Rémi Villenave, Surendran Thavagnanam, Séverine Sarlang, Jeremy C. Parker et al.
Respiratory syncytial virus (RSV) is the major viral cause of severe pulmonary disease in young infants worldwide. However, the mechanisms by which RSV causes disease in humans remain poorly understood. To help bridge this gap, we developed an ex vivo/in vitro model of RSV infection based on well-di...
Rémi Villenave, Dara O’Donoghue, Surendran Thavagnanam, Olivier Touzelet et al.
BACKGROUND: Human respiratory syncytial virus (RSV) causes severe respiratory disease in infants. Airway epithelial cells are the principle targets of RSV infection. However, the mechanisms by which it causes disease are poorly understood. Most RSV pathogenesis data are derived using laboratory-adap...
Rémi Villenave, Lindsay Broadbent, Isobel Douglas, Jeremy Lyons et al.
UNLABELLED: Airway epithelium is the primary target of many respiratory viruses. However, virus induction and antagonism of host responses by human airway epithelium remains poorly understood. To address this, we developed a model of respiratory syncytial virus (RSV) infection based on well-differen...
Rémi Villenave, Olivier Touzelet, Surendran Thavagnanam, Séverine Sarlang et al.
Sendai virus (SeV) is a murine respiratory virus of considerable interest as a gene therapy or vaccine vector, as it is considered nonpathogenic in humans. However, little is known about its interaction with the human respiratory tract. To address this, we developed a model of respiratory virus infe...