Shafiqul Alam Sarker, Shamima Sultana, Gloria Reuteler, D Moine et al.
BACKGROUND: Antibiotic resistance is rising in important bacterial pathogens. Phage therapy (PT), the use of bacterial viruses infecting the pathogen in a species-specific way, is a potential alternative. METHOD: T4-like coliphages or a commercial Russian coliphage product or placebo was orally give...
Shamima Akter, Md Mizanur Rahman, Sarah Krull Abe, Papia Sultana
OBJECTIVE: To estimate the prevalence of diabetes and prediabetes in Bangladesh using national survey data and to identify risk factors. METHODS: Sociodemographic and anthropometric data and data on blood pressure and blood glucose levels were obtained for 7541 adults aged 35 years or more from the ...
Shawna McCallin, Shafiqul Alam Sarker, Caroline Barretto, Shamima Sultana et al.
Phage therapy has a long tradition in Eastern Europe, where preparations are comprised of complex phage cocktails whose compositions have not been described. We investigated the composition of a phage cocktail from the Russian pharmaceutical company Microgen targeting Escherichia coli/Proteus infect...
Shafiqul Alam Sarker, Shawna McCallin, Caroline Barretto, Bernard Berger et al.
The genomic diversity of 99 T4-like coliphages was investigated by sequencing an equimolar mixture with Illumina technology and screening them against different databases for horizontal gene transfer and undesired genes. A 9-phage cocktail was given to 15 healthy adults from Bangladesh at a dose of ...
Shafiqul Alam Sarker, Shamima Sultana, George J. Fuchs, Nur Alam et al.
BACKGROUND: Previous studies have shown that selected strains of lactobacilli that are administered orally result in a modest reduction of diarrhea duration. However, duration alone is not considered optimal for therapeutic evaluation of any agent in diarrhea. OBJECTIVE: To examine the effect of a n...
Shafiqul Alam Sarker, Bernard Berger, Ying Deng, Silas Kieser et al.
A T4-like coliphage cocktail was given with different oral doses to healthy Bangladeshi children in a placebo-controlled randomized phase I safety trial. Fecal phage detection was oral dose dependent suggesting passive gut transit of coliphages through the gut. No adverse effects of phage applicatio...
Shawna McCallin, Shafiqul Alam Sarker, Shamima Sultana, Frank Oechslin et al.
Bacteriophage therapy is a commonly used treatment for Staphylococcus aureus infections in countries of the former Soviet Union, using both single phages and phage cocktails. The scarce data available on Eastern phage cocktails prompted an investigation into commercially-available Pyophage cocktails...
Tommi Vatanen, Qi Yan Ang, Léa Siegwald, Shafiqul Alam Sarker et al.
The gut microbiome has an important role in infant health and development. We characterized the fecal microbiome and metabolome of 222 young children in Dhaka, Bangladesh during the first two years of life. A distinct Bifidobacterium longum clade expanded with introduction of solid foods and harbore...
Md. Badiuzzaman Khan, Sabina Yeasmin Urmy, Shamsunnahar Setu, Abeer Hossain Kanta et al.
Microplastics (MPs) are a growing concern due to its ubiquitous presence and exceptional stability. We examined the abundance, dispersion, and attributes of MPs in the sediment and fish species of the Turag River in Bangladesh, which separated the industrial city Gazipur from the Mega-city Dhaka. Co...
Shafi Mahmud, Suvro Biswas, Gobindo Kumar Paul, Mohasana Akter Mita et al.
The recent coronavirus outbreak has changed the world's economy and health sectors due to the high mortality and transmission rates. Because the development of new effective vaccines or treatments against the virus can take time, an urgent need exists for the rapid development and design of new drug...
Gilles Bourdin, Armando Navarro, Shafiqul Alam Sarker, A.C. Pittet et al.
Eighty-nine T4-like phages from our phage collection were tested against four collections of childhood diarrhoea-associated Escherichia coli isolates representing different geographical origins (Mexico versus Bangladesh), serotypes (69 O, 27 H serotypes), pathotypes (ETEC, EPEC, EIEC, EAEC, VTEC, Sh...
Sadia Afrin, Hasibur Rahman Shuvo, Banjir Sultana, Faridul Islam et al.
The effluents from textile industries without proper treatment contains a remarkable amount of synthetic dyes which are harmful to the environment and a big challenge globally to degrade it with a eco-friendly way. Conventional methods are extremely energy-consuming, non-effective and generate a tox...
Abu Montakim Tareq, Saifuddin Farhad, A Uddin, Muminul Hoque et al.
value of 631.44 μg/mL. MECP (62.5-500 μg/mL) elicited 20.96-38.12% decreased protein denaturation compared to diclofenac sodium (65.40-83.50%), while a 35.72% (P < 0.001) clot lysis activity was observed for the 10 mg/mL concentration. MECP induced a dose-dependent reduction in locomotor activity, w...
Shafiqul Alam Sarker, Martin Jäkel, Shamima Sultana, Nur Alam et al.
Background & aims Rotavirus infection is a leading cause of morbidity and mortality in children younger than 5 years of age. Current treatment options are limited. We assessed the efficacy of a llama-derived, heavy-chain antibody fragment called anti-rotavirus protein (ARP1), in modifying the severi...
Abu Naser Md Ahsanul Haque, Nigar Sultana, Abu Sadat Muhammad Sayem, Shamima Akter Smriti
The extensive use of dyes in numerous industries results in massive dye discharge in the wastewater, which is a major cause of water pollution. Globally, the consumption of dyes is near seven hundred thousand tons across different sectors, of which around 10–15% goes into the wastewater. Among the d...