Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu et al.
ObjectivesTuberculosis (TB) is the leading infectious cause of death in the world. Cheaper and more accessible TB treatment monitoring methods are needed. Here, we evaluated white blood cell (WBC) absolute counts, lymphocyte, and monocyte proportions during TB treatment, and characterized their asso...
Rim Bayaa, Mame Diarra Ndiaye, Carole Chedid, Eka Kokhreidze et al.
There is a crucial need for non-sputum-based TB tests. Here, we evaluate the performance of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment monitoring. RISK6 performance was also compared to that of two IGRAs: one based on RD1 antigens (QuantiFERON-TB Gold Plus,...
Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu et al.
Background Tuberculosis (TB) is a leading infectious cause of death. To improve treatment efficacy, quicker monitoring methods are needed. The objective of this study was to monitor the response to a heparin-binding hemagglutinin (HBHA) interferon- γ (IFN- γ ) release assay (IGRA) and QuantiFERON-TB...
Carole Chedid, Thibault Andrieu, Eka Kokhreidze, Nestani Tukvadze et al.
Tuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematically assess. We hypothesized that microbiological o...
Cécile Chauvel, Philippe Vanhems, Marie-Charlotte Quemin, Marianne Abifadel et al.
INTRODUCTION: The Global Approach to Biology Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL) network is an international scientific network of 21 centres coordinated by the Merieux Foundation (Lyon, France). Mapping and characterising the similarities and differences in...
Carole Chedid, Thibault Andrieu, Eka Kokhreidze, Nestani Tukvadze et al.
Abstract Tuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematically assess. We hypothesized that microbio...