Allan W. Taylor, Dianna M. Blau, Quique Bassat, Dickens Onyango et al.
BACKGROUND: Sub-Saharan Africa and south Asia contributed 81% of 5·9 million under-5 deaths and 77% of 2·6 million stillbirths worldwide in 2015. Vital registration and verbal autopsy data are mainstays for the estimation of leading causes of death, but both are non-specific and focus on a single un...
Natalia Rakislova, Fabíola Fernandes, Lucília Lovane, Luisa Jamisse et al.
BACKGROUND: Minimally invasive tissue sampling (MITS) is a simplified postmortem examination technique that has shown to be an adequate approach for cause of death investigation in low-resource settings. It requires relatively low level of infrastructures and can be performed by health professionals...
Dianna M. Blau, Vicky L. Baillie, Toyah Els, Sana Mahtab et al.
BACKGROUND: Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in ch...
Zachary J. Madewell, Adama Mamby Keita, Priya Gupta, Ashka Mehta et al.
Introduction Malnutrition contributes to 45% of all childhood deaths globally, but these modelled estimates lack direct measurements in countries with high malnutrition and under-5 mortality rates. We investigated malnutrition’s role in infant and child deaths in the Child Health and Mortality Preve...
Sana Mahtab, Zachary J. Madewell, Shabir A. Madhi, Amy Wise et al.
Abstract Background Invasive Group B Streptococcus (GBS) is a common cause of early-onset neonatal sepsis and is also associated with stillbirth. This study aimed to determine the proportion of stillborn infants and infants who died between 0 and 90 days attributable to GBS using postmortem minimall...
Haleluya Leulseged, Christine Bethencourt, Kitiezo Aggrey Igunza, Victor Akelo et al.
INTRODUCTION: Determining aetiology of severe illness can be difficult, especially in settings with limited diagnostic resources, yet critical for providing life-saving care. Our objective was to describe the accuracy of antemortem clinical diagnoses in young children in high-mortality settings, com...
Vicky L. Baillie, Ziyaad Dangor, Dianna M. Blau, Sana Mahtab et al.
Background: Endemic human coronaviruses (HCoV-229E, HKU1, NL63, and OC43) are common causes of mild or asymptomatic respiratory infections in children but are considered rare causes of death. Methods: We evaluated pediatric deaths from January 2017 through December 2022. A panel of experts determine...
Vicky L. Baillie, Ziyaad Dangor, Dianna M. Blau, Sana Mahtab et al.