Keith P. West, Abu Ahmed Shamim, Sucheta Mehra, Alain Labrique et al.
<h3>Importance</h3> Maternal micronutrient deficiencies may adversely affect fetal and infant health, yet there is insufficient evidence of effects on these outcomes to guide antenatal micronutrient supplementation in South Asia. <h3>Objective</h3> To assess effects of antenatal multiple micronutrie...
Kerry Schulze, Sucheta Mehra, Saijuddin Shaikh, Hasmot Ali et al.
BACKGROUND: Antenatal multiple micronutrient (MM) supplementation improves birth outcomes relative to iron-folic acid (IFA) in developing countries, but limited data exist on its impact on pregnancy micronutrient status. OBJECTIVE: We assessed the efficacy of a daily MM (15 nutrients) compared with ...
Rebecca D. Merrill, Abu Ahmed Shamim, Hasmot Ali, Nusrat Jahan et al.
Women of reproductive age are at a high risk of iron deficiency, often as a result of diets low in bioavailable iron. In some settings, the iron content of domestic groundwater sources is high, yet its contribution to iron intake and status has not been examined. In a rural Bangladeshi population of...
Rebecca D. Merrill, Abu Ahmed Shamim, Hasmot Ali, Alain Labrique et al.
Iron deficiency was absent in a recent population assessment of rural Bangladeshi women exhibiting anemia (57%), suggesting other causes of low hemoglobin. We assessed the relative influence on anemia of thalassemia, groundwater arsenic and iron, and diet among women of reproductive age living in ru...
Yunhee Kang, Víctor M. Aguayo, Rebecca K. Campbell, Keith P. West
Stunting (length-for-age z score < -2) before 2 years of age has shown associations with poor child developmental indicators, but information at the population level is scarce in South Asia, the region with the highest burden of stunting. We examined associations between z scores (i.e., height for a...
Abu Ahmed Shamim, Kerry Schulze, Rebecca D. Merrill, Alamgir Kabir et al.
Background Tocopherols were discovered for their role in animal reproduction, but little is known about the contribution of deficiencies of vitamin E to human pregnancy loss. Objective We sought to determine whether higher first-trimester concentrations of α-tocopherol and γ-tocopherol were associat...
Rebecca K. Campbell, Kerry Schulze, Saijuddin Shaikh, Sucheta Mehra et al.
OBJECTIVES: Environmental enteric dysfunction (EED) may inhibit growth and development in low- and middle-income countries, but available assessment methodologies limit its study. In rural Bangladesh, we measured EED using the widely used lactulose mannitol ratio (L:M) test and a panel of intestinal...
Avrom S. Caplan, Gabrielle C. Todd, YanChun Zhu, Michelle Sikora et al.
Importance: Trichophyton indotineae is an emerging dermatophyte causing outbreaks of extensive tinea infections often unresponsive to terbinafine. This species has been detected worldwide and in multiple US states, yet detailed US data on infections with T indotineae are sparse and could improve tre...
Daniel Carney, Nirmal Raj, Y. Bai, J. Berger et al.
We outline the unique opportunities and challenges in the search for “ultraheavy” dark matter candidates with masses between roughly 10 TeV and the Planck scale m_{\rm pl} ≈ 10^{16} TeV. This mass range presents a wide and relatively unexplored dark matter parameter space, with a rich space of possi...
Joanne Trigwell, Rebecca Murphy, N. Timothy Cable, Gareth Stratton et al.
Guidelines recommend children and young people participate in at least 60 min of physical activity (PA) every day, however, findings from UK studies show PA levels of children vary across ethnic groups. Since parents play an instrumental role in determining children’s PA levels, this article aims to...
Rebecca K. Campbell, Kristen M. Hurley, Abu Ahmed Shamim, Saijuddin Shaikh et al.
BACKGROUND: Complementary food supplements (CFSs) can enhance growth where stunting is common, but substitution for the usual diet may reduce observed benefits. OBJECTIVE: We aimed to characterize dietary diversity from home foods in a CFS efficacy trial and determine whether supplementation reduced...
Yunhee Kang, Víctor M. Aguayo, Rebecca K. Campbell, Laigden Dzed et al.
Childhood malnutrition remains endemic in South Asia, although the burden varies by country. We examined the anthropometric status and risk factors for malnutrition among children aged 0-59 months through the 2015 National Nutrition Survey in Bhutan. We assessed in 1,506 children nutritional status ...
A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, J.D. Osko et al.
Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-selective inhibitors based on the X-ray crystal studies of the hit 6a. ...
Abu Ahmed Shamim, Alamgir Kabir, Rebecca D. Merrill, Hasmot Ali et al.
OBJECTIVE: The objective of the current analysis was to explore the association of multiple micronutrients with Hb concentration among pregnant women in a South Asian setting, a topic that has not been adequately explored. DESIGN: Sociodemographic, anthropometric and micronutrient status (plasma fer...
Christopher D. Heaney, Brittany Kmush, Ana Navas‐Acién, Kevin A. Francesconi et al.
Background Arsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans. Objectives We aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E virus (HEV) infection, defined as seroconversion during p...