Rekha Khandia, Shailja Singhal, Taha Alqahtani, Mohammad Amjad Kamal et al.
Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and mutating continuously, giving rise to various variants with variable degrees of infectivity and lethality. The virus that initially appeared in China later mutated several times, wreaking havoc and claiming many li...
Raj Kumar Singh, Kuldeep Dhama, Sandip Chakraborty, Ruchi Tiwari et al.
Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservo...
Utsang Kumar, Rekha Khandia, Shailja Singhal, Nidhi Puranik et al.
Uneven codon usage within genes as well as among genomes is a usual phenomenon across organisms. It plays a significant role in the translational efficiency and evolution of a particular gene. EPB41L3 is a tumor suppressor protein-coding gene, and in the present study, the pattern of codon usage was...
Rekha Khandia, Mοhd Saeed, Ahmed Alharbi, Ghulam Md Ashraf et al.
Codon usage analysis is a crucial part of molecular characterization and is used to determine the factors affecting the evolution of a gene. The length of a gene is an important parameter that affects the characteristics of the gene, such as codon usage, compositional parameters, and sometimes, its ...
Rekha Khandia, Pankaj Gurjar, Mohammad Amjad Kamal, Nigel H. Greig
Depression negatively impacts mood, behavior, and mental and physical health. It is the third leading cause of suicides worldwide and leads to decreased quality of life. We examined 18 genes available at the genetic testing registry (GTR) from the National Center for Biotechnological Information to ...
Taha Alqahtani, Rekha Khandia, Nidhi Puranik, Ali Alqahtani et al.
Dementia is a clinical syndrome characterized by progressive cognitive decline, and the symptoms could be gradual, persistent, and progressive. In the present study, we investigated 47 genes that have been linked to dementia. Compositional, selectional, and mutational forces were seen to be involved...
Rekha Khandia, Anushri Sharma, Taha Alqahtani, Ali Alqahtani et al.
Neurodegenerative disorders cause irreversible damage to the neurons and adversely affect the quality of life. Protein misfolding and their aggregation in specific parts of the brain, mitochondrial dysfunction, calcium load, proteolytic stress, and oxidative stress are among the causes of neurodegen...
Shailja Singhal, Utsang Kumar, Taha Alqahtani, Igor Rzhepakovsky et al.
INTRODUCTION: Apoptosis and autophagy are the two fundamental processes involved in maintaining homeostasis, and a common stimulus may initiate the processes. Autophagy has been implicated in various diseases, including viral infections. Genetic manipulations leading to altered gene expression might...