Michael J. Barratt, Sharika Nuzhat, Kazi Ahsan, Steven A. Frese et al.
Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. Bifidobacterium longum subspecies infantis is a prominent early colonizer of the infant gut that consumes human milk oligosaccharides (HMOs). We found that the absolute abundance of Bifidobacterium infanti...
Sharika Nuzhat, S. M. Tafsir Hasan, Parag Palit, Md Ridwan Islam et al.
Severe acute malnutrition (SAM) is a major global public health problem. We aimed to assess the effects of probiotic and synbiotic supplementation on rate of weight gain and change in length in young SAM infants. This study was substudy of a single-blind randomized clinical trial (NCT0366657). Durin...
Sharika Nuzhat, Rina Das, Subhasish Das, Shoeb Bin Islam et al.
Antimicrobial resistance against shigellosis is increasingly alarming. However, evidence-based knowledge gaps regarding the changing trends of shigellosis in Bangladesh exist due to the scarcity of longitudinal data on antimicrobial resistance. Our study evaluated the last 20 years antimicrobial res...
Rina Das, Parag Palit, Md. Ahshanul Haque, Myron M. Levine et al.
BACKGROUND: Entamoeba histolytica, Giardia, and Cryptosporidium are common intestinal protozoan parasites that contribute to a high burden of childhood morbidity and mortality. Our study quantified the association between intestinal protozoan parasites and child anthropometric outcomes among childre...
Rina Das, Sabiha Nasrin, Parag Palit, Rukaeya Amin Sobi et al.
With more than 100,000 cases estimated each year, Bangladesh is one of the countries with the highest number of people at risk for cholera. Moreover, Bangladesh is formulating a countrywide cholera-control plan to satisfy the GTFCC (The Global Task Force on Cholera Control) Roadmap's goals. With a p...
Rina Das, Parag Palit, Md. Ahshanul Haque, Mustafa Mahfuz et al.
There is a lack of information highlighting the possible association between strain carrying genes of enteroaggregative Escherichia coli (EAEC) and environmental enteric dysfunction (EED) and on linear growth during childhood. Strain carrying genes of EAEC from stool samples collected from 1705 chil...
Md Ridwan Islam, Sharika Nuzhat, Shah Mohammad Fahim, Parag Palit et al.
AIMS: Appropriate rehydration has always been significant in treating diarrhoeal diseases in children. Irrational antibiotic use among diarrhoeal children has remained a major public health concern. Information regarding antibiotic use in young infants suffering from diarrhoea is very limited and a ...
Parag Palit, Rina Das, Md. Ahshanul Haque, Md. Mehedi Hasan et al.
The prevalence of norovirus infections in different geographical locations and their attribution to childhood diarrhea is well established. However, there are no reports showing possible relationships of different norovirus genogroups with subsequent childhood malnutrition. In this study, we attempt...
Farhana Tasnim Chowdhury, Mohammad Umer Sharif Shohan, Tasmia Islam, Taisha T. Mimu et al.
Background: Leishmaniasis is a disease caused by the Leishmania sp. and can be classified into two major types: cutaneous and visceral leismaniasis. Visceral leishmaniasis is the deadlier type and is mediated by Leishmania donovani and involves the establishment of persistent infection and causes da...
Rina Das, Parag Palit, Md. Ahshanul Haque, Tahmeed Ahmed et al.
There is a lack of information highlighting associations between different pathogenic variants of diarrheagenic Escherichia coli and childhood growth. Pathogenic variants of E. coli from stool samples, collected from 22,567 children enrolled in the Global Enteric Multicenter Study from December 2007...
Md. Amran Gazi, Sultan Mahmud, Shah Mohammad Fahim, Mohammad Golam Kibria et al.
Shigella spp. constitutes some of the key pathogens responsible for the global burden of diarrhoeal disease. With over 164 million reported cases per annum, shigellosis accounts for 1.1 million deaths each year. Majority of these cases occur among the children of the developing nations and the emerg...
Sabiha Nasrin, Md. Ahshanul Haque, Parag Palit, Rina Das et al.
Asymptomatic or subclinical infection by diarrheal enteropathogens during childhood has been linked to poor health and nutritional outcomes. In this study, we aimed to assess the impact of asymptomatic Shigella infection on different forms of childhood malnutrition including the composite index of a...
Rina Das, Parag Palit, Md. Ahshanul Haque, Mustafa Mahfuz et al.
There is a lack of information highlighting the possible association between the genomic subtypes of enteropathogenic Escherichia coli (EPEC) on environmental enteric dysfunction (EED) and on linear growth during childhood. Genomic subtypes of EPEC from stool samples collected from 1705 children enr...
Sharika Nuzhat, SM Tafsir Hasan, Parag Palit, Farzana Afroze et al.
Objective To compare the health and nutrition of children younger than 5 years admitted to hospital during and before the coronavirus disease 2019 (COVID-19) pandemic in Bangladesh. Methods We collected data from hospital records of children 0-59 months admitted to the Dhaka Hospital of the Internat...
Md. Ahshanul Haque, Sabiha Nasrin, Parag Palit, Rina Das et al.
Asymptomatic infection by fecal enteropathogens is a major contributor to childhood malnutrition. Here, we investigated the incidence rate of asymptomatic infection by enterotoxigenic Escherichia coli (ETEC) and assessed its association with childhood stunting, wasting, and being underweight among c...
Zannatun Noor, Md. Mehedi Hasan, Md. Amran Gazi, Farzana Hossaini et al.
Malnourished children are susceptible to an increased risk of mortality owing to impaired immune functions. However, the underlying mechanism of altered immune functions and its interaction with malnutrition is poorly understood. This study investigates the immune function and evaluates the effect o...
Md Iqbal Hossain, Sabiha Nasrin, Rina Das, Parag Palit et al.
Campylobacter is a major cause of food-borne gastrointestinal illnesses worldwide, predominantly affecting children under 5 years of age. This study examined potential associations of symptomatic (with diarrhea) and asymptomatic (without diarrhea) Campylobacter infections with child growth among chi...
Sharika Nuzhat, Parag Palit, Mustafa Mahfuz, Md Ridwan Islam et al.
Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and the growth of infants. We aimed to determine the association of different HMOs with severe acute malnutrition (SAM) among Bangladeshi young infants. This study was nested within a single-blind, randomized, pil...
Irin Parvin, Sumon Kumar Das, Shahnawaz Ahmed, Aminur Rahman et al.
Gestational Toxoplasma gondii (T. gondii) infection may cause substantial adverse effects on developing fetuses, newborns and also mothers. This study aims to estimate the seroprevalence of T. gondii among rural Bangladeshi pregnant women and determine the risk of a low birth weight (LBW). We follow...
Parag Palit, Md. Amran Gazi, Subhasish Das, Md. Mehedi Hasan et al.
Dysregulations in the mammalian target of rapamycin (mTOR) pathway are associated with several human anomalies. We aimed to elucidate possible implications for potential aberrations in the mTOR pathway with childhood malnutrition. We analyzed the activity of phospho-mTORC1 and the expressions of sev...