD risk. METHOD: We conducted a case-cohort st...
Brandon L. Pierce, Tong Lin, Lin Chen, Ronald Rahaman et al.
A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for human disease. Less is known regarding the effects of genetic variation on expression of distant genes (trans-eQT...
Brandon L. Pierce, Tong Lin, Maria Argos, Kathryn Demanelis et al.
Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL (cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral...
Rick J. Jansen, Maria Argos, Tong Lin, Jiabei Li et al.
BACKGROUND: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine ...
Maria Argos, Lin Chen, Farzana Jasmine, Tong Lin et al.
BACKGROUND: Inorganic arsenic is one of the most common naturally occurring contaminants found in the environment. Arsenic is associated with a number of health outcomes, with epigenetic modification suggested as a potential mechanism of toxicity. OBJECTIVE: Among a sample of 400 adult participants,...
Fen Wu, Yu Chen, Faruque Parvez, Stephanie Segers et al.
BACKGROUND: Limited data are available on smoking-related mortality in low-income countries, where both chronic disease burden and prevalence of smoking are increasing. METHODS: Using data on 20,033 individuals in the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh, we prospective...
Maria Argos, Muhammad G. Kibriya, Faruque Parvez, Farzana Jasmine et al.
Millions of individuals worldwide are chronically exposed to arsenic through their drinking water. In this study, the effect of arsenic exposure and arsenical skin lesion status on genome-wide gene expression patterns was evaluated using RNA from peripheral blood lymphocytes of individuals selected ...
Muhammad G. Kibriya, Maruf Raza, Farzana Jasmine, Shantanu Roy et al.
BACKGROUND: We performed a genome-wide scan of 27,578 CpG loci covering 14,475 genes to identify differentially methylated loci (DML) in colorectal carcinoma (CRC). METHODS: We used Illumina's Infinium methylation assay in paired DNA samples extracted from 24 fresh frozen CRC tissues and their corre...
Kathryn Demanelis, Maria Argos, Tong Lin, Justin Shinkle et al.
BACKGROUND: Arsenic exposure affects [Formula: see text] people worldwide, including [Formula: see text] in Bangladesh. Arsenic exposure increases the risk of cancer and other chronic diseases, and one potential mechanism of arsenic toxicity is epigenetic dysregulation. OBJECTIVE: We assessed associ...
Jieying Jiang, Mengling Liu, Faruque Parvez, Binhuan Wang et al.
BackgroundCross-sectional studies have shown associations between arsenic exposure and prevalence of high blood pressure; however, studies examining the relationship of arsenic exposure with longitudinal changes in blood pressure are lacking.MethodWe evaluated associations of arsenic exposure in rel...
Maria Argos, Faruque Parvez, Mahfuzar Rahman, Muhammad Rakibuz‐Zaman et al.
BACKGROUND: Chronic arsenic exposure through drinking water is a public health problem affecting millions of people worldwide, including at least 30 million in Bangladesh. We prospectively investigated the associations of arsenic exposure and arsenical skin lesion status with lung disease mortality ...
Brandon L. Pierce, Tara Kalra, Maria Argos, F. Parvez et al.
BACKGROUND: Body mass index (BMI) (kg/m(2)) has a U- or J-shaped relationship with all-cause mortality in Western and East Asian populations. However, this relationship is not well characterized in Bangladesh, where the BMI distribution is shifted towards lower values. METHODS: Using data on 11,445 ...
Dayana A. Delgado, Chenan Zhang, Lin Chen, Jianjun Gao et al.
Background Leucocyte telomere length (TL) is a potential biomarker of ageing and risk for age-related disease. Leucocyte TL is heritable and shows substantial differences by race/ethnicity. Recent genome-wide association studies (GWAS) report ~10 loci harbouring SNPs associated with leucocyte TL, bu...
Jianjun Gao, Shantanu Roy, Tong Lin, Maria Argos et al.
Background Inorganic arsenic is a carcinogen whose mode of action may involve telomere dysfunction. Recent epidemiological studies suggest that chronic arsenic exposure is associated with longer telomeres and altered expression of telomere-related genes in peripheral blood. In this study, we evaluat...
Maria Argos, Mahfuzar Rahman, Faruque Parvez, James J. Dignam et al.
BACKGROUND: Epidemiologic research suggests that increased cancer risk due to chronic arsenic exposure persists for several decades even after the exposure has terminated. Observational studies suggest that antioxidants exert a protective effect on arsenical skin lesions and cancers among those chro...
Yu Chen, Tyler R. McClintock, Stephanie Segers, Faruque Parvez et al.
Background Dietary pattern analysis is emerging as a practical, effective tool for relating comprehensive dietary intake to risk of cardiovascular disease mortality. However, no studies have applied this technique to a population outside of the developed world. Methods We conducted prospective cohor...
Fen Wu, Farzana Jasmine, Muhammad G. Kibriya, Mengling Liu et al.
Background: Epidemiologic data on genetic susceptibility to cardiovascular effects of arsenic exposure from drinking water are limited.Objective: We investigated whether the association between well-water arsenic and cardiovascular disease (CVD) differed by 170 single nucleotide polymorphisms (SNPs)...