Christine Marie George, Lauren Oldja, Shwapon Biswas, Jamie Perin et al.
There is a growing body of literature indicating an association between stunting and environmental enteropathy (EE), a disorder thought to be caused by repeated exposures to enteric pathogens. To investigate the relationship between exposure to enteric pathogens through geophagy, consumption of soil...
Firdausi Qadri, Mohammad Ali, Fahima Chowdhury, Ashraful Islam Khan et al.
Background Cholera is endemic in Bangladesh with epidemics occurring each year. The decision to use a cheap oral killed whole-cell cholera vaccine to control the disease depends on the feasibility and effectiveness of vaccination when delivered in a public health setting. We therefore assessed the f...
Christine Marie George, Shirajum Monira, David A. Sack, Mahamud‐ur Rashid et al.
The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Interven...
Christine Marie George, Lauren Oldja, Shwapon Biswas, Jamie Perin et al.
Undernutrition is estimated to be an underlying cause of over half of all deaths in young children globally. There is a growing body of literature suggesting that increased exposure to enteric pathogens is responsible for environmental enteropathy (EE), a disorder associated with impaired growth in ...
Christine Marie George, Vanessa Burrowes, Jamie Perin, Lauren Oldja et al.
OBJECTIVE: To investigate the relationship between faecal contamination in child play spaces, enteric infections, environmental enteropathy (EE) and impaired growth among young children. METHODS: A prospective cohort study was conducted of 203 children 6-30 months of age in rural Bangladesh. Stool s...
Christine Marie George, Shwapon Biswas, Danielle Jung, Jamie Perin et al.
Inadequate hand hygiene is estimated to result in nearly 300,000 deaths annually, with the majority of deaths being among children younger than 5 years. In an effort to promote handwashing with soap and water treatment behaviors among highly susceptible household members of cholera patients, we rece...
Christine Marie George, Lauren Oldja, Shwapon Biswas, Jamie Perin et al.
Objective To investigate the relationship between unsafe child feces disposal, environmental enteropathy, and impaired growth, we conducted a prospective cohort study of 216 young children in rural Bangladesh. Study design Using a prospective cohort study design in rural Bangladesh, unsafe child fec...
Tomohiko Morita, Jamie Perin, Lauren Oldja, Shwapon Biswas et al.
OBJECTIVE: To characterise childhood mouthing behaviours and to investigate the association between object-to-mouth and food-to-mouth contacts, diarrhoea prevalence and environmental enteropathy. METHODS: A prospective cohort study was conducted of 216 children ≤30 months of age in rural Bangladesh....
Christine Marie George, Danielle Jung, KM Saif‐Ur‐Rahman, Shirajum Monira et al.
Diarrhea is the second leading cause of death in children under 5 years of age globally. The time patients and caregivers spend at a health facility for severe diarrhea presents the opportunity to deliver water, sanitation, and hygiene (WASH) interventions. We recently developed Cholera-Hospital-Bas...
Nusrat Najnin, Karin Leder, Firdausi Qadri, Andrew Forbes et al.
Background: Information on the impact of hygiene interventions on severe outcomes is limited. As a pre-specified secondary outcome of a cluster-randomized controlled trial among >400 000 low-income residents in Dhaka, Bangladesh, we examined the impact of cholera vaccination plus a behaviour change ...
Vanessa Burrowes, Jamie Perin, Shirajum Monira, David A. Sack et al.
Household contacts of cholera patients are at a 100 times higher risk of a Vibrio cholerae infection than the general population. To examine risk factors for V. cholerae infections and investigate intervention strategies among this population, we followed household contacts of cholera patients for t...
Jamie Perin, Alvin G. Thomas, Lauren Oldja, Shahnawaz Ahmed et al.
Objective To determine the relationship between geophagy (mouthing of dirt, sand, clay, or mud) and growth faltering in young children. Study design We examined linear growth as height and weight standardized by age and sex, and weight standardized by height, in a cohort of children aged 6-36 months...
Mahamud‐ur Rashid, Christine Marie George, Shirajum Monira, Toslim Mahmud et al.
Abstract Household members of cholera patients are at a 100 times higher risk of cholera infections than the general population because of shared contaminated drinking water sources and secondary transmission through poor household hygiene practices. In this study, we investigated the bactericidal c...
Jamie Perin, Vanessa Burrowes, Mathieu Almeida, Shahnawaz Ahmed et al.
The microbial communities residing in the child gut are thought to play an important role in child growth, although the relationship is not well understood. We examined a cohort of young children from Mirzapur, Bangladesh, prospectively over 18 months. Four fecal markers of environmental enteropathy...
Nusrat Najnin, Karin Leder, Andrew Forbes, Leanne Unicomb et al.
We assessed the impact of handwashing promotion on reported respiratory illness as a secondary outcome from among > 60,000 low-income households enrolled in a cluster-randomized trial conducted in Bangladesh. Ninety geographic clusters were randomly allocated into three groups: cholera-vaccine-on...