Results for “"Prakesh S. Shah"”

Daniel Roth, Alison D. Gernand, Shaun K. Morris, Brendon Pezzack et al.

BACKGROUND: Vitamin D regulates bone mineral metabolism and skeletal development. Some observational studies have suggested that prenatal vitamin D deficiency increases the risk of adverse pregnancy and/or birth outcomes; however, there is scant evidence from controlled trials, leading the World Hea...

Rana Esmaeilizand, Prakesh S. Shah, Mary Seshia, Wendy Yee et al.

OBJECTIVE: To examine the association between the duration of antibiotic exposure and development of stage 2 or 3 necrotizing enterocolitis (NEC) in very preterm neonates. STUDY DESIGN: A retrospective case-control study was conducted from Canadian Neonatal Network data for preterm neonates born bef...

Nandita Perumal, Eric O. Ohuma, Andrew M. Prentice, Prakesh S. Shah et al.

Abstract Background The INTERGROWTH‐21st sex and gestational age (GA) specific newborn size standards (IG‐NS) are intended to complement the World Health Organization Child Growth Standards (WHO‐GS), which are not GA‐specific. We examined the implications of using IG‐NS at birth and WHO‐GS at postna...

Lisa G. Pell, Huma Qamar, Diego G. Bassani, Cole Heasley et al.

ABSTRACT Lactiplantibacillus plantarum ATCC 202195 (LP202195) plus fructooligosaccharide (FOS) for 7 days was previously shown to colonize the infant intestine up to 6 months of age and reduced sepsis rates among young infants in rural India. In a phase 2 randomized controlled trial in Dhaka, Bangla...

Kine Eide Kvitne, Celeste Allaband, Jennifer C. Onuora, Daniela S. Perry et al.

Early life is a critical period for immune and metabolic development, but these patterns remain underexplored in populations from low- and middle-income countries. Here, we profile the microbiome and metabolome of 55 Bangladeshi mother-infant dyads over the first 6 months of life. Importantly, we ob...

Aline C. Freitas, Grace Li, Jakaria Shawon, Huma Qamar et al.

ABSTRACT The early infant gut microbiota is generally dominated by bifidobacteria, but there is substantial variation at the (sub)species level. Patterns of postnatal Bifidobacterium subspecies colonization in low- or middle-income countries have not been widely studied. We used (sub)species-specifi...

Cole Heasley, Veselina Stefanova, Colin Funk, Aline C. Freitas et al.

Abstract B. infantis abundance in the infant gut may be associated with growth and health outcomes. However, these relationships have not been widely studied in settings where B. infantis is a dominant early-life commensal and growth faltering is prevalent. Here, we estimated associations between ne...

Alastair Fung, Cole Heasley, Lisa G. Pell, Diego G. Bassani et al.

Introduction: Heterogeneity in definitions of severe infection, sepsis and serious bacterial infection (SBI) in infants limits the comparability of randomised controlled trials (RCTs) of infection prevention interventions. To inform the design of infection prevention RCTs for infants in low-resource...

Aline C. Freitas, Grace Li, Jakaria Shawon, Huma Qamar et al.

ABSTRACT The early infant gut microbiota is dominated by bifidobacteria, but there is substantial variation at the (sub)species level. Patterns of postnatal Bifidobacterium subspecies colonization in low or middle-income countries have not been widely studied. We used (sub)species-specific qPCR to q...

Leanna Cho, Alison Dasiewicz, Kelly Watson, Huma Qamar et al.

Infant undernutrition, defined by length- and weight-based indices, is common in low- and middle-income countries (LMICs), but corresponding deficits in head size have received less attention. In a cohort of term newborns in Dhaka, Bangladesh, we compared the severity of deficits (vs. World Health O...

Alastair Fung, Cole Heasley, Lisa G. Pell, Diego G. Bassani et al.

ABSTRACT Introduction Heterogeneity in definitions of severe infection, sepsis and serious bacterial infection (SBI) in young infants limits the comparability of randomized controlled trials (RCTs) of infection prevention interventions. To inform the design of severe infection prevention RCTs for yo...

Maimuna Gias, Huma Qamar, Farzana Fariha, Abdullah Al Mahmud et al.

Abstract Objective: Growth faltering is widespread in many low- and middle-income countries, but its effects on childhood bone mass accrual are unknown. The objective of this study was to estimate associations between length (conditional length-for-age z -scores, cLAZ) and weight (conditional weight...

Daniel Roth, Shaun K. Morris, Stanley Zlotkin, Alison D. Gernand et al.

(Abstracted from N Engl J Med 2018;379:535–546) It is unclear whether maternal vitamin D supplementation during pregnancy and lactation improves fetal and infant growth in regions where vitamin D deficiency is common.

Cole Heasley, Veselina Stefanova, Celine Funk, Aline C. Freitas et al.

colonization is unlikely to improve growth in populations with postnatal faltering.

Alastair Fung, Marimuthu Sappani, Cole Heasley, Chun‐Yuan Chen et al.

ABSTRACT Introduction To improve upon the World Health Organization (WHO) 8 danger signs used to identify young infants (<2 months) requiring referral during community health worker (CHW) home visits, aggregative features (e.g., cumulative visits with fever) rather than visit-specific features (e...

Kine Eide Kvitne, Celeste Allaband, Jennifer C. Onuora, Daniela S. Perry et al.

ABSTRACT Early life is a critical period for immune and metabolic programming, but developmental patterns remain underexplored in populations from low- and middle-income countries. Here, we profiled the microbiome and metabolome of 55 Bangladeshi mother-infant dyads over the first six months of life...

Jennifer C. Onuora, Anna Neustaeter, Huma Qamar, Lisa G. Pell et al.

Objectives: Biomarker measurements are subject to intra-individual variation but the implications for prevalence assessment are uncertain.We assessed agreement between repeated biomarker measurements (3-wk interval) and whether adjustment for intra-individual variation influenced prevalence estimate...