Kathryn Thomson, Calie Dyer, Feiyan Liu, Kirsty Sands et al.
BACKGROUND: Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicr...
Muhammad Umair, Brekhna Hassan, Refath Farzana, Qasim Ali et al.
BACKGROUND: The emergence of colistin-resistant Enterobacterales is a global public health concern, yet colistin is still widely used in animals that are used for food as treatment, metaphylaxis, prophylaxis, and growth promotion. Herein, we investigate the effect of colistin-resistant Enterobactera...
Refath Farzana, Lim Jones, Md. Anisur Rahman, Diego O. Andrey et al.
We report a clonal outbreak of multidrug-resistant (MDR) Klebsiella variicola (sequence type [ST] 771) in a Bangladeshi neonatal unit from October 2016 to January 2017, associated with high mortality (54.5%). During the outbreak, K. variicola ST771 acquired an MDR plasmid harboring blaNDM-1, linked ...
Refath Farzana, Lim Jones, Andrew H. Barratt, Muhammad Anisur Rahman et al.
There is a marked paucity in our understanding of the epidemiology of colistin-resistant bacterial pathogens in South Asia. A report by Davies and Walsh (Lancet Infect Dis 18:256–257, https://doi.org/10.1016/S1473-3099(18)30072-0 , 2018) suggests the export of colistin from China to India, Vietnam, ...
Refath Farzana, SM Shamsuzzaman, Kazi Zulfiquer Mamun
INTRODUCTION: New Delhi metallo-beta-lactamse-1 (NDM-1) producing superbugs create a global public health problem because of their resistance to most antibiotics. This study was conducted to determine the presence of MBL producers, including NDM-1 producers, in Bangladesh, along with the antimicrobi...
Refath Farzana, Lim Jones, Md. Anisur Rahman, Kirsty Sands et al.
SUMMARY: 10.6% patients were CRE positive. Only 27% patients were prescribed at least 1 antibiotic to which infecting pathogen was susceptible. Burn and ICU admission and antibiotics exposures facilitate CRE acquisition. Escherichia coli ST167 was the dominant CRE clone. BACKGROUND: Given the high p...
Refath Farzana, SM Shamsuzzaman, Kazi Zulfiquer Mamun, P. Shears
From a total of 320 bacterial samples from wound swab and urine 169 (53%) gram-negative bacteria were isolated, of which 42 (25%) extended-spectrum beta-lactamase (ESBL) producers were detected by double-disk synergy test. ESBL producers were significantly more resistant against amoxiclav, Co-trimox...
Refath Farzana, Göte Swedberg, Christian G. Giske, Badrul Hasan
Carbapenemase-producing multidrug-resistant (MDR) Acinetobacter baumannii is a global health care problem. MDR A. baumannii has emerged as an important nosocomial pathogen, costing many lives worldwide including Bangladesh. To investigate the detailed molecular epidemiology of carbapenem-resistant A...
Nazma Khatun, Refath Farzana, Bruno S. Lopes, SM Shamsuzzaman
This study was designed to investigate the resistance profile along with the genetic background of resistance to beta-lactam antibiotics among the nosocomial A. baumannii in Bangladesh. A. baumannii was confirmed by detecting blaoXA-51-like. Antibiotic susceptibility was determined by disk diffusion...
Refath Farzana, Lim Jones, Md. Anisur Rahman, Mark A. Toleman et al.
INTRODUCTION: The emergence of plasmid mediated mcr in bacteria has become global public health threat. Herein, we report a mcr-1 positive E. coli in normal human flora from a patient admitted in Dhaka Medical College Hospital (DMCH). METHODOLOGY: In total, 700 non-duplicate rectal swabs were collec...
Refath Farzana, Lim Jones, Md. Anisur Rahman, Kirsty Sands et al.
BACKGROUND: Burkholderia cepacia complex (Bcc) is a group of serious pathogens in cystic fibrosis patients and causes life threatening infections in immunocompromised patients. Species within the Bcc are widely distributed within the environment, can survive in the presence of disinfectants and anti...
Refath Farzana, Stephan Jürgen Harbarth, Ly‐Mee Yu, Edoardo Carretto et al.
Background: This study aimed to evaluate the trends in antimicrobial prescription during the first 1.5 years of COVID-19 pandemic. Methods: This was an observational, retrospective cohort study using patient-level data from Bangladesh, Brazil, India, Italy, Malawi, Nigeria, South Korea, Switzerland ...
Muhammad Umair, Brekhna Hassan, Refath Farzana, Qasim Ali et al.
Background: The emergence of colistin-resistant Enterobacterales (ColRE) is a global public health concern, yet colistin is still widely used in food animals as treatment, metaphylaxis, prophylaxis, and growth promotion. Herein, we investigated the impact of ColRE in Pakistan, global trade of colist...
Naeem Ahammed Ibrahim Fahim, Afsan Sarwer, Zannatul Firdous, Md. Liton Rana et al.
Objectives This study aimed to identify multilocus sequence type (MLST), serotype, average nucleotide identity (ANI), antimicrobial resistance genes (ARGs), virulence genes (VGs), and mobile genetic elements (MGEs) from whole-genome sequences of 10 Escherichia coli isolated from seafood in Banglades...
J Rzaska, A. R. Cooke, Refath Farzana, Brekhna Hassan et al.
Abstract Background The hospital environment can be a hotspot for the emergence of antimicrobial resistance (AMR), with high antibiotic usage and varied cleaning practices acting as a reservoir for AMR bacteria that can persist on surfaces such as bedside tables, door handles or medical equipment. I...
A. R. Cooke, J Rzaska, Refath Farzana, Brekhna Hassan et al.
Abstract Background Antimicrobial resistance (AMR) is one of the fastest growing threats to global human health. Neonates are particularly vulnerable to AMR infections and this problem is exacerbated in LMICs where access to healthcare services and resources including antibiotics are limited. Carbap...
Refath Farzana, Stephan Jürgen Harbarth, Ly‐Mee Yu, Edoardo Carretto et al.
Refath Farzana, T. Mozumder, Badrul Hasan
Background: Multidrug-resistant (MDR) A. baumannii has been a serious challenge in the hospitals globally including Bangladesh. The study was performed to investigate molecular epidemiology & spread dynamics of antibiotic resistant A. baumannii both from patients and hospital environment in Banglade...
Refath Farzana, SM Shamsuzzaman, Kazi Zulfiquer Mamun
Introduction: New Delhi metallo-beta-lactamse-1 (NDM-1) producing superbugs create a global public health problem because of their resistance to most antibiotics. This study was conducted to determine the presence of MBL producers, including NDM-1 producers, in Bangladesh, along with the antimicrobi...