W Cairns S Smith, Alison Anderson, Stephen G Withington, Wim H. van Brakel et al.
OBJECTIVE: To determine whether addition of low dose prednisolone to multidru treatment can prevent reaction and nerve function impairment in leprosy. DESIN: Multicentre, double blind, randomised, placebo controlled, parallel roup trial. SETTIN: Six centres in Banladesh and Nepal. PARTICIPANTS:...
Jan Hendrik Richardus, Stephen G Withington, Alison Anderson, RICHARD P. CROFT et al.
Some leprosy patients with long-standing nerve function impairment (NFI) appear to have responded favourably to treatment with corticosteroids. This study investigated whether patients with untreated NFI between 6 and 24 months duration and who are given standard regimen corticosteroid therapy, will...
Wim H. van Brakel, Alison Anderson, Stephen G Withington, RICHARD P. CROFT et al.
This study was designed to investigate whether leprosy patients diagnosed with mild sensory impairment have a better prognosis when treated with steroids than similarly impaired patients treated with placebo. A multi-centre, randomized, double-blind, placebo-controlled trial was conducted in Nepal a...
Jan Hendrik Richardus, Stephen G Withington, Alison Anderson, RICHARD P. CROFT et al.
Reactions in leprosy causing nerve function impairment (NFI) are increasingly treated with standardized regimens of corticosteroids, often under field conditions. Safety concerns led to an assessment of adverse events of corticosteroids, based on data of three trials studying prevention of NFI (the ...
C. Ruth Butlin, David Pahan, Aung Kya Jai Maug, Stephen G Withington et al.
Introduction: Duration of leprosy treatment remains long and difficult to complete in resource poor areas. Studies suggest that shortening duration of therapy for MB patients to 6 months may be possible. Methods: New MB patients in 2005 in two NGO projects in Bangladesh were treated with 6 months WH...
C. Ruth Butlin, K. J. M. Aung, Stephen G Withington, Peter Nicholls et al.
Introduction: Since 1998 the recommended duration of treatment for multi- bacillary (MB) leprosy cases has been 12 months. Further shortening the duration of multi-drug therapy (MDT) for MB cases has been proposed, but evidence regarding long term outcomes is still needed. Disability outcomes are as...
Stephen G Withington, A. N. Maksuda, Mohammad Salim, Jalal Ahmed
Elimination of leprosy as a public health problem, defined by a registered prevalence of less than one case per 10,000 population, was achieved by Bangladesh in 1998, and steady reduction in prevalence is ongoing. It is less certain whether a sustained reduction in case detection is occurring, with ...