Mohammod Jobayer Chisti, Mohammed Abdus Salam, Jonathan H. Smith, Tahmeed Ahmed et al.
Background In developing countries, mortality in children with very severe pneumonia is high, even with the provision of appropriate antibiotics, standard oxygen therapy, and other supportive care. We assessed whether oxygen therapy delivered by bubble continuous positive airway pressure (CPAP) impr...
Pradip Kumar Bardhan
Helicobacter pylori infection has a worldwide distribution, and it has distinct epidemiological features in developing countries. In contrast to that in developed countries, H. pylori infection in developing countries seems to be nearly universal, beginning in early childhood. Children become infect...
Pradip Kumar Bardhan, Shah M. Faruque, Aliya Naheed, David A. Sack
In 1999, a review of the literature for 1966-1997 suggested that ≈1.1 million persons die annually of shigellosis, including ≈880,000 in Asia. Our recent review of the literature for 1990-2009 indicates that ≈125 million shigellosis cases occur annually in Asia, of which ≈14,000 are fatal. This esti...
Shafiqul Alam Sarker, Bernard Berger, Ying Deng, Silas Kieser et al.
A T4-like coliphage cocktail was given with different oral doses to healthy Bangladeshi children in a placebo-controlled randomized phase I safety trial. Fecal phage detection was oral dose dependent suggesting passive gut transit of coliphages through the gut. No adverse effects of phage applicatio...
Hasan Ashraf, Nur Alam, Christian Rothermundt, Abdullah Brooks et al.
BACKGROUND: Viral hepatitis is a serious global public health problem affecting billions of people globally, and both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are rapidly spreading in the developing countries including Bangladesh due to the lack of health education, poverty, il...
Nur Alam, Rémy Meier, Heinz Schneider, Shafiqul Alam Sarker et al.
BACKGROUND: Partially hydrolyzed guar gum (Benefiber; Novartis Nutrition, Minneapolis, MN, U.S.A.) is fermented by colonic bacteria liberating short-chain fatty acids (SCFAs), which accelerate colonic absorption of salt and water. The purpose of this study was to evaluate the effect of Benefiber (BF...
Pius Hildebrand, Pradip Kumar Bardhan, Livio Rossi, Shahana Parvin et al.
Background & aims In developing countries where Helicobacter pylori infection is widespread, posttherapeutic recurrence rates may be high. Many of the limited studies available have methodological problems and show varied recurrence rates. We determined late recrudescence rates, true reinfection, an...
Mohammod Jobayer Chisti, Stephen M. Graham, Trevor Duke, Tahmeed Ahmed et al.
BACKGROUND: Post-discharge mortality among children with severe illness in resource-limited settings is under-recognized and there are limited data. We evaluated post-discharge mortality in a recently reported cohort of children with severe malnutrition and pneumonia, and identified characteristics ...
Dilip Mahalanabis, M. Masudur Rahman, Shafiqul Alam Sarker, Pradip Kumar Bardhan et al.
BACKGROUND: The gastric acid barrier, an important host defence against small bowel infection, may be compromised by infection with Helicobacter pylori. In developing countries, H. pylori infection occurs early in life and prevalence of hypochlorhydria is high particularly in the malnourished, which...
Leanne Unicomb, NURUN NAHAR BANU, Tasnim Azim, Asma Islam et al.
BACKGROUND: Diarrhea is an important public health concern in developing countries such as Bangladesh. Diarrhea in children that persists for 14 days or more occurs in 7% of patients in Bangladesh and frequently results in death. Astrovirus has been demonstrated as a cause of acute and nosocomial di...
Catherine E. Garner, Stella Smith, Pradip Kumar Bardhan, Norman M. Ratcliffe et al.
The aim of this pilot study was to analyse the volatile organic compounds in faecal samples collected from cholera patients in Bangladesh to determine biomarkers that could be used for disease diagnosis. Samples were collected from patients at the International Centre for Diarrhoeal Disease Research...
Moydul Islam, Abul Kalam Azad, Pradip Kumar Bardhan, Rubhana Raqib et al.
One hundred and thirty-three colonic biopsies of proven cases of Shigella colitis were examined and post-mortem examinations were carried out on 29 fatal cases at the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B) hospital between 1988 and 1992. The distribution of patho...
Shafiqul Alam Sarker, Martin Jäkel, Shamima Sultana, Nur Alam et al.
Background & aims Rotavirus infection is a leading cause of morbidity and mortality in children younger than 5 years of age. Current treatment options are limited. We assessed the efficacy of a llama-derived, heavy-chain antibody fragment called anti-rotavirus protein (ARP1), in modifying the severi...
Jason B. Harris, Regina C. LaRocque, Richelle C. Charles, Ramendra Nath Mazumder et al.
The cholera epidemics of the 19th century forged the way for the sanitation revolution and the provision of safe public water sources that are the hallmark of developed countries. Nevertheless, more than 1 billion people today, including much of the population in Haiti, lack access to improved water...
Rubhana Raqib, Caroline Ekberg, Protim Sharkar, Pradip Kumar Bardhan et al.
Shigella dysenteriae type 1-induced apoptotic cell death in rectal tissues from patients infected with Shigella dysenteriae type 1 was studied by the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) technique and annexin V staining. Expression of proteins and cytok...