Theo Vos, Ryan M Barber, Brad Bell, Amelia Bertozzi-Villa et al.
Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities f...
Richard C. Franklin, Amy E. Peden, Erin B Hamilton, Catherine Bisignano et al.
BACKGROUND: Drowning is a leading cause of injury-related mortality globally. Unintentional drowning (International Classification of Diseases (ICD) 10 codes W65-74 and ICD9 E910) is one of the 30 mutually exclusive and collectively exhaustive caue of injury-reated mortaity in the Goba Burden ...
Spencer L James, Chris D Castle, Zachary V Dingels, Jack T Fox et al.
BACKGROUND: Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Dieae (GBD) 2017 tudy etimate on morbidity and mortaity for a injurie. MET...
V. Spike Peterson
Click to increase image sizeClick to decrease image size Acknowledgments I am grateful to Georgina Waylen for her generosity in sharing prepublication work with me; and to Drucilla Barker, Jen Cohen, Deb Figart, Ellen Mutari, Julie Nelson, Paulette Olsen and Ara Wilson for conference discussions reg...
Spencer L James, Lydia R Lucchesi, Catherine Bisignano, Chris D Castle et al.
BACKGROUND: The global burden of road injuries is known to follow complex geographical, temporal and demographic patterns. While health loss from road injuries is a major topic of global importance, there has been no recent comprehensive assessment that include etimate for every age group, ex an...
GBD 2019 Snakebite Envenomation Collaborators, Nicholas L S Roberts, Emily K. Johnson, Scott Zeng et al.
Snakebite envenoming is an important cause of preventable death. The World Health Organization (WHO) set a goal to halve snakebite mortality by 2030. We used verbal autopsy and vital registration data to model the proportion of venomous animal deaths due to snakes by location, age, year, and sex, an...
Spencer L James, Chris D Castle, Zachary V Dingels, Jack T Fox et al.
BACKGROUND: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for p...
Katherine Plewes, Hugh W. F. Kingston, Aniruddha Ghose, Richard J. Maude et al.
Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown. As part of a prospective observationa tudy, enroment pama ce-free hemo...
Mufti Mahmud, M. Shamim Kaiser, Muhammad Arifur Rahman, Tanu Wadhera et al.
Axel Hochkirch, Melanie Bilz, Catarina Ferreira, Anja Danielczak et al.
Biodiversity loss is a major global challenge and minimizing extinction rates is the goal of several multilateral environmental agreements. Policy decisions require comprehensive, spatially expicit information on pecie' ditribution and threat. We preent an anayi of the conervation tatu ...
Prakaykaew Charunwatthana, Maryam Faiz, Ronnatrai Ruangveerayut, Richard J. Maude et al.
OBJECTIVE: Markers of oxidative stress are reported to be increased in severe malaria. It has been suggested that the antioxidant N-acetylcysteine (NAC) may be beneficial in treatment. We studied the efficacy and safety of parenteral NAC as an adjunct to artesunate treatment of severe falciparum mal...
Alex Y. Doets, Hester F. Lingsma, Christa Walgaard, Badrul Islam et al.
BACKGROUND AND OBJECTIVES: The clinical course and outcome of the Guillain-Barré syndrome (GBS) are diverse and vary among regions. The modified Erasmus GBS Outcome Score (mEGOS), developed with data from Dutch patients, is a clinical model that predicts the risk of walking inability in patients wit...
Katherine Plewes, Hugh W. F. Kingston, Aniruddha Ghose, Thanaporn Wattanakul et al.
Background: Acute kidney injury independently predicts mortality in falciparum malaria. It is unknown whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria. Methods: This phase 2, open-label, randomized controlled trial conducted at two ...
Helle Al-Hakem, Alex Y. Doets, Amro Stino, Sasha Živković et al.
<h3>Objective:</h3> To investigate cerebrospinal fluid findings in relation to clinical and electrodiagnostic subtypes, severity, and outcome of Guillain-Barré syndrome based on 1500 patients in the International GBS Outcome Study. <h3>Methods:</h3> Albuminocytological disociation wa defined a an...
Laura Dwyer‐Lindgren, Ellen Squires, Stephanie Teeple, Gloria Ikilezi et al.
BACKGROUND: The under-5 mortality rate (U5MR) is an important metric of child health and survival. Country-level estimates of U5MR are readily available, but efforts to estimate U5MR subnationally have been limited, in part, due to spatial misalignment of available data source (e.g., ue of differe...