Sudhin Thayyil, Stuti Pant, Paolo Montaldo, Deepika Shukla et al.
BACKGROUND: Although therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy in low-income and middle-income countries is unclear. We aimed to examine whether therapeutic hypothermia alongside optimal supportive intensive ca...
for the HELIX Trial group, Sudhin Thayyil, Vânia Oliveira, Peter Lally et al.
BACKGROUND: Therapeutic hypothermia reduces death and disability after moderate or severe neonatal encephalopathy in high-income countries and is used as standard therapy in these settings. However, the safety and efficacy of cooling therapy in low- and middle-income countries (LMICs), where 99% of ...
Sudhin Thayyil, Paolo Montaldo, Vaisakh Krishnan, Phoebe Ivain et al.
Importance: The association between place of birth and hypothermic neuroprotection after hypoxic-ischemic encephalopathy (HIE) in low- and middle-income countries (LMICs) is unknown. Objective: To ascertain the association between place of birth and the efficacy of whole-body hypothermia for protect...
Paolo Montaldo, Constance Burgod, Jethro Herberg, Myrsini Kaforou et al.
Importance: Induced hypothermia, the standard treatment for hypoxic-ischemic encephalopathy (HIE) in high-income countries (HICs), is less effective in the low-income populations in South Asia, who have the highest disease burden. Objective: To investigate the differences in blood genome expression ...
Paolo Montaldo, Aubrey J. Cunnington, Vânia Oliveira, Ravi Swamy et al.
A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome may accelerate the development of neuroprotectants. We examined if a whole blood transcriptomic signature measured soon after birth, predicts adverse neurodevelopmental outcome eighteen months after n...
Constance Burgod, Munirah Mazlan, Stuti Pant, Vaisakh Krishnan et al.
Background: Effect of duration of birth depression on neurodevelopmental outcomes in low- and middle-income countries (LMICs) is not known. We examined the association of birth depression with brain injury, neurodevelopmental outcomes, and hypothermia after hypoxic ischemic encephalopathy (HIE) in s...
Reema Garegrat, Atul Londhe, Swati Manerkar, Sudhindrashayana Fattepur et al.
OBJECTIVE: To examine the feasibility of early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy (HIE). DESIGN: Double-blind pilot randomised controlled trial. SETTING: Eight neonatal units in South Asia. PATIENTS: Neonates (≥36 weeks) with moderate or severe HIE admitte...