Marieke S. van de Loosdrecht, Abdeljalil Bouzouggar, Louise Humphrey, Cosimo Posth et al.
North Africa is a key region for understanding human history, but the genetic history of its people is largely unknown. We present genomic data from seven 15,000-year-old modern humans, attributed to the Iberomaurusian culture, from Morocco. We find a genetic affinity with early Holocene Near Easter...
Carol A. Gilchrist, Sarah E. Petri, Brittany N. Schneider, Daniel Reichman et al.
BACKGROUND: An estimated 1 million children die each year before their fifth birthday from diarrhea. Previous population-based surveys of pediatric diarrheal diseases have identified the protozoan parasite Entamoeba histolytica, the etiological agent of amebiasis, as one of the causes of moderate-to...
Poonum Korpe, Rashidul Haque, Carol A. Gilchrist, Cristian Valencia et al.
BACKGROUND: Cryptosporidiosis is a common cause of infectious diarrhea in young children worldwide, and is a significant contributor to under-five mortality. Current treatment options are limited in young children. In this study, we describe the natural history of Cryptosporidium spp. infection in a...
Wanze Xie, Sarah K. G. Jensen, Mark Wade, Swapna Kumar et al.
BACKGROUND: Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers'...
Elizabeth M. McClure, Ana L. Garcés, Patricia L. Hibberd, Janet Moore et al.
Abstract Background The Global Network for Women's and Children’s Health Research (Global Network) conducts clinical trials in resource-limited countries through partnerships among U.S. investigators, international investigators based in in low and middle-income countries (LMICs) and a central data ...
Ibne Karim M. Ali, Shahram Solaymani-Mohammadi, Jasmine Akhter, Shantanu Roy et al.
Entamoeba histolytica infection may have various clinical manifestations. Nine out of ten E. histolytica infections remain asymptomatic, while the remainder become invasive and cause disease. The most common form of invasive infection is amebic diarrhea and colitis, whereas the most common extra-int...
Alan Tita, Waldemar A. Carlo, Elizabeth M. McClure, Musaku Mwenechanya et al.
BACKGROUND: The use of azithromycin reduces maternal infection in women during unplanned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithromycin would reduce maternal and offspring sepsis or death. METHO...
Sarah K. G. Jensen, Swapna Kumar, Wanze Xie, Fahmida Tofail et al.
In this paper we explore the relationship between the Visual Evoked Potential (VEP), a component of the electroencephalogram elicited by visual stimuli, and cognitive functions in children growing up in an urban slum in Bangladesh. VEPs in response to pattern-reversing checkerboards were collected i...
Katherine L. Perdue, Sarah K. G. Jensen, Swapna Kumar, John E. Richards et al.
Children living in low-resource settings are at risk for failing to reach their developmental potential. While the behavioral outcomes of growing up in such settings are well-known, the neural mechanisms underpinning poor outcomes have not been well elucidated, particularly in the context of low- an...
Sarah K. G. Jensen, Fahmida Tofail, Rashidul Haque, William A. Petri et al.
It is well established that low resource environments early in life can predispose children to adverse health and compromised developmental outcomes. We explore possible mechanistic pathways underlying poor developmental outcomes in children growing up in a low resource setting in urban Bangladesh. ...
Seemab Naqvi, Sarah Saleem, Farnaz Naqvi, Sk Masum Billah et al.
OBJECTIVES: We sought to determine the knowledge, attitudes and practices of pregnant women regarding COVID-19 vaccination in pregnancy in seven low- and middle-income countries (LMIC). DESIGN: Prospective, observational, population-based study. SETTINGS: Study areas in seven LMICs: Bangladesh, Indi...
Hans Verkerke, Shihab U. Sobuz, Z. Jennie, Sarah E. Petri et al.
Rotavirus is a leading cause of dehydrating diarrhea and death among infants and children globally, particularly in communities of the developing world. While numerous studies have described the complex relationships among infectious diarrhea, growth faltering, and poverty, the impact of nutritional...
Sarah K. G. Jensen, Wanze Xie, Swapna Kumar, Rashidul Haque et al.
Studies of infants growing up in high-income countries reveal developmental changes in electroencephalography (EEG) power whereby socioeconomic factors - specifically, low SES and low income - are associated with lower EEG power in infants aged newborn to nine months. In the current paper we explore...
Ashley Bach, Wanze Xie, Laura Piazzoli, Sarah K. G. Jensen et al.
The first years of life are a sensitive period of rapid neural and immune system development vulnerable to the impact of adverse experiences. Several studies support inflammation as a consequence of various adversities and an exposure negatively associated with developmental outcomes. The mechanism ...
Ted K. Turesky, Sarah K. G. Jensen, Xi Yu, Swapna Kumar et al.
Childhood poverty has been associated with structural and functional alterations in the developing brain. However, poverty does not alter brain development directly, but acts through associated biological or psychosocial risk factors (e.g. malnutrition, family conflict). Yet few studies have investi...