Nicholas Fancourt, Maria Deloria Knoll, Breanna Barger-Kamate, John de Campo et al.
BACKGROUND.: Chest radiographs (CXRs) are a valuable diagnostic tool in epidemiologic studies of pneumonia. The World Health Organization (WHO) methodology for the interpretation of pediatric CXRs has not been evaluated beyond its intended application as an endpoint measure for bacterial vaccine tri...
Alan Tita, Waldemar A. Carlo, Elizabeth M. McClure, Musaku Mwenechanya et al.
BACKGROUND: The use of azithromycin reduces maternal infection in women during unplanned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithromycin would reduce maternal and offspring sepsis or death. METHO...
Daniel E. Park, Henry C. Baggett, Stephen R. C. Howie, Qiyuan Shi et al.
BACKGROUND.: There is limited information on the association between colonization density of upper respiratory tract colonizers and pathogen-specific pneumonia. We assessed this association for Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii. METHODS....
Jennifer Hemingway‐Foday, Alan Tita, Elwyn Chomba, Musaku Mwenechanya et al.
INTRODUCTION: Maternal and neonatal infections are among the most frequent causes of maternal and neonatal mortality, and current antibiotic strategies have been ineffective in preventing many of these deaths. A randomised clinical trial conducted in a single site in The Gambia showed that treatment...
Waldemar A. Carlo, Alan Tita, Janet Moore, Musaku Mwenechanya et al.
BACKGROUND: In 2023, the Azithromycin Prevention in Labor Use (A-PLUS) trial showed intrapartum azithromycin reduces maternal sepsis or death in women with planned vaginal delivery in low-resource settings, but whether it reduces maternal infection is unknown. We aimed to evaluate the effectiveness ...
Sarah Saleem, Haleema Yasmin, Janet Moore, Anum Rahim et al.
OBJECTIVE: To describe the intrapartum and postpartum use of non-study antibiotics in low- and middle-income countries (LMICs) during the double-blinded NICHD Global Network Azithromycin in Labor (A-PLUS) trial. DESIGN: The antibiotic use sub-study was a planned prospective, observational sub-study ...
Robert L. Goldenberg, Sarah Saleem, Sk Masum Billah, Jean Kim et al.
OBJECTIVES: To determine COVID-19 antibody positivity rates over time and relationships to pregnancy outcomes in low- and middle-income countries (LMICs). DESIGN: With COVID-19 antibody positivity at delivery as the exposure, we performed a prospective, observational cohort study in seven LMICs duri...
Richard J. Derman, Shivaprasad S. Goudar, Mrityunjay Metgud, Avinash Kavi et al.
Jackie K. Patterson, Simon Neuwahl, Sydney Kirsch, Janet Moore et al.
BACKGROUND: Sepsis is one of the leading causes of maternal mortality globally. In 2023, the Azithromycin Prevention in Labor Use (A-PLUS) trial showed intrapartum azithromycin for women planning a vaginal birth reduced the risk of maternal sepsis or death and infection. We aimed to evaluate the cos...
Avinash Kavi, Shivaprasad S. Goudar, Manjunath S. Somannavar, Janet Moore et al.
OBJECTIVE: To determine the relation of COVID-19 symptoms to COVID-19 antibody positivity among unvaccinated pregnant women in low- and middle-income countries (LMIC). DESIGN: COVID-19 infection status measured by antibody positivity at delivery was compared with the symptoms of COVID-19 in the curr...
Seemab Naqvi, Sarah Saleem, Sk Masum Billah, Janet Moore et al.
With the paucity of data available regarding COVID-19 in pregnancy in low- and middle-income countries (LMICs), near the start of the pandemic, the Global Network for Women's and Children's Health Research, funded by the National Institute of Child Health and Human Development (NICHD), initiated fou...
Haleema Yasmin, Saba Tanveer, Shiyam Sunder Tikmani, Janet Moore et al.
OBJECTIVES: Antibiotic use is increasing in low- and middle-income countries (LMIC); however, few studies have examined the rates of use in a population. The use of antibiotics for liveborn infants in LMIC was examined. DESIGN: The study, a planned prospective, observational secondary analysis of th...
Larissa Kamgue Sidze, Janet L. Moore, Waldemar A. Carlo, Musaku Mwenechanya et al.
OBJECTIVE: A single oral dose of azithromycin (AZM) given during labor to women planning a vaginal delivery reduced maternal infections including sepsis, with a stronger effect in sub-Saharan Africa than South Asia. Since maternal infection contributes to labor dysfunction and postpartum hemorrhage ...
Elizabeth M. McClure, Alan T N Tita, Waldemar A. Carlo, Sarah Saleem et al.
OBJECTIVE: The randomized trial of azithromycin to reduce maternal and neonatal sepsis (the A-PLUS Trial) found substantial reduction in maternal sepsis among women receiving azithromycin and substantial non-study antibiotic use. This secondary analysis explored the effect modification of non-study ...
Rupsa C. Boelig, Avinash Kavi, Janet Moore, Denise C. Babineau et al.
OBJECTIVE: A multi-centre international trial (A-PLUS), demonstrated that a single dose of 2 g oral azithromycin in labour reduced the risk of maternal sepsis or death, but not neonatal mortality. We aimed to determine whether the efficacy of azithromycin in prevention of any maternal infection or n...