Rajnish Kumar, Anju Sharma, Αθανάσιος Αλεξίου, Anwar L. Bilgrami et al.
The blood-brain barrier (BBB) is a selective and semipermeable boundary that maintains homeostasis inside the central nervous system (CNS). The BBB permeability of compounds is an important consideration during CNS-acting drug development and is difficult to formulate in a succinct manner. Clinical ...
Rajnish Kumar, Anju Sharma, Janmejai Kumar Srivastava, Mohammed Haris Siddiqui et al.
The outbreak of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected the entire world with its infectious spread and mortality rate. The severe cases of coronavirus disease 2019 (COVID-19) are characterized by hypoxia and acute respiratory distress syndrome. In the absence...
Jamshed Bomanji, Rajnish Sharma, Bhagwant Rai Mittal, Sanjay Gambhir et al.
Background A large proportion of the huge global burden of extrapulmonary tuberculosis (EPTB) cases are treated empirically without accurate definition of disease sites and extent of multi-organ disease involvement. Positron emission tomography (PET) imaging using 2-deoxy-2-(fluorine-18) fluoro- d -...
Rajnish Kumar, Farhat Ullah Khan, Anju Sharma, Mohammed Haris Siddiqui et al.
We are exposed to various chemical compounds present in the environment, cosmetics, and drugs almost every day. Mutagenicity is a valuable property that plays a significant role in establishing a chemical compound's safety. Exposure and handling of mutagenic chemicals in the environment pose a high ...
Jamshed Bomanji, Rajnish Sharma, Bhagwant Rai Mittal, Sanjay Gambhir et al.
Background Initial studies of tuberculosis (TB) in macaques and humans using 18 F-FDG positron emission tomography (PET) imaging as a research tool suggest its usefulness in localising disease sites and as a clinical biomarker. Sequential serial scans in patients with extrapulmonary TB (EPTB) could ...