Abdullah H Baqui, Shams El Arifeen, Gary L. Darmstadt, Saifuddin Ahmed et al.
BACKGROUND Neonatal mortality accounts for a high proportion of deaths in children under the age of 5 years in Bangladesh. Therefore the project for advancing the health of newborns and mothers (Projahnmo) implemented a community-based intervention package through government and non-government organ...
Neal Russell, Anna C. Seale, Megan O’Driscoll, Catherine O’Sullivan et al.
BACKGROUND: Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide. METHODS: We conducted systematic literature reviews (PubMed/Medline,...
Anna C. Seale, Fiorella Bianchi-Jassir, Neal Russell, Maya Kohli-Lynch et al.
BACKGROUND: We aimed to provide the first comprehensive estimates of the burden of group B Streptococcus (GBS), including invasive disease in pregnant and postpartum women, fetal infection/stillbirth, and infants. Intrapartum antibiotic prophylaxis is the current mainstay of prevention, reducing ear...
Xin Wang, You Li, Katherine L. O’Brien, Shabir A. Madhi et al.
BACKGROUND: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this s...
Lola Madrid, Anna C. Seale, Maya Kohli-Lynch, Karen Edmond et al.
BACKGROUND: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasiv...
Anne CC Lee, Luke C. Mullany, Alain K. Koffi, Iftekhar Rafiqullah et al.
Abstract Background Urinary tract infection (UTI) in pregnancy, including asymptomatic bacteriuria, is associated with maternal morbidity and adverse pregnancy outcomes, including preterm birth and low birthweight. In low-middle income countries (LMICs), the capacity for screening and treatment of U...
Ray Borrow, Pedro Alarcón, Josefina Carlos, Dominique A. Caugant et al.
INTRODUCTION: The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisser...
Fiorella Bianchi-Jassir, Anna C. Seale, Maya Kohli-Lynch, Joy E Lawn et al.
BACKGROUND: Preterm birth complications are the leading cause of deaths among children <5 years of age. Studies have suggested that group B Streptococcus (GBS) maternal rectovaginal colonization during pregnancy may be a risk factor for preterm delivery. This article is the fifth of 11 in a series. ...
Samir K. Saha, Stephanie J. Schrag, Shams El Arifeen, Luke C. Mullany et al.
BACKGROUND: More than 500 000 neonatal deaths per year result from possible serious bacterial infections (pSBIs), but the causes are largely unknown. We investigated the incidence of community-acquired infections caused by specific organisms among neonates in south Asia. METHODS: From 2011 to 2014, ...
Andrew J. Stewardson, Kalisvar Marimuthu, Sharmila Sengupta, Arthur Allignol et al.
BACKGROUND Low-income and middle-income countries (LMICs) are under-represented in reports on the burden of antimicrobial resistance. We aimed to quantify the clinical effect of carbapenem resistance on mortality and length of hospital stay among inpatients in LMICs with a bloodstream infection due ...
Elizabeth Fitchett, Anna C. Seale, Stefania Vergnano, Michael Sharland et al.
Neonatal infections are estimated to account for a quarter of the 2·8 million annual neonatal deaths, as well as approximately 3% of all disability-adjusted life-years. Despite this burden, few data are available on incidence, aetiology, and outcomes, particularly regarding impairment. We aimed to d...
Maya Kohli-Lynch, Neal Russell, Anna C. Seale, Ziyaad Dangor et al.
BACKGROUND: Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopmental impairment (NDI), a burden not previously systematically quantified. This is the 10th of 11 articles estimating the burden of GBS disease. Here we aimed to estimate NDI in survivors of infant GBS di...
Kirsty Le Doaré, Megan O’Driscoll, Kim Turner, Farah Seedat et al.
BACKGROUND: Intrapartum antibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease. However, there is no description of how IAP is used around the world. This article is the sixth in a series estimating the burden of GBS disease. Here we aimed to review GBS scree...
Gary L. Darmstadt, Samir K. Saha, ASM Nawshad Uddin Ahmed, MAK Azad Chowdhury et al.
Background Infections and complications of prematurity are main causes of neonatal mortality. Very low birthweight premature infants have compromised skin barrier function, and are at especially high risk for serious infections and mortality. Our aim was to ascertain whether topical application of e...
Neal Russell, Anna C. Seale, Catherine O’Sullivan, Kirsty Le Doaré et al.
BACKGROUND: Early-onset group B streptococcal disease (EOGBS) occurs in neonates (days 0-6) born to pregnant women who are rectovaginally colonized with group B Streptococcus (GBS), but the risk of EOGBS from vertical transmission has not been systematically reviewed. This article, the seventh in a ...