Megan E. Carey, Zoe A. Dyson, Danielle J. Ingle, Afreenish Amir et al.
Background: serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000). Methods: This is a meta-analysis of global genotype and anti...
James Meiring, Farhana Khanam, Buddha Basnyat, Richelle C. Charles et al.
Typhoid fever is an invasive bacterial disease associated with bloodstream infection that causes a high burden of disease in Africa and Asia. Typhoid primarily affects individuals ranging from infants through to young adults. The causative organism, Salmonella enterica subsp. enterica serovar Typhi ...
Sikander M. Mirza, Samuel Kariuki, Kazi Zulfiquer Mamun, Nicholas J. Beeching et al.
Molecular analysis of chromosomal DNA from 193 multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolates from 1990 to 1995 from Pakistan, Kuwait, Malaysia, Bangladesh, and India produced a total of five major different pulsed-field gel electrophoresis (PFGE) patterns. Even within a partic...
Samuel Kariuki, Cecilia Mbae, Sandra Van Puyvelde, Robert Onsaŕe et al.
Invasive Non-typhoidal Salmonella (iNTS) disease is a major public health challenge, especially in Sub-Saharan Africa (SSA). In Kenya, mortality rates are high (20-25%) unless prompt treatment is instituted. The most common serotypes are Salmonella enterica serotype Typhimurium (S. Typhimurium) and ...
Samuel Kariuki, Zoe A. Dyson, Cecilia Mbae, Ronald Ngetich et al.
Background: Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control. Methods: In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls...
Cecilia Mbae, Moses Mwangi, Naomi Gitau, Tabitha Irungu et al.
Abstract Background In Kenya, typhoid fever and invasive non-typhoidal salmonellosis present a huge burden of disease, especially in poor-resource settings where clean water supply and sanitation conditions are inadequate. The epidemiology of both diseases is poorly understood in terms of severity a...
Sujit Bhattacharya, Robert E. Black, Lawrence L. Bourgeois, John D. Clemens et al.
Long-lasting cholera outbreaks in Africa suggest limitations in the current strategy of disease control.
Samuel Kariuki, Cecilia Mbae, Robert Onsaŕe, Susan Kavai et al.
BACKGROUND: Salmonella infections cause a disproportionately high number of deaths in Africa, especially among poor urban populations. The increasing level of multidrug-resistant (MDR) infections is a major cause of concern in these settings where alternative effective treatment is unavailable. Othe...
Kasia Stepniewska, Elizabeth Allen, Georgina Humphreys, Eugenie Poirot et al.
BACKGROUND: In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) without glucose-6-phosphate dehydrogenase (G6PD) testing, to accelerate malaria ...
Hilary P. Browne, Najeeha Talat Iqbal, Majdi Osman, Caroline Tigoi et al.
Studies of the microbes living on and in our bodies are conducted mainly in a few rich countries, squandering opportunities to improve the health of people globally. Studies of the microbes living on and in our bodies are conducted mainly in a few rich countries, squandering opportunities to improve...
Karen H. Keddy, Senjuti Saha, Iruka N. Okeke, John Bosco Kalule et al.
Despite efforts to reduce the global burden of childhood diarrhoea, 50% of all cases globally occur in children under five years in LowIncome and Middle-Income Countries (LMICs) and knowledge gaps remain regarding the aetiological diagnosis, introduction of diarrhoeal vaccines, and the role of envir...
Karen H Keddy, Senjuti Saha, Samuel Kariuki, John Bosco Kalule et al.
Diarrhoea is an important cause of morbidity and mortality in children from low-income and middle-income countries (LMICs), despite advances in the management of this condition. Understanding of the causes of diarrhoea in children in LMICs has advanced owing to large multinational studies and big da...
Samuel Kariuki, Zoe A. Dyson, Cecilia Mbae, Ronald Ngetich et al.
Abstract Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control. In a 3 year case-control study, we investigated typhoid among children aged <16 years (4,670 febrile cases and 8,549 age matched controls) livin...
Fahima Chowdhury, Md Taufiqul Islam, Faisal Ahmmed, Afroza Akter et al.
Background: (ETEC) is a major cause of diarrheal illness, and population-based data on the incidence of clinically significant ETEC diarrhea in developing countries are limited. We provide insight into ETEC epidemiology; we followed a population-based cohort in a vaccine trial. Methods: We analyzed ...
Md Sayem, Mostofa Hasan, Md Jahidul, Islam Joy et al.
Since banks mobilize financial resources across the economy, they are expected to be critical in bringing about financial stability and economic progress. The purpose of this research was to determine the impact of macroeconomic variables on the financial performance of commercial banks in Banglades...
Megan E. Carey, Zoe A. Dyson, Danielle J. Ingle, Afreenish Amir et al.
Abstract The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks twenty-one years since the publication of the fi...
Yan Shao, Shuyi Wang, Bonface M. Gichuki, Mark Stares et al.
Bifidobacterium longum and B. infantis are pioneer colonizers of the neonatal gut and are widely used as probiotics to support infant growth, development, and disease resistance. However, commercial strains derived largely from high-income countries (HICs) may be suboptimal for infants in low- and m...
Nisha Singh, Rahma O. Golicha, Chetan Singh Thakur, Mathew A. Beale et al.
Aeromonads are an ecologically versatile group of bacteria that cause infections in aquatic animals and are recognised as emerging human pathogens. Despite this, our understanding of Aeromonas diversity, especially the relationship between clinical and environmental strains, remains limited. Here, w...
Shao Yan, Shuyi Wang, Bonface M. Gichuki, Mark Stares et al.
Beatrice Ongadi, Asma Binte Aziz, Cecilia Mbae, Moses Mwangi et al.
Abstract Background Shigella spp are among the notable causes of global diarrheal disease and death, accounting for 13.2% of deaths in 2016. Antimicrobial resistance complicates shigellosis management. Understanding local disease epidemiology is crucial for developing effective preventive strategies...