Khalequz Zaman, Eliza Roy, Shams El Arifeen, Mahbubur Rahman et al.
BACKGROUND: Young infants and pregnant women are at increased risk for serious consequences of influenza infection. Inactivated influenza vaccine is recommended for pregnant women but is not licensed for infants younger than 6 months of age. We assessed the clinical effectiveness of inactivated infl...
Xin Wang, You Li, Katherine L. O’Brien, Shabir A. Madhi et al.
BACKGROUND: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this s...
Elizabeth P. Schlaudecker, Mark C. Steinhoff, Saad B. Omer, Monica McNeal et al.
BACKGROUND: Antenatal immunization of mothers with influenza vaccine increases serum antibodies and reduces the rates of influenza illness in mothers and their infants. We report the effect of antenatal immunization on the levels of specific anti-influenza IgA levels in human breast milk. (ClinicalT...
Mark C. Steinhoff, Saad B. Omer, Eliza Roy, Shams El Arifeen et al.
BACKGROUND: There are limited data about the effect of maternal influenza infection on fetuses and newborns. We performed a secondary analysis of data from the Mother's Gift project, a randomized study designed to test the effectiveness of inactivated influenza and pneumococcal vaccines during pregn...
Mark C. Steinhoff, Saad B. Omer, Eliza Roy, Shams El Arifeen et al.
The authors present antibody data for mothers and infants from a trial of influenza vaccine in pregnant women. The observations suggest that maternal immunization results in the presence of antibod...
Ahmed Mushfiq Mobarak, Edward Miguel, Jason Abaluck, Amrita Ahuja et al.
Vaccines are changing the course of the COVID-19 pandemic, but in grossly uneven ways. Low- and middle-income countries (LMICs) face considerable obstacles in both receiving and distributing doses. To limit virus transmission, its devastating impacts, and opportunities for further mutations, this mu...
Daisy Higginson, Evropi Τheodoratou, Harish Nair, Tanvir Huda et al.
BACKGROUND: Measles was responsible for an estimated 100,000 deaths worldwide in 2008. Despite being a vaccine-preventable disease, measles remains a major cause of morbidity and mortality in young children. Although a safe and effective injectable measles vaccine has been available for over 50 year...
Emily Henkle, Mark C. Steinhoff, Saad B. Omer, Eliza Roy et al.
BACKGROUND: Exclusive breast-feeding reduces the risk of respiratory illness in infants younger than 6 months of age in developing countries by approximately half. We evaluated the effect of exclusive breast-feeding on respiratory illness with fever (RIF) in Bangladeshi infants in the context of a r...
Ahmad J. Obaidullah, Mohammed M. Alanazi, Nawaf A. Alsaif, Wael A. Mahdi et al.
This study assessed the anxiolytic and antidepressant activities of a methanol leaves extract of Cnesmone javanica (CV) in Swiss albino mice. The study found a significant increase in the percentage of time spent in the open arms of an elevated plus maze and in the incidence of head dipping in hole-...
Emily Henkle, Mark C. Steinhoff, Saad B. Omer, Eliza Roy et al.
We evaluated infant sera from an immunization trial in Bangladesh to assess influenza hemagglutination inhibition antibody titer increases in 131 unimmunized infants from birth to 6 months. We detected 31 serologically defined infections. Combined with 10 additional rapid test-proven influenza cases...
Saad B. Omer, Khalequ Zaman, Eliza Roy, Shams El Arifeen et al.
A 2 × 2 factorial trial was performed to determine the efficacy of antennal influenza vaccination of mothers plus pneumococcal conjugate vaccination of their infants against respiratory illness during early infancy. The efficacy of trivalent inactivated influenza vaccine (TIV; delivered to mothers) ...
Joseph J. Campo, Antti Seppo, Arlo Randall, Jozelyn Pablo et al.
BACKGROUNDThe use of high-throughput technologies has enabled rapid advancement in the knowledge of host immune responses to pathogens. Our objective was to compare the repertoire, protection, and maternal factors associated with human milk antibodies to infectious pathogens in different economic an...
Elizabeth P. Schlaudecker, Mark C. Steinhoff, Saad B. Omer, Eliza Roy et al.
Background Pneumococcal infections are a significant cause of morbidity and mortality, and young infants are particularly vulnerable to infection. Maternal immunization can protect infants, but there are limited data on the duration of pneumococcal vaccine antibody in pregnant women. We report on ma...
Božidarka Knežević, Zorana Vasiljević, Ljilja Musić, L. Krivokapic et al.
It is essential that context-appropriate health research and health interventions take place in countries with economy in transition. The aims of this study were to describe the clinical characteristics, management, and in-hospital outcomes of acute coronary syndrome (ACS) patients with heart failur...
Rosauro Varo, Kaitlin Cole, Zachary J. Madewell, Jaime Fanjul Iglesias et al.
OBJECTIVES: To describe (1) the proportion of deaths that were in recently hospitalised children and (2) causes of mortality among deceased children aged 0-59 months with preceding hospitalisations who enrolled in a mortality surveillance programme. DESIGN: Descriptive study using prospectively coll...