Elizabeth A. Ashley, Mehul Dhorda, Rick M. Fairhurst, Chanaki Amaratunga et al.
BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and Apri...
Robert J. Johnston, Kevin Boyle, Wiktor Adamowicz, Jeff Bennett et al.
This article proposes contemporary best-practice recommendations for stated preference (SP) studies used to inform decision making, grounded in the accumulate body of peer-reviewed literature. These recommendations consider the use of SP methods to estimate both use and non-use (passive-use) values,...
Monika Böhm, Ben Collen, Jonathan Baillie, Philip Bowles et al.
Effective and targeted conservation action requires detailed information about species, their distribution, systematics and ecology as well as the distribution of threat processes which affect them. Knowledge of reptilian diversity remains surprisingly disparate, and innovative means of gaining rapi...
Heléne Norder, Anne‐Marie Couroucé, Pierre Coursaget, José Manuel Echevarría et al.
Sequences of 234 complete genomes and 631 hepatitis B surface antigen genes were used to assess the worldwide diversity of hepatitis B virus (HBV). Apart from the described two subgenotypes each for A and F, also B, C, and D divided into four subgenotypes each in the analysis of complete genomes sup...
Honor Bixby, James Bentham, Bin Zhou, Mariachiara Di Cesare et al.
Abstract Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2...
Jennifer Luedtke, Janice Chanson, Kelsey Neam, Louise Hobin et al.
Abstract Systematic assessments of species extinction risk at regular intervals are necessary for informing conservation action 1,2 . Ongoing developments in taxonomy, threatening processes and research further underscore the need for reassessment 3,4 . Here we report the findings of the second Glob...
Stella G. Muthuri, Sudhir Venkatesan, Puja Myles, Jo Leonardi‐Bee et al.
Background Neuraminidase inhibitors were widely used during the 2009–10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and...
Olivo Miotto, Roberto Amato, Elizabeth A. Ashley, Bronwyn MacInnis et al.
We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, ...
Vincent Hsu, M. Jahangir Hossain, Umesh D. Parashar, Mohammed Monsur Ali et al.
We retrospectively investigated two outbreaks of encephalitis in Meherpur and Naogaon, Bangladesh, which occurred in 2001 and We collected serum samples from persons who were ill, their household contacts, randomly selected residents, hospital workers, and various animals. Cases were classified as l...
Shams El Arifeen, Robert E. Black, Gretchen Antelman, Abdullah H Baqui et al.
OBJECTIVES: To describe breastfeeding practices and investigate the influence of exclusive breastfeeding in early infancy on the risk of infant deaths, especially those attributable to respiratory infections (ARI) and diarrhea. METHODS: A prospective observational study was conducted on a birth coho...
Emily S. Gurley, Joel M. Montgomery, M. Jahangir Hossain, Michael Bell et al.
An encephalitis outbreak was investigated in Faridpur District, Bangladesh, in April-May 2004 to determine the cause of the outbreak and risk factors for disease. Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription-PCR ...
David F. Choy, Kevin M. Hart, Lee A. Borthwick, Aarti Shikotra et al.
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), endobronchial tissue gene expression analysis revealed three major patient clusters: TH2-high, TH17-high, and TH2/17...
Marion Campbell, Claire Snowdon, David Francis, Diana Elbourne et al.
OBJECTIVES: To identify factors associated with good and poor recruitment to multicentre trials. DATA SOURCES: Part A: database of trials started in or after 1994 and were due to end before 2003 held by the Medical Research Council and Health Technology Assessment Programmes. Part B: interviews with...
Neal I. Lindeman, Philip T. Cagle, Mary Beth Beasley, Dhananjay Chitale et al.
OBJECTIVE: To establish evidence-based recommendations for the molecular analysis of lung cancers that are required to guide EGFR- and ALK-directed therapies, addressing which patients and samples should be tested, and when and how testing should be performed. PARTICIPANTS: Three cochairs without co...
David M. Reimers, Stephan Thernstrom
Groups and Definitions Acadians Marietta M. LeBreton Afghans David C. Champagne Africans Afro-Americans Thomas C. Holt Albanians Aleuts Dorothy M. Jones Alsatians Frederick C. Luebke American Indians Edward H. Spicer Amish John A. Hostetler Anglo-American Anglo-Saxon Appalachians Dwight Billings and...