Jason B Harris, Regina C LaRocque, Firdausi Qadri, Edward T Ryan et al.
Cholera is an aute, seretory diarrhoea aused by infetion with Vibrio holerae of the O1 or O139 serogroup. It is endemi in more than 50 ountries and also auses large epidemis. Sine 1817, seven holera pandemis have spread from Asia to muh of the world. The seventh pandemi began in 1961 a...
Jason B. Harris, Regina C. LaRocque, Fahima Chowdhury, Ashraful Islam Khan et al.
BACKGROUND: Despite recent progress in understanding the molecular basis of Vibrio cholerae pathogenesis, there is relatively little knowledge of the factors that determine the variability in human susceptibility to V. cholerae infection. METHODS AND FINDINGS: We performed an observational study of ...
Brian Schwartz, Jason B. Harris, Ashraful Islam Khan, Regina C. LaRocque et al.
We examined demographic, microbiologic, and clinical data from patients presenting during 1988, 1998, and 2004 flood-associated diarrheal epidemics at a diarrhea treatment hospital in Dhaka, Bangladesh. Compared with non-flood periods, individuals presenting during flood-associated epidemics were ol...
Jason B. Harris, Ashraful Islam Khan, Regina C. LaRocque, David J. Dorer et al.
Individuals with blood group O are more susceptible than other individuals to severe cholera, although the mechanism underlying this association is unknown. To assess the respective roles of both intrinsic host factors and adaptive immune responses that might influence susceptibility to infection wi...
Lawrence A. David, Ana A. Weil, Edward T. Ryan, Stephen B. Calderwood et al.
UNLABELLED: Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities ...
Ana A. Weil, Ashraful Islam Khan, Fahima Chowdhury, Regina C. LaRocque et al.
BACKGROUND: Multiple Vibrio cholerae infections in the same household are common. The objective of this study was to examine the incidence of V. cholerae infection and associated clinical symptoms in household contacts of patients with cholera and to identify risk factors for development of severe d...
Paul Farmer, Charles Patrick Almazor, Emily T. Bahnsen, Donna Barry et al.
Meeting Cholera's Challenge to Haiti and the World: A Joint Statement on Cholera Prevention and Care
Regina C. LaRocque, Robert F. Breiman, Mary D. Ari, Roger E. Morey et al.
We collected acute-phase serum samples from febrile patients at 2 major hospitals in Dhaka, Bangladesh, during an outbreak of dengue fever in 2001. A total of 18% of dengue-negative patients tested positive for leptospirosis. The case-fatality rate among leptospirosis patients (5%) was higher than a...
Aaron M. Harris, Md Saruar Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan et al.
Cholera, caused by Vibrio cholerae, is a noninvasive dehydrating enteric disease with a high mortality rate if untreated. Infection with V. cholerae elicits long-term protection against subsequent disease in countries where the disease is endemic. Although the mechanism of this protective immunity i...
Eric J. Nelson, Ashrafuzzaman Chowdhury, James Flynn, Stefan Schild et al.
Cholera outbreaks are proposed to propagate in explosive cycles powered by hyperinfectious Vibrio cholerae and quenched by lytic vibriophage. However, studies to elucidate how these factors affect transmission are lacking because the field experiments are almost intractable. One reason for this is t...
Regina C. LaRocque, Jason B. Harris, Michelle Dziejman, Xiaoman Li et al.
ABSTRACT Understanding gene expression by bacteria during the actual course of human infection may provide important insights into microbial pathogenesis. In this study, we evaluated the transcriptional profile of Vibrio cholerae , the causative agent of cholera, in clinical specimens from cholera p...
Hong Bin Kim, Minghua Wang, Sabeena Ahmed, Chi Hye Park et al.
Ciprofloxacin was introduced for treatment of patients with cholera in Bangladesh because of resistance to other agents, but its utility has been compromised by the decreasing ciprofloxacin susceptibility of Vibrio cholerae over time. We correlated levels of susceptibility and temporal patterns with...
Debasish Saha, Regina C. LaRocque, Ashraful Islam Khan, Jason B. Harris et al.
The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence of Vibrio cholerae O139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic set...
Ashfaqul Alam, Regina C. LaRocque, Jason B. Harris, Cecily Vanderspurt et al.
It has previously been shown that passage of Vibrio cholerae through the human intestine imparts a transient hyperinfectious phenotype that may contribute to the epidemic spread of cholera. The mechanism underlying this human-passaged hyperinfectivity is incompletely understood, in part due to inher...
Firas S. Midani, Ana A. Weil, Fahima Chowdhury, Yasmin Ara Begum et al.
Background: Cholera is a public health problem worldwide, and the risk factors for infection are only partially understood. Methods: We prospectively studied household contacts of patients with cholera to compare those who were infected to those who were not. We constructed predictive machine learni...